| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 207 |
Name | AKT1 |
Synonym | AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA;v-akt murine thymoma viral oncogene homolog 1;AKT1;v-akt murine thymoma viral oncogene homolog 1 |
Definition | PKB alpha|RAC-PK-alpha|RAC-alpha serine/threonine-protein kinase|protein kinase B alpha|proto-oncogene c-Akt|rac protein kinase alpha |
Position | 14q32.32 |
Gene Type | protein-coding |
|
PAH Type |
Description |
PAH | "The results showed that MCT induced pulmonary arterial remodeling, raised the serotonylation and membrane translocation of RhoA in the lungs, and increased serotonin transporter (5-HTT), RhoA, and ROCK2 expression, and extracellular signal-regulated kinase (ERK) and Akt phosphorylation in the pulmonary arteries and the lungs." |
PAH | "The results showed that MCT induced pulmonary arterial remodeling, raised the serotonylation and membrane translocation of RhoA in the lungs, and increased serotonin transporter (5-HTT), RhoA, and ROCK2 expression, and extracellular signal-regulated kinase (ERK) and Akt phosphorylation in the pulmonary arteries and the lungs." |
| More detail of all Rat literatures about AKT1 | |
|
Pathways and Diseases |
|
Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | il-2 receptor beta chain in t cell activation;PID BioCarta;100129 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | role of erbb2 in signal transduction and oncology;PID BioCarta;100147 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Endometrial cancer;KEGG PATHWAY;hsa05213 |
Pathway | mtor signaling pathway;PID BioCarta;100101 |
Pathway | VEGFR1 specific signals;PID Curated;200151 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Regulation of beta-cell development;Reactome;REACT:13698 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages;PID BioCarta;100152 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | eNOS activation;PID Reactome;500849 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Pathway | Hedgehog signaling events mediated by Gli proteins;PID Curated;200147 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | Progesterone-mediated oocyte maturation;KEGG PATHWAY;hsa04914 |
Pathway | S1P3 pathway;PID Curated;200035 |
Pathway | Aurora A signaling;PID Curated;200166 |
Pathway | E-cadherin signaling in the nascent adherens junction;PID Curated;200105 |
Pathway | Huntington disease;PANTHER;P00029 |
Pathway | nfat and hypertrophy of the heart ;PID BioCarta;100098 |
Pathway | b cell survival pathway;PID BioCarta;100228 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | regulation of bad phosphorylation;PID BioCarta;100233 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | IL2 signaling events mediated by PI3K;PID Curated;200099 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | Coregulation of Androgen receptor activity;PID Curated;200038 |
Pathway | trka receptor signaling pathway;PID BioCarta;100011 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | Nephrin/Neph1 signaling in the kidney podocyte;PID Curated;200132 |
Pathway | Negative regulation of the PI3K/AKT network;PID Reactome;500642 |
Pathway | AKT-mediated inactivation of FOXO1A;PID Reactome;500523 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | BCR signaling pathway;PID Curated;200005 |
Pathway | human cytomegalovirus and map kinase pathways;PID BioCarta;100149 |
Pathway | p53 pathway;PID Curated;200175 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Activation of BAD and translocation to mitochondria;PID Reactome;500261 |
Pathway | CD40/CD40L signaling;PID Curated;200031 |
Pathway | CXCR3-mediated signaling events;PID Curated;200150 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Insulin/IGF pathway-protein kinase B signaling cascade;PANTHER;P00033 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | phospholipids as signalling intermediaries;PID BioCarta;100183 |
Pathway | IGF1 pathway;PID Curated;200084 |
Pathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway;PID BioCarta;100137 |
Pathway | transcription factor creb and its extracellular signals;PID BioCarta;100198 |
Pathway | pten dependent cell cycle arrest and apoptosis;PID BioCarta;100058 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | AKT phosphorylates targets in the nucleus;PID Reactome;500641 |
Pathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis;PID BioCarta;100255 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Pathway | influence of ras and rho proteins on g1 to s transition;PID BioCarta;100054 |
Pathway | CTLA4 inhibitory signaling;PID Reactome;500487 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | p53 pathway by glucose deprivation;PANTHER;P04397 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | PI3K/AKT signalling;PID Reactome;500639 |
Pathway | telomeres telomerase cellular aging and immortality;PID BioCarta;100021 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | trefoil factors initiate mucosal healing;PID BioCarta;100018 |
Pathway | p75(NTR)-mediated signaling;PID Curated;200103 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Nongenotropic Androgen signaling;PID Curated;200145 |
Pathway | mTOR signaling pathway;PID Curated;200080 |
Pathway | corticosteroids and cardioprotection;PID BioCarta;100156 |
Pathway | tumor suppressor arf inhibits ribosomal biogenesis;PID BioCarta;100237 |
Pathway | FGF signaling pathway;PID Curated;200189 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | FAS signaling pathway;PANTHER;P00020 |
Pathway | AKT phosphorylates targets in the cytosol;PID Reactome;500640 |
Pathway | Insulin Pathway;PID Curated;200012 |
Pathway | CD28 dependent PI3K/Akt signaling;PID Reactome;500485 |
Pathway | mTOR signaling pathway;KEGG PATHWAY;hsa04150 |
Pathway | ras signaling pathway;PID BioCarta;100047 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Pathway | actions of nitric oxide in the heart;PID BioCarta;100094 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Retinoic acid receptors-mediated signaling;PID Curated;200142 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Pathway | Ceramide signaling pathway;PID Curated;200100 |
Pathway | Metabolism of nitric oxide;Reactome;REACT:12508 |
Pathway | vegf hypoxia and angiogenesis;PID BioCarta;100006 |
Pathway | a6b1 and a6b4 Integrin signaling;PID Curated;200162 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Insulin-mediated glucose transport;PID Curated;200168 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | il 4 signaling pathway;PID BioCarta;100127 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | VEGFR3 signaling in lymphatic endothelium;PID Curated;200188 |
Pathway | ion channels and their functional role in vascular endothelium;PID BioCarta;100055 |
Pathway | akt signaling pathway;PID BioCarta;100245 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | IL4-mediated signaling events;PID Curated;200018 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Reelin signaling pathway;PID Curated;200051 |
Pathway | Carbohydrate digestion and absorption;KEGG PATHWAY;hsa04973 |
Pathway | role of erk5 in neuronal survival pathway;PID BioCarta;100171 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | PI3 kinase pathway;PANTHER;P00048 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | Insulin signaling pathway;KEGG PATHWAY;hsa04910 |
Pathway | Hypoxia response via HIF activation;PANTHER;P00030 |
Pathway | hypoxia and p53 in the cardiovascular system;PID BioCarta;100084 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | phosphoinositides and their downstream targets;PID BioCarta;100059 |
Pathway | Plasma membrane estrogen receptor signaling;PID Curated;200029 |
Pathway | Signaling events mediated by the Hedgehog family;PID Curated;200144 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | apoptotic signaling in response to dna damage;PID BioCarta;100204 |
Pathway | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk);PID BioCarta;100148 |
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | the igf-1 receptor and longevity;PID BioCarta;100115 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | FoxO family signaling;PID Curated;200091 |
Pathway | FOXA2 and FOXA3 transcription factor networks;PID Curated;200073 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | regulation of eif-4e and p70s6 kinase;PID BioCarta;100178 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | Ovarian cancer, somatic;OMIM |
Disease | Hyperglycemia;FunDO |
Disease | Cancer;FunDO |
Disease | Systemic scleroderma;FunDO |
Disease | Huntington disease;FunDO |
Disease | Colorectal cancer, somatic;OMIM |
Disease | Vitiligo;FunDO |
Disease | Polycystic ovary syndrome;FunDO |
Disease | Systemic infection;FunDO |
Disease | Schizophrenia;FunDO |
Disease | PSYCH;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | CHEMDEPENDENCY;GAD |
Disease | Psychotic disorder;FunDO |
Disease | Tropical spastic paraparesis;FunDO |
Disease | Adenovirus infection;FunDO |
Disease | Schizophrenia, susceptibility to;OMIM |
Disease | Breast cancer, somatic;OMIM |
Disease | Hypertension;FunDO |
Disease | methamphetamine abuse;GAD |
Disease | schizophrenia;GAD |
Disease | Obesity;FunDO |
Disease | Atherosclerosis;FunDO |
|
External Links |
|
Links to Entrez Gene | 207 |
Links to all GeneRIF Items | 207 |
Links to iHOP | 207 |
|
Sequence Information |
|
Nucleotide Sequence |
>207 : length: 1443 atgagcgacgtggctattgtgaaggagggttggctgcacaaacgaggggagtacatcaag acctggcggccacgctacttcctcctcaagaatgatggcaccttcattggctacaaggag cggccgcaggatgtggaccaacgtgaggctcccctcaacaacttctctgtggcgcagtgc cagctgatgaagacggagcggccccggcccaacaccttcatcatccgctgcctgcagtgg accactgtcatcgaacgcaccttccatgtggagactcctgaggagcgggaggagtggaca accgccatccagactgtggctgacggcctcaagaagcaggaggaggaggagatggacttc cggtcgggctcacccagtgacaactcaggggctgaagagatggaggtgtccctggccaag cccaagcaccgcgtgaccatgaacgagtttgagtacctgaagctgctgggcaagggcact ttcggcaaggtgatcctggtgaaggagaaggccacaggccgctactacgccatgaagatc ctcaagaaggaagtcatcgtggccaaggacgaggtggcccacacactcaccgagaaccgc gtcctgcagaactccaggcaccccttcctcacagccctgaagtactctttccagacccac gaccgcctctgctttgtcatggagtacgccaacgggggcgagctgttcttccacctgtcc cgggagcgtgtgttctccgaggaccgggcccgcttctatggcgctgagattgtgtcagcc ctggactacctgcactcggagaagaacgtggtgtaccgggacctcaagctggagaacctc atgctggacaaggacgggcacattaagatcacagacttcgggctgtgcaaggaggggatc aaggacggtgccaccatgaagaccttttgcggcacacctgagtacctggcccccgaggtg ctggaggacaatgactacggccgtgcagtggactggtgggggctgggcgtggtcatgtac gagatgatgtgcggtcgcctgcccttctacaaccaggaccatgagaagctttttgagctc atcctcatggaggagatccgcttcccgcgcacgcttggtcccgaggccaagtccttgctt tcagggctgctcaagaaggaccccaagcagaggcttggcgggggctccgaggacgccaag gagatcatgcagcatcgcttctttgccggtatcgtgtggcagcacgtgtacgagaagaag ctcagcccacccttcaagccccaggtcacgtcggagactgacaccaggtattttgatgag gagttcacggcccagatgatcaccatcacaccacctgaccaagatgacagcatggagtgt gtggacagcgagcgcaggccccacttcccccagttctcctactcggccagcggcacggcc tga |
Protein Sequence |
>207 : length: 480 MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA |