| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 1956 |
Name | EGFR |
Synonymous | ERBB|ERBB1|HER1|PIG61|mENA;epidermal growth factor receptor;EGFR;epidermal growth factor receptor |
Definition | avian erythroblastic leukemia viral (v-erb-b) oncogene homolog|cell growth inhibiting protein 40|cell proliferation-inducing protein 61|proto-oncogene c-ErbB-1|receptor tyrosine-protein kinase erbB-1 |
Position | 7p12 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr7:55086714-55324313 | chr7:55238268-55238268 | rs10228436 | Single_Nucleotides|eQTL|GBAS, Chromatin_Structure|DNase-seq|Huh75 | chr7:55086714-55324313 | chr7:55239979-55239979 | rs2241054 | Single_Nucleotides|eQTL|GBAS, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|Hffmyc, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Hrpe, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Skmc, Chromatin_Structure|DNase-seq|Myometr | chr7:55086714-55324313 | chr7:55242609-55242609 | rs2017000 | Single_Nucleotides|eQTL|GBAS, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|FAIRE|Nhbe, Chromatin_Structure|DNase-seq|Panislets | chr7:55086714-55324313 | chr7:55245364-55245364 | rs9642391 | Single_Nucleotides|eQTL|GBAS, Motifs|PWM|Mafb, Chromatin_Structure|DNase-seq|Huh7, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|UrotsaUt189, Chromatin_Structure|DNase-seq|Urotsa, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Medullo, Chromatin_Structure|FAIRE|Hepg2, Chromatin_Structure|FAIRE|UrotsaUt189, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Hepg2, Chromatin_Structure|DNase-seq|Fibrobl, Chromatin_Structure|DNase-seq|Gm12891, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|Chorion, Protein_Binding|ChIP-seq|TCF4, Protein_Binding|ChIP-seq|HEY1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|AR | chr7:55086714-55324313 | chr7:55245507-55245507 | rs845552 | Single_Nucleotides|eQTL|CHCHD2, Chromatin_Structure|DNase-seq|Huh7, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|UrotsaUt189, Chromatin_Structure|DNase-seq|Urotsa, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Medullo, Chromatin_Structure|FAIRE|Hepg2, Chromatin_Structure|FAIRE|UrotsaUt189, Chromatin_Structure|DNase-seq|Melano, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|FAIRE|Nhbe, Chromatin_Structure|DNase-seq|Caco2, Chromatin_Structure|DNase-seq|Ag10803, Chromatin_Structure|DNase-seq|Osteobl, Chromatin_Structure|DNase-seq|Ips, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Nha, Chromatin_Structure|DNase-seq|Nhlf, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hpf, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Aoaf, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Hepg2, Chromatin_Structure|DNase-seq|Fibrobl, Chromatin_Structure|DNase-seq|Gm12891, Protein_Binding|ChIP-seq|HDAC2, Protein_Binding|ChIP-seq|EP300, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|BHLHE40, Protein_Binding|ChIP-seq|FOXA1, Protein_Binding|ChIP-seq|FOXA1, Protein_Binding|ChIP-seq|FOXA2, Protein_Binding|ChIP-seq|FOSL2, Protein_Binding|ChIP-seq|ELF1, Protein_Binding|ChIP-seq|EP300, Protein_Binding|ChIP-seq|RAD21, Protein_Binding|ChIP-seq|RXRA, Protein_Binding|ChIP-seq|SP1, Protein_Binding|ChIP-seq|TCF12, Protein_Binding|ChIP-seq|FOXA1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|TBP, Protein_Binding|ChIP-seq|TCF4, Protein_Binding|ChIP-seq|HEY1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|AR |
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Transcription Factors [Top] |
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Regulation From TransFac database |
ErbB1(h) + Cdc25A(h) <==> ErbB1(h):Cdc25A(h) (binding) | HB-EGF(h) + ErbB1(h) <==> HB-EGF(h):ErbB1(h) (binding) | EGF(h) + ErbB1(h) <==> EGF(h):ErbB1(h) (binding) | ErbB1(h) + PI3K-C2alpha(h) <==> ErbB1(h):PI3K-C2alpha(h) (binding) | ErbB1(h) + PI3K-C2beta(h) <==> ErbB1(h):PI3K-C2beta(h) (binding) | ErbB1(h) + STAT1(h) <==> ErbB1(h):STAT1(h) (binding) | ErbB1(h) + STAT3(h) <==> ErbB1(h):STAT3(h) (binding) | ErbB1(h) + Src(h) <==> ErbB1(h):Src(h) (binding) | ErbB1(h) + Jak2(h) <==> ErbB1(h):Jak2(h) (binding) | ErbB1(h) + ubiquitin(h) --c-Cbl(h),UbcH7(h)--> ErbB1(h){ub} (ubiquitination) | ErbB1(h) + ubiquitin(h) --c-Cbl(h)--> ErbB1(h){ub} (ubiquitination) | ErbB1(h) + c-Cbl(h) <==> ErbB1(h):c-Cbl(h) (binding) | ErbB1(h) + 2 ubiquitin(v.s.) --Cbl-b(h)--> ErbB1(h){ub(1)}{ub(1)} (ubiquitination) | ErbB1(h) + 2 ubiquitin(v.s.) --c-Cbl(h)--> ErbB1(h){ub(1)}{ub(1)} (ubiquitination) | ErbB1(h) + Pyk2-isoform1(h) <==> ErbB1(h):Pyk2-isoform1(h) (binding) | ErbB1(h) + ARF4(h) <==> ErbB1(h):ARF4(h) (binding) | ErbB1(h) + CIN85(h) <==> ErbB1(h):CIN85(h) (binding) | ErbB1(h) + endophilin 1(h) <==> ErbB1(h):endophilin 1(h) (binding) | ErbB1(h) + ATP --> ErbB1(h){pY1092} + ADP (phosphorylation; automodification) | ErbB1(h) + 2 ATP --> ErbB1(h){pY869}{pY1172} + 2 ADP (phosphorylation) | ErbB1(h) + Decorin(h) <==> Decorin(h):ErbB1(h) (binding) | NHERF-1(h) + ErbB1(h) <==> NHERF-1(h):ErbB1(h) (binding) | 2 ErbB1(h) <==> (ErbB1(h))2 (oligomerization) | ErbB1(h) + ATP --> ErbB1(h){pY} + ADP (phosphorylation) | ErbB2(m.s.) + ErbB1(h) <==> ErbB2(m.s.):ErbB1(h) (binding) | 3 ErbB1(h) <==> (ErbB1(h))3 (binding) | ErbB1(h) + caveolin-1(h) <==> ErbB1(h):caveolin-1(h) (binding) | caveolin-1(ca) + ErbB1(h) <==> caveolin-1(ca):ErbB1(h) (binding) | STAM2(m) + ErbB1(h) <==> STAM2(m):ErbB1(h) (binding) | Eps8(m) + ErbB1(h) <==> Eps8(m):ErbB1(h) (binding) | ErbB1(h) + Eps8(m) <==> ErbB1(h):Eps8(m) (binding) | ErbB2(h) + ErbB1(h) <==> ErbB1(h):ErbB2(h) (binding) | ErbB1(h) + ErbB2(h){pY1222} <==> ErbB1(h):ErbB2(h){pY1222} (binding) | ErbB2(h){pY1248} + ErbB1(h) <==> ErbB2(h){pY1248}:ErbB1(h) (binding) | LRIG1-xbb1(h) + ErbB1(h) <==> LRIG1-xbb1(h):ErbB1(h) (binding) | ErbB1(h) + ubiquitin(h) --> ErbB1(h){ub} (ubiquitination) | ErbB1(h) + 6 ATP --> ErbB1(h){pT678}{pT693}{pS991}{pS1026}{pY1172}{pY1197} + 6 ADP (phosphorylation) | ErbB1(h) + ATP --> ErbB1(h){pY1016} + ADP (phosphorylation; automodification) | ErbB1(h) + ATP --Cdk1(x)--> ErbB1(h){pS1026} + ADP (phosphorylation) | ErbB1(h) + PTPRK(h) <==> PTPRK(h):ErbB1(h) (binding) | ErbB1(h) + 2 ATP --CaMKII(r)--> ErbB1(h){pS1070}{pS1071} + 2 ADP (phosphorylation) | ErbB1(h) + 3 ATP --> ErbB1(h){pS991}{pY998}{pY1172} + 3 ADP (phosphorylation) | ErbB1(h) + 12 NDP-Gly --> ErbB1(h){glyN56}{glyN128}{glyN175}{glyN196}{glyN352}{glyN361}{glyN413}{glyN444}{glyN528}{glyN568}{glyN603}{glyN623} + 12 NMP (glycosylation) | ErbB1(h) + 13 ATP --> ErbB1(h){pT693}{pS991}{pY1016}{pS1026}{pY1069}{pS1070}{pS1081}{pY1092}{pY1110}{pY1138}{pS1166}{pY1172}{pY1197} + 13 ADP (phosphorylation) | MRP-14(h) + ErbB1(h) <==> MRP-14(h):ErbB1(h) (binding) | CD98(h) + ErbB1(h) <==> CD98(h):ErbB1(h) (binding) | ErbB1(h) + clathrin LCa(h) <==> ErbB1(h):clathrin LCa(h) (binding) | ErbB1(h) + GAPD(h) <==> ErbB1(h):GAPD(h) (binding) | Grb-2(h) + ErbB1(h) <==> Grb-2(h):ErbB1(h) (binding) | ErbB1(h) + Lyn(h) <==> ErbB1(h):Lyn(h) (binding) | ErbB1(h) + 14-3-3sigma(h) <==> ErbB1(h):14-3-3sigma(h) (binding) | SHP1-isoform2(h) + ErbB1(h) <==> SHP1-isoform2(h):ErbB1(h) (binding) | ErbB1(h) + ATP --betaARK-1(b)--> ErbB1(h){pS} + ADP (phosphorylation) | ErbB1(h) + 3 ATP --> ErbB1(h){pY1092}{pY1110}{pY1197} + 3 ADP (phosphorylation; automodification) | p85alpha(h) + ErbB1(h) <==> p85alpha(h):ErbB1(h) (binding) | YMER-isoform1(h) + ErbB1(h) <==> YMER-isoform1(h):ErbB1(h) (binding) | ErbB1(h) + ubiquitin(h) --c-Cbl(h)--> ErbB1(h){ub} (ubiquitination) | ErbB1(h) + ubiquitin(h) --Cbl-b(h)--> ErbB1(h){ub} (ubiquitination) | ErbB1(h) + ubiquitin(h) --CBL-3L(h)--> ErbB1(h){ub} (ubiquitination) | ErbB1(h) + ubiquitin(h) --c-Cbl(h),Ubc5B(h),E1(h)--> ErbB1(h){ub} (ubiquitination) | ErbB1(h) + ubiquitin(h) --E1(h),Ubc5C(h),c-Cbl(h)--> ErbB1(h){ub} (ubiquitination) | ErbB1(h) + 3 ATP --> ErbB1(h){pS}{pT}{pY} + 3 ADP (phosphorylation) | ErbB1(h) + 5 ATP --> ErbB1(h){pY869}{pY1016}{pY1069}{pY1092}{pY1197} + 5 ADP (phosphorylation) | ErbB1(h) + DNA-PKcs(h) <==> ErbB1(h):DNA-PKcs(h) (binding) | ErbB1(h) + Ku70(h):Ku80(h) <==> ErbB1(h):Ku70(h):Ku80(h) (binding) | ErbB1(h) + DNA-PKcs(m) <==> ErbB1(h):DNA-PKcs(m) (binding) | ErbB1(h) + Ku80(m):Ku70(m) <==> ErbB1(h):Ku80(m):Ku70(m) (binding) | ErbB1(h) + ATP --> ErbB1(h){pY} + ADP (phosphorylation; automodification) | p85alpha(m.s.) + ErbB1(h) <==> p85alpha(m.s.):ErbB1(h) (binding) | p85beta(m.s.) + ErbB1(h) <==> p85beta(m.s.):ErbB1(h) (binding) | Syk(h) + ErbB1(h) <==> Syk(h):ErbB1(h) (binding) | ErbB1(h) + CAML(h) <==> ErbB1(h):CAML(h) (binding) | ErbB1(h) + 3 ATP --> ErbB1(h){pY869}{pY1092}{pY1197} + 3 ADP (phosphorylation; automodification) | ErbB1(h) + STAT5A(h) <==> ErbB1(h):STAT5A(h) (binding) | ErbB1(h) + STAT5B(h) <==> ErbB1(h):STAT5B(h) (binding) | ErbB1(h) + 4 ATP --> ErbB1(h){pY1092}{pY1110}{pY1172}{pY1197} + 4 ADP (phosphorylation) | ErbB1(h) + ATP --> ErbB1(h){pY1197} + ADP (phosphorylation) | ErbB1(h){pY1197} + ErbB1(h) <==> ErbB1(h){pY1197}:ErbB1(h) (binding) | ErbB1(h) + ErbB2(h) <==> ErbB1(h):ErbB2(h) (binding) | ErbB1(h) + ErbB2(h){pY1248} <==> ErbB1(h):ErbB2(h){pY1248} (binding) | ErbB1(h) + CD44(h) <==> ErbB1(h):CD44(h) (binding) | Src(m) + ErbB1(h) <==> Src(m):ErbB1(h) (binding) | ErbB1(h) + 2 ATP --> ErbB1(h){pY869}{pY1092} + 2 ADP (phosphorylation) | ErbB1(h) + PLSCR1(h) <==> ErbB1(h):PLSCR1(h) (binding) | ErbB1(h) --> protein remnants (degradation) | ErbB1(h) + Shc(m) + Grb-2(m) <==> ErbB1(h):Shc(m):Grb-2(m) (binding) | ErbB1(h) + ErbB2(h) + CD44(h) <==> ErbB1(h):ErbB2(h):CD44(h) (binding) | Eps8(h) + ErbB1(h) <==> Eps8(h):ErbB1(h) (binding) | ErbB1(h) + Shc-1-p66(h) <==> ErbB1(h):Shc-1-p66(h) (binding) | ErbB1(h) + Shc-1-p52(h) <==> ErbB1(h):Shc-1-p52(h) (binding) | ErbB1(h) + Shc-1-p46(h) <==> ErbB1(h):Shc-1-p46(h) (binding) | ErbB1(h) + Pyk2(h) <==> ErbB1(h):Pyk2(h) (binding) | ErbB1(h) + ErbB3(h) <==> ErbB1(h):ErbB3(h) (binding) | ErbB1(h) + ErbB4(h) <==> ErbB1(h):ErbB4(h) (binding) | ErbB1(h) + CBL-3L(h) <==> ErbB1(h):CBL-3L(h) (binding) | ErbB1(h) + STAT1alpha(h) <==> ErbB1(h):STAT1alpha(h) (binding) | ErbB1(h) + STAT1beta(h) <==> ErbB1(h):STAT1beta(h) (binding) | ErbB1(h) + PDGFRbeta(h) <==> ErbB1(h):PDGFRbeta(h) (binding) | ErbB1(h) + PDGFRbeta(h) <==> ErbB1(h):PDGFRbeta(h) (binding) | ErbB1(h) + proEPR(h) <==> ErbB1(h):proEPR(h) (binding) | ErbB1(h) --> ErbB1(h) (translocation) | ErbB1(h) + eps15(m.s.) <==> ErbB1(h):eps15(m.s.) (binding) | ErbB1(h) + epsin 1(m.s.) <==> ErbB1(h):epsin 1(m.s.) (binding) | ErbB1(h) + n ubiquitin(h) --> ErbB1(h){ub}n (ubiquitination) | ErbB1(h) + c-Cbl(m) <==> ErbB1(h):c-Cbl(m) (binding) | ErbB1(h) + Cbl-b(m) <==> ErbB1(h):Cbl-b(m) (binding) | ErbB1(h) + Grb-2(m.s.) <==> ErbB1(h):Grb-2(m.s.) (binding) | ErbB1(h) + Shc-1-p66(m) <==> ErbB1(h):Shc-1-p66(m) (binding) | ErbB1(h) + Shc-1-p46(m) <==> ErbB1(h):Shc-1-p46(m) (binding) | ErbB1(h) + BTC(h) <==> ErbB1(h):BTC(h) (binding) | ErbB1(h) + ATP --> ErbB1(h){p} + ADP (phosphorylation) | ErbB1(h) + HPRG(m.s.) <==> ErbB1(h):HPRG(m.s.) (binding) | Src(h){pY419} + ErbB1(h) <==> Src(h){pY419}:ErbB1(h) (binding) | ErbB1(h) + ER-alpha(h) <==> ErbB1(h):ER-alpha(h) (binding) | ErbB1(h) --> stromelysin1(h) (increase of abundance) | ErbB1(h) + 4 ATP --> ErbB1(h){pY869}{pY1016}{pY1069}{pY1092} + 4 ADP (phosphorylation) | ErbB1(h) + IGF-1R(h) <==> ErbB1(h):IGF-1R(h) (binding) | ErbB1(h) + p85(h) <==> ErbB1(h):p85(h) (binding) | ErbB1(h) + ATP --> ErbB1(h){pY869} + ADP (phosphorylation) | ErbB1(h) --/ Notch1(h) (decrease of abundance) | ErbB1(h) --/ HES1(h) (transrepression) | ErbB1(h) --/ NOTCH1(h) (transrepression) | ErbB1(h) --/ TP53(h) (transrepression) | ErbB1(h) --/ KRT1(h) (transrepression) | ErbB1(h) --/ KRT10(h) (transrepression) | ErbB1(h) --/ IVL(h) (transrepression) | ErbB1(h) --/ Keratin-1(h) (decrease of abundance) | ErbB1(h) --/ involucrin(h) (decrease of abundance) | ErbB1(h){pY} --Cdc25A(m.s.)--> ErbB1(h) + p (dephosphorylation) | c-Jun(h) --> ErbB1(h) (increase of abundance) | ErbB1(h){pY1092}{pY1197}{pY1016} --PTPRK(h)--> ErbB1(h) + p (dephosphorylation) | ErbB1(h){pY} --SHP1-isoform2(h)--> ErbB1(h) + p (dephosphorylation) | ErbB1(h){pY} --SHP-1(h)--> ErbB1(h) + p (dephosphorylation) | ErbB1(h) --> ErbB1(h) (translocation) | EGFR(h) --> ErbB1(h) (expression). | YB-1(m.s.) --> ErbB1(h) (increase of abundance) | YB-1(h) --> ErbB1(h) (increase of abundance) | eps15(m) + ATP --ErbB1(h)--> eps15(m){pY} + ADP (phosphorylation) | STAM2(m.s.) + ATP --ErbB1(h)--> STAM2(m.s.){pY} + ADP (phosphorylation) | eps15(m) + ATP --ErbB1(h)--> eps15(m){pY} + ADP (phosphorylation) | Eps8(m) + ATP --ErbB1(h)--> Eps8(m){pY} + ADP (phosphorylation) | EGFR(h) --> ErbB1-p60(h) (expression). | EGFR(h) --> ErbB1-p110(h) (expression). | ErbB1-p170(h) + NHERF-1(m) <==> NHERF-1(m):ErbB1-p170(h) (binding) | ErbB1-p170(h) + NHERF-1(m.s.) <==> NHERF-1(m.s.):ErbB1-p170(h) (binding) | 2 ErbB1-p170(h) <==> (ErbB1-p170(h))2 (oligomerization) | ErbB1-p170(h) + ATP --> ErbB1-p170(h){pY} + ADP (phosphorylation; automodification) | ErbB2(h) + ErbB1-p170(h) <==> ErbB2(h):ErbB1-p170(h) (binding) | ErbB1-p170(h) + caveolin-1(ca) <==> ErbB1-p170(h):caveolin-1(ca) (binding) | ErbB1-p170(h) + ATP --> ErbB1-p170(h){p} + ADP (phosphorylation; automodification) | ErbB1-p170(h) + 2 ATP --> ErbB1-p170(h){pY869}{pY1125} + 2 ADP (phosphorylation) | ErbB1-p170(h) + 6 ubiquitin(h) --> ErbB1-p170(h){ubK716}{ubK737}{ubK754}{ubK867}{ubK929}{ubK970} (ubiquitination) | ErbB1-p170(h) + n ubiquitin(h) --> ErbB1-p170(h){ub(n)} (ubiquitination) | ErbB1-p170(h) + ATP --> ErbB1-p170(h){pY1110} + ADP (phosphorylation) | ErbB1-p170(h) + ATP --Src(h)--> ErbB1-p170(h){pY869} + ADP (phosphorylation) | ErbB1-p170(h) + p56Dok-2(h) <==> p56Dok-2(h):ErbB1-p170(h) (binding) | ErbB1-p170(h) + fer(h) <==> ErbB1-p170(h):fer(h) (binding) | ErbB1-p170(h) + PTK6(h) <==> ErbB1-p170(h):PTK6(h) (binding) | ErbB1-p170(h) + RGS12(h) <==> ErbB1-p170(h):RGS12(h) (binding) | ErbB1-p170(h) + SH2D1A(h) <==> ErbB1-p170(h):SH2D1A(h) (binding) | ErbB1-p170(h) + 7 ATP --Src(h)--> ErbB1-p170(h){pY915}{pY944}{pY1016}{pY1092}{pY1110}{pY1172}{pY1197} + 7 ADP (phosphorylation) | ErbB1-p170(h) + 3 ATP --Abl(m)--> ErbB1-p170(h){pY1016}{pY1092}{pY1197} + 3 ADP (phosphorylation) | ErbB1-p170(h) + c-Cbl(m.s.) <==> c-Cbl(m.s.):ErbB1-p170(h) (binding) | ErbB1-p170(h) + ubiquitin(h) --> ErbB1-p170(h){ub} (ubiquitination) | ErbB1-p170(h) + 5 ATP --> ErbB1-p170(h){pY1016}{pY1092}{pY1110}{pY1172}{pY1197} + 5 ADP (phosphorylation; automodification) | ErbB1-p170(h) + 4 ATP --> ErbB1-p170(h){pT678}{pT693}{pS1070}{pS1071} + 4 ADP (phosphorylation) | ErbB1-p170(h) + ATP --> ErbB1-p170(h){pY1197} + ADP (phosphorylation) | ErbB1-p170(h) + ATP --> ErbB1-p170(h){pY1092} + ADP (phosphorylation) | ErbB1-p170(h) --> protein remnants (degradation) | ErbB1-p170(h) + PLCgamma1(m) <==> ErbB1-p170(h):PLCgamma1(m) (binding) | ErbB1-p170(h) + ATP --> ErbB1-p170(h){pY1069} + ADP (phosphorylation) | ErbB1-p170(h) + ATP --> ErbB1-p170(h){pY1069} + ADP (automodification; phosphorylation) | EGFR(h) --> ErbB1-p170(h) (expression). | crkII(h) + ATP --ErbB1-p170(h)--> crkII(h){pY221} + ADP (phosphorylation) | ErbB4-JM-A(h) + 10 ATP --ErbB1-p170(h)--> ErbB4-JM-A(h){pY1022}{pY1056}{pY1150}{pY1162}{pY1188}{pY1202}{pY1221}{pY1242}{pY1258}{pY1284} + 10 ADP (phosphorylation) | ErbB3-isoform1(h) + 11 ATP --ErbB1-p170(h)--> ErbB3-isoform1(h){pY1054}{pY1159}{pY1197}{pY1199}{pY1222}{pY1224}{pY1260}{pY1262}{pY1276}{pY1289}{pY1328} + 11 ADP (phosphorylation) | ErbB2(h) + 7 ATP --ErbB1-p170(h)--> ErbB2(h){pY1023}{pY1127}{pY1139}{pY1196}{pY1221}{pY1222}{pY1248} + 7 ADP (phosphorylation) | ErbB3(r) + ATP --ErbB1-p170(h)--> ErbB3(r){pY} + ADP (phosphorylation) | EGFR(h) --> ErbB1-4(h) (expression). | EGFR(h) --> EGFR(h) (expression). | hsa-miR-7 --/ EGFR(h) (translational repression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
128 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 175 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 196 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 352 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 361 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 413 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 444 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 528 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 568 | N-linked (GlcNAc...); partial. | Swiss-Prot 53.0 | 603 | N-linked (GlcNAc...); partial. | Swiss-Prot 53.0 | 678 | Phosphothreonine; by PKC. | Swiss-Prot 53.0 | 693 | Phosphothreonine. | Swiss-Prot 53.0 | 695 | Phosphoserine. | Swiss-Prot 53.0 | 978 | Phosphotyrosine. | Swiss-Prot 53.0 | 991 | Phosphoserine. | Swiss-Prot 53.0 | 995 | Phosphoserine. | Swiss-Prot 53.0 | 998 | Phosphotyrosine. | Swiss-Prot 53.0 | 1026 | Phosphoserine. | Swiss-Prot 53.0 | 1064 | Phosphoserine. | Swiss-Prot 53.0 | 1069 | Phosphotyrosine. | Swiss-Prot 53.0 | 1070 | Phosphoserine. | Swiss-Prot 53.0 | 1071 | Phosphoserine. | Swiss-Prot 53.0 | 1092 | Phosphotyrosine; by autocatalysis. | Swiss-Prot 53.0 | 1110 | Phosphotyrosine; by autocatalysis. | Swiss-Prot 53.0 | 1138 | Phosphotyrosine. | Swiss-Prot 53.0 | 1166 | Phosphoserine. | Swiss-Prot 53.0 | 1172 | Phosphotyrosine; by autocatalysis. | Swiss-Prot 53.0 | 1197 | Phosphotyrosine; by autocatalysis. | Swiss-Prot 53.0 | 716 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 737 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 754 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 867 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 929 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 970 | Glycyl lysine isopeptide (Lys-Gly)(interchain with G-Cter in ubiquitin). | Swiss-Prot 53.0 | 1110 | Phosphotyrosine (EGFR) | 8845374;15302935 | Phospho.ELM 6.0 | 1197 | Phosphotyrosine (EGFR) | 8845374;15302935;17081983 | Phospho.ELM 6.0 | 1125 | Phosphotyrosine (Src) | 8845374;11983694;10075741 | Phospho.ELM 6.0 | 1172 | Phosphotyrosine (EGFR) | 8845374;15302935;17081983 | Phospho.ELM 6.0 | 1092 | Phosphotyrosine (EGFR) | 8845374;15302935;17081983 | Phospho.ELM 6.0 | 1016 | Phosphotyrosine (EGFR) | 8845374;7680558;15302935 | Phospho.ELM 6.0 | 1070 | Phosphoserine (CaM-KIIalpha) | 92065884;15302935;10347170;7805884;1309762;3138233 | Phospho.ELM 6.0 | 1071 | Phosphoserine (CaM-KIIalpha) | 92065884;15302935;10347170;7805884;1309762;3138233 | Phospho.ELM 6.0 | 695 | Phosphoserine | 92065884;15302935 | Phospho.ELM 6.0 | 678 | Phosphothreonine (PKC alpha;PK) | 85012702;15302935;6090944;1860884;3379075 | Phospho.ELM 6.0 | 693 | Phosphothreonine (ERT PK;MAPK1) | 91332050;15302935;1939237;3138233;2115882;2543683; | Phospho.ELM 6.0 | 944 | Phosphotyrosine (Src) | 11983694 | Phospho.ELM 6.0 | 915 | Phosphotyrosine (Src) | 11983694 | Phospho.ELM 6.0 | 869 | Phosphotyrosine (Src) | 11983694;10075741 | Phospho.ELM 6.0 | 768 | Phosphoserine (CaM-KIIalpha) | 15302935;10347170 | Phospho.ELM 6.0 | 1026 | Phosphoserine (CDK1) | 15302935;8360196 | Phospho.ELM 6.0 | 1028 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 1069 | Phosphotyrosine | 15302935;17081983 | Phospho.ELM 6.0 | 1081 | Phosphoserine (CaM-KIIalpha) | 15302935;10347170 | Phospho.ELM 6.0 | 1166 | Phosphoserine (CaM-KIIalpha) | 15302935;10347170 | Phospho.ELM 6.0 | 1190 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 978 | Phosphotyrosine | 16097034 | Phospho.ELM 6.0 | 991 | Phosphoserine | 15901825;17081983 | Phospho.ELM 6.0 | 998 | Phosphotyrosine | 15951569;17081983 | Phospho.ELM 6.0 | 1039 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1042 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1045 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1064 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 1104 | Phosphoserine | 17081983 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 55052719 - 55054719 | Agilent_014791 |
chr7 |
Promoter: 55052719 - 55054719 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 55052719 - 55054719 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 55052719 - 55054719 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 55052719 - 55054719 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 55052719 - 55054719 | GSE27584 |
chr7 |
Promoter: 55052719 - 55054719 | GSE27584 |
chr7 |
Promoter: 55052719 - 55054719 | GSE27584 |
chr7 |
Promoter: 55052719 - 55054719 | GSE27584 |
chr7 |
Promoter: 55052719 - 55054719 | Agilent_014791_44K |
chr7 |
Promoter: 55052719 - 55054719 | PMID:17369752 |
chr7 |
Promoter: 55052719 - 55054719 | PMID:17369752 |
chr7 |
Promoter: 55052719 - 55054719 | PMID:17369752 |
chr7 |
Promoter: 55052719 - 55054719 | PMID:17369752 |