| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 1956 |
Name | EGFR |
Synonym | ERBB|ERBB1|HER1|PIG61|mENA;epidermal growth factor receptor;EGFR;epidermal growth factor receptor |
Definition | avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|cell growth inhibiting protein 40|cell proliferation-inducing protein 61|proto-oncogene c-ErbB-1|receptor tyrosine-protein kinase erbB-1 |
Position | 7p12 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | PDGFR-beta- and EGFR-immunoreactivity of pulmonary vessels distinguishes pulmonary arterial hypertension patients from controls. |
PAH | "Regression of experimental pulmonary hypertension was also achieved by blocking a downstream effector of elastase, the EGF receptor." |
PH | Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension. |
| More detail of all Human literatures about EGFR | |
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Pathways and Diseases |
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Pathway | agrin in postsynaptic differentiation;PID BioCarta;100252 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | Syndecan-3-mediated signaling events;PID Curated;200170 |
Pathway | sprouty regulation of tyrosine kinase signals;PID BioCarta;100029 |
Pathway | trefoil factors initiate mucosal healing;PID BioCarta;100018 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | EGFR downregulation;PID Reactome;500515 |
Pathway | a6b1 and a6b4 Integrin signaling;PID Curated;200162 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | EGFR-dependent Endothelin signaling events;PID Curated;200095 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | cbl mediated ligand-induced downregulation of egf receptors pathway;PID BioCarta;100216 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Dorso-ventral axis formation;KEGG PATHWAY;hsa04320 |
Pathway | Signaling by EGFR;PID Reactome;500510 |
Pathway | map kinase inactivation of smrt corepressor;PID BioCarta;100032 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Signal transduction by L1;PID Reactome;500100 |
Pathway | ErbB receptor signaling network;PID Curated;200136 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Bladder cancer;KEGG PATHWAY;hsa05219 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Arf6 signaling events;PID Curated;200060 |
Pathway | mcalpain and friends in cell motility;PID BioCarta;100111 |
Pathway | Internalization of ErbB1;PID Curated;200146 |
Pathway | Stabilization and expansion of the E-cadherin adherens junction;PID Curated;200155 |
Pathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy;PID BioCarta;100221 |
Disease | CANCER;GAD |
Disease | Lupus erythematosus;FunDO |
Disease | IMMUNE;GAD |
Disease | Gastric cancer;KEGG DISEASE;H00018 |
Disease | Gastrointestinal tumor;FunDO |
Disease | Cholelithiasis;FunDO |
Disease | Cytomegalovirus infection;FunDO |
Disease | Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in;OMIM |
Disease | Atopic rhinitis;FunDO |
Disease | Asthma;FunDO |
Disease | Cancer;FunDO |
Disease | Oral cancer;FunDO |
Disease | glioblastoma multiforme;GAD |
Disease | Acute Coronary Syndrome;GAD |
Disease | Bladder cancer;KEGG DISEASE;H00022 |
Disease | Esotropia;FunDO |
Disease | Hypercholesterolemia;FunDO |
Disease | Barrett's esophagus;FunDO |
Disease | Pleural effusion, Malignant;FunDO |
Disease | lung cancer;GAD |
Disease | prostatic hyperplasia;GAD |
Disease | anaplastic astrocytoma;GAD |
Disease | pancreatic cancer;GAD |
Disease | brain cancer;GAD |
Disease | prostate cancer;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | Choriocarcinoma;KEGG DISEASE;H00028 |
Disease | Asthma;GAD |
Disease | Exanthema;GAD |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | Cardiomyopathy, Dilated;GAD |
Disease | Stroke;FunDO |
Disease | Yersinia infection;FunDO |
Disease | Glaucoma;FunDO |
Disease | colorectal cancer;GAD |
Disease | Drug abuse;FunDO |
Disease | Adenocarcinoma of lung, response to tyrosine kinase inhibitor in;OMIM |
Disease | radiation sensitivity;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | Thrombophlebitis;FunDO |
Disease | rectal cancer;GAD |
Disease | lupus erythematosus;GAD |
Disease | Lung Neoplasms;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Adenovirus infection;FunDO |
Disease | Schizophrenia;FunDO |
Disease | Testicular dysfunction;FunDO |
Disease | Oral cancer;KEGG DISEASE;H00016 |
Disease | Laryngeal cancer;KEGG DISEASE;H00055 |
Disease | Cancers of the breast and female genital organs;KEGG DISEASE |
Disease | Endometriosis;FunDO |
Disease | Carcinoma, Non-Small-Cell Lung;GAD |
Disease | Cancers of the nervous system;KEGG DISEASE |
Disease | Cancers;KEGG DISEASE |
Disease | Cervical cancer;KEGG DISEASE;H00030 |
Disease | Optic atrophy;FunDO |
Disease | Cancers of the urinary system and male genital organs;KEGG DISEASE |
Disease | head and neck cancer;GAD |
Disease | Primary hyperparathyroidism;FunDO |
Disease | Skin cancer;FunDO |
Disease | Glioma;KEGG DISEASE;H00042 |
Disease | Papillary adenocarcinoma;FunDO |
Disease | polycystic kidney disease;GAD |
Disease | Head and neck cancers;KEGG DISEASE |
Disease | Nonsmall cell lung cancer, susceptibility to;OMIM |
Disease | RENAL;GAD |
Disease | Esophageal cancer;KEGG DISEASE;H00017 |
Disease | Common wart;FunDO |
Disease | Angiomyolipoma;FunDO |
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External Links |
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Links to Entrez Gene | 1956 |
Links to all GeneRIF Items | 1956 |
Links to iHOP | 1956 |
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Sequence Information |
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Nucleotide Sequence |
>1956 : length: 3633 atgcgaccctccgggacggccggggcagcgctcctggcgctgctggctgcgctctgcccg gcgagtcgggctctggaggaaaagaaagtttgccaaggcacgagtaacaagctcacgcag ttgggcacttttgaagatcattttctcagcctccagaggatgttcaataactgtgaggtg gtccttgggaatttggaaattacctatgtgcagaggaattatgatctttccttcttaaag accatccaggaggtggctggttatgtcctcattgccctcaacacagtggagcgaattcct ttggaaaacctgcagatcatcagaggaaatatgtactacgaaaattcctatgccttagca gtcttatctaactatgatgcaaataaaaccggactgaaggagctgcccatgagaaattta caggaaatcctgcatggcgccgtgcggttcagcaacaaccctgccctgtgcaacgtggag agcatccagtggcgggacatagtcagcagtgactttctcagcaacatgtcgatggacttc cagaaccacctgggcagctgccaaaagtgtgatccaagctgtcccaatgggagctgctgg ggtgcaggagaggagaactgccagaaactgaccaaaatcatctgtgcccagcagtgctcc gggcgctgccgtggcaagtcccccagtgactgctgccacaaccagtgtgctgcaggctgc acaggcccccgggagagcgactgcctggtctgccgcaaattccgagacgaagccacgtgc aaggacacctgccccccactcatgctctacaaccccaccacgtaccagatggatgtgaac cccgagggcaaatacagctttggtgccacctgcgtgaagaagtgtccccgtaattatgtg gtgacagatcacggctcgtgcgtccgagcctgtggggccgacagctatgagatggaggaa gacggcgtccgcaagtgtaagaagtgcgaagggccttgccgcaaagtgtgtaacggaata ggtattggtgaatttaaagactcactctccataaatgctacgaatattaaacacttcaaa aactgcacctccatcagtggcgatctccacatcctgccggtggcatttaggggtgactcc ttcacacatactcctcctctggatccacaggaactggatattctgaaaaccgtaaaggaa atcacagggtttttgctgattcaggcttggcctgaaaacaggacggacctccatgccttt gagaacctagaaatcatacgcggcaggaccaagcaacatggtcagttttctcttgcagtc gtcagcctgaacataacatccttgggattacgctccctcaaggagataagtgatggagat gtgataatttcaggaaacaaaaatttgtgctatgcaaatacaataaactggaaaaaactg tttgggacctccggtcagaaaaccaaaattataagcaacagaggtgaaaacagctgcaag gccacaggccaggtctgccatgccttgtgctcccccgagggctgctggggcccggagccc agggactgcgtctcttgccggaatgtcagccgaggcagggaatgcgtggacaagtgcaac cttctggagggtgagccaagggagtttgtggagaactctgagtgcatacagtgccaccca gagtgcctgcctcaggccatgaacatcacctgcacaggacggggaccagacaactgtatc cagtgtgcccactacattgacggcccccactgcgtcaagacctgcccggcaggagtcatg ggagaaaacaacaccctggtctggaagtacgcagacgccggccatgtgtgccacctgtgc catccaaactgcacctacggatgcactgggccaggtcttgaaggctgtccaacgaatggg cctaagatcccgtccatcgccactgggatggtgggggccctcctcttgctgctggtggtg gccctggggatcggcctcttcatgcgaaggcgccacatcgttcggaagcgcacgctgcgg aggctgctgcaggagagggagcttgtggagcctcttacacccagtggagaagctcccaac caagctctcttgaggatcttgaaggaaactgaattcaaaaagatcaaagtgctgggctcc ggtgcgttcggcacggtgtataagggactctggatcccagaaggtgagaaagttaaaatt cccgtcgctatcaaggaattaagagaagcaacatctccgaaagccaacaaggaaatcctc gatgaagcctacgtgatggccagcgtggacaacccccacgtgtgccgcctgctgggcatc tgcctcacctccaccgtgcagctcatcacgcagctcatgcccttcggctgcctcctggac tatgtccgggaacacaaagacaatattggctcccagtacctgctcaactggtgtgtgcag atcgcaaagggcatgaactacttggaggaccgtcgcttggtgcaccgcgacctggcagcc aggaacgtactggtgaaaacaccgcagcatgtcaagatcacagattttgggctggccaaa ctgctgggtgcggaagagaaagaataccatgcagaaggaggcaaagtgcctatcaagtgg atggcattggaatcaattttacacagaatctatacccaccagagtgatgtctggagctac ggggtgaccgtttgggagttgatgacctttggatccaagccatatgacggaatccctgcc agcgagatctcctccatcctggagaaaggagaacgcctccctcagccacccatatgtacc atcgatgtctacatgatcatggtcaagtgctggatgatagacgcagatagtcgcccaaag ttccgtgagttgatcatcgaattctccaaaatggcccgagacccccagcgctaccttgtc attcagggggatgaaagaatgcatttgccaagtcctacagactccaacttctaccgtgcc ctgatggatgaagaagacatggacgacgtggtggatgccgacgagtacctcatcccacag cagggcttcttcagcagcccctccacgtcacggactcccctcctgagctctctgagtgca accagcaacaattccaccgtggcttgcattgatagaaatgggctgcaaagctgtcccatc aaggaagacagcttcttgcagcgatacagctcagaccccacaggcgccttgactgaggac agcatagacgacaccttcctcccagtgcctgaatacataaaccagtccgttcccaaaagg cccgctggctctgtgcagaatcctgtctatcacaatcagcctctgaaccccgcgcccagc agagacccacactaccaggacccccacagcactgcagtgggcaaccccgagtatctcaac actgtccagcccacctgtgtcaacagcacattcgacagccctgcccactgggcccagaaa ggcagccaccaaattagcctggacaaccctgactaccagcaggacttctttcccaaggaa gccaagccaaatggcatctttaagggctccacagctgaaaatgcagaatacctaagggtc gcgccacaaagcagtgaatttattggagcatga |
Protein Sequence |
>1956 : length: 1210 MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV APQSSEFIGA |