| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 207 |
Name | AKT1 |
Synonymous | AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA;v-akt murine thymoma viral oncogene homolog 1;AKT1;v-akt murine thymoma viral oncogene homolog 1 |
Definition | PKB alpha|RAC-PK-alpha|RAC-alpha serine/threonine-protein kinase|protein kinase B alpha|proto-oncogene c-Akt|rac protein kinase alpha |
Position | 14q32.32 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr14:105235686-105262088 | chr14:105237680-105237680 | rs2494731 | Single_Nucleotides|eQTL|NM_021709, Single_Nucleotides|eQTL|SIVA, Single_Nucleotides|eQTL|SIVA, Single_Nucleotides|eQTL|SIVA, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|Osteobl, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|DNase-seq|Gm19240, Chromatin_Structure|DNase-seq|Gm12891, Chromatin_Structure|DNase-seq|Gm19238, Chromatin_Structure|DNase-seq|Gm19239, Protein_Binding|ChIP-seq|SETDB1 | chr14:105235686-105262088 | chr14:105239146-105239146 | rs3803304 | Single_Nucleotides|eQTL|SIVA, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|Footprinting|E2A, Motifs|PWM|E2A, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|DNase-seq|Ips, Chromatin_Structure|DNase-seq|Osteobl, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|DNase-seq|Gm12891, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Nb4, Protein_Binding|ChIP-seq|POLR2A | chr14:105235686-105262088 | chr14:105242831-105242831 | rs3001371 | Single_Nucleotides|eQTL|SIVA, Motifs|Footprinting|RREB-1, Motifs|Footprinting|RREB1, Motifs|Footprinting|RREB1, Motifs|PWM|RREB1, Motifs|Footprinting|RREB1, Motifs|PWM|RREB1, Motifs|Footprinting|RREB-1, Motifs|PWM|RREB-1, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|Gm12891, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Osteobl, Protein_Binding|ChIP-seq|ZNF263 |
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Transcription Factors [Top] |
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Regulation From TransFac database |
AKT-1(h) + FOXO1A(h) <==> FOXO1A(h):AKT-1(h) (binding) | AKT-1(h) + NTP --PDK1(m){pS}--> AKT-1(h){pT308} + NDP (phosphorylation) | AKT-1(h) + ATP --mTOR(h):rictor(h)--> AKT-1(h){pS473} + ADP (phosphorylation) | AKT-1(h) + ATP --> AKT-1(h){pS473} + ADP (phosphorylation) | AKT-1(h) + ATP --PDK1(h)--> AKT-1(h){pT308} + ADP (phosphorylation) | AKT-1(h) + ER-beta(h) <==> AKT-1(h):ER-beta(h) (binding) | AR(h) + mdm2(h) + AKT-1(h) <==> AR(h):mdm2(h):AKT-1(h) (binding) | AR(h) + AKT-1(h) <==> AR(h):AKT-1(h) (binding) | AKT-1(h) + calmodulin(b) <==> AKT-1(h):calmodulin(b) (binding) | AKT-1(h) + calmodulin(h) <==> AKT-1(h):calmodulin(h) (binding) | ArgBP2(h) + AKT-1(h) <==> ArgBP2(h):AKT-1(h) (binding) | AKT-1(h) + Ft1(h) <==> AKT-1(h):Ft1(h) (binding) | AKT-1(h) + ATP --> AKT-1(h){pT308} + ADP (phosphorylation) | AKT-1(h) + ATP --> AKT-1(h){p} + ADP (phosphorylation) | AKT-1(h) + ATP --> AKT-1(h){pS473} + ADP (phosphorylation; automodification) | AKT-1(h) --> AKT-1(h) (translocation) | AKT-1(h) + 2 ATP --> AKT-1(h){pT308}{pS473} + 2 ADP (phosphorylation) | AKT-1(h) + ATP --MAPKAPK2(m.s.)--> AKT-1(h){pS473} + ADP (phosphorylation) | AKT-1(h) + JIP1(h) <==> AKT-1(h):JIP1(h) (binding) | AKT-1(h) + MKK4(h) <==> AKT-1(h):MKK4(h) (binding) | MST1(h) + AKT-1(h) <==> MST1(h):AKT-1(h) (binding) | MST1(m.s.) + AKT-1(h) <==> MST1(m.s.):AKT-1(h) (binding) | AKT-1(h) --> Skp2(h) (increase of abundance) | AKT-1(h) --/ p27Kip1(h) (decrease of abundance) | AKT-1(h) --> SKP2(h) (transactivation) | AKT-1(h) + Skp2(m.s.) <==> Skp2(m.s.):AKT-1(h) (binding) | AKT-1(h) + Skp2(h) <==> AKT-1(h):Skp2(h) (binding) | AKT1(h) --> AKT-1(h) (expression). | caveolin-1(m.s.) --> AKT-1(h) (activation) | AKT-1(h) --> AKT-1(h) (translocation) | CHIP(h) --/ AKT-1(h) (decrease of abundance) | FOXO3a(h) + ATP --AKT-1(h)--> FOXO3a(h){pS294}{pS344}{pS425} + ADP (phosphorylation) | FOXO1A(h) + ATP --AKT-1(h)--> FOXO1A(h){p} + ADP (phosphorylation) | p300(h) + ATP --AKT-1(h)--> p300(h){p} + ADP (phosphorylation) | tuberin(h) + NTP --AKT-1(h)--> tuberin(h){p} + NDP (phosphorylation) | foxo4(h) + ATP --AKT-1(h)--> foxo4(h){pT28}{pS193}{pS258} + ADP (phosphorylation) | mdm2(h) + 2 ATP --AKT-1(h)--> mdm2(h){pS166}{pS188} + 2 ADP (phosphorylation) | AR-isoform1(h) + ATP --AKT-1(h)--> AR-isoform1(h){p} + ADP (phosphorylation) | MKK4(m.s.) + ATP --AKT-1(h)--> MKK4(m.s.){pS80} + ADP (phosphorylation) | ASK1(m.s.) + ATP --AKT-1(h)--> ASK1(m.s.){pS83} + ADP (phosphorylation) | bad(m.s.) + ATP --AKT-1(h)--> bad(m.s.){pS136} + ADP (phosphorylation) | Skp2(h) + ATP --AKT-1(h)--> Skp2(h){p} + ADP (phosphorylation) | Skp2(h) + ATP --AKT-1(h)--> Skp2(h){pS72} + ADP (phosphorylation) | GSK3beta(m.s.) + ATP --AKT-1(h)--> GSK3beta(m.s.){pS} + ADP (phosphorylation) | AKT-1(h) --/ p21Cip1(h) (decrease of abundance) | AKT-1(h) + calmodulin(b) <==> AKT-1(h):calmodulin(b) (binding) | AKT-1(h) + ATP --PDK1-isoform1(h)--> AKT-1(h){pT308} + ADP (phosphorylation) | AKT-1(h) + 2 ATP --PDK1-isoform1(h)--> AKT-1(h){pT308}{pS473} + 2 ADP (phosphorylation) | AKT-1(h) + Ft1(h) <==> AKT-1(h):Ft1(h) (binding) | AKT-1(h) --Caspase-3(h)--> AKT-1-p57(h) + protein remnants (cleavage) | AKT-1(h) --Caspase-3(h)--> AKT-1-p51(h) + protein remnants (cleavage) | AKT-1(h) --Caspase-3(h)--> AKT-1-p43(h) + protein remnants (cleavage) | AKT-1(h) --Caspase-3(h)--> AKT-1-p42(h) + protein remnants (cleavage) | AKT-1(h) --> AKT-1(h) (translocation) | AKT-1(h) + ATP --> AKT-1(h){pS473} + ADP (phosphorylation) | AKT-1(h) + ATP --mTOR(h):rictor(h):mLST8(h):SIN1(h)--> AKT-1(h){pS473} + ADP (phosphorylation) | AKT-1(h) + PEA-15(m.s.) <==> AKT-1(h):PEA-15(m.s.) (binding) | eNOS(b) + Hsp90(b) + AKT-1(h) + calmodulin(c) <==> eNOS(b):Hsp90(b):AKT-1(h):calmodulin(c) (binding) | Hsp90(b) + AKT-1(h) + calmodulin(c) + eNOS(b){pS1179} <==> Hsp90(b):AKT-1(h):calmodulin(c):eNOS(b){pS1179} (binding) | AKT-1(h) + Hsp90(b) + eNOS(b) <==> AKT-1(h):Hsp90(b):eNOS(b) (binding) | AKT-1(h) + Hsp90(b) <==> AKT-1(h):Hsp90(b) (binding) | AKT-1(h) + PKCepsilon(h) <==> AKT-1(h):PKCepsilon(h) (binding) | AKT-1(h) + eNOS(b) + PKCepsilon(h) <==> AKT-1(h):eNOS(b):PKCepsilon(h) (binding) | AKT-1(h) + 2 ATP --PKCepsilon(m)--> AKT-1(h){pT308}{pS473} + 2 ADP (phosphorylation) | Skp2(m.s.) + AKT-1(h) <==> Skp2(m.s.):AKT-1(h) (binding) | AKT-1(h) --> 14-3-3beta(m.s.):Skp2(m.s.) (increase of binding) | AKT1(h) --> AKT-1(h) (expression). | AKT-1(h) --> AKT-1(h) (translocation) | AR-isoform1(h) + ATP --AKT-1(h)--> AR-isoform1(h){pS213}{pS791} + ADP (phosphorylation) | HCV-NS5A(HCV) + ATP --AKT-1(h)--> HCV-NS5A(HCV){p} + ADP (phosphorylation) | ER-beta(m) + ATP --AKT-1(h)--> ER-beta(m){pS} + ADP (phosphorylation) | ERR1(h) + ATP --AKT-1(h)--> ERR1(h){p} + ADP (phosphorylation) | FOXO1A(h) + 3 ATP --AKT-1(h)--> FOXO1A(h){pT24}{pS256}{pS319} + 3 ADP (phosphorylation) | MST1(m.s.) + ATP --AKT-1(h)--> MST1(m.s.){pT387} + ADP (phosphorylation) | mdm2-isoform1(h) + 2 ATP --AKT-1(h)--> mdm2-isoform1(h){pS166}{pS188} + 2 ADP (phosphorylation) | Nedd4-2(m.s.) + ATP --AKT-1(h)--> Nedd4-2(m.s.){p} + ADP (phosphorylation) | eNOS(b) + ATP --AKT-1(h)--> eNOS(b){pS1179} + ADP (phosphorylation) | GSK3beta(m.s.) + ATP --AKT-1(h)--> GSK3beta(m.s.){pS} + ADP (phosphorylation) | Skp2(m.s.) + ATP --AKT-1(h)--> Skp2(m.s.){pS72} + ADP (phosphorylation) | Skp2(h) + ATP --AKT-1(h)--> Skp2(h){pT21} + ADP (phosphorylation) | Skp2(m) + ATP --AKT-1(h)--> Skp2(m){p} + ADP (phosphorylation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
124 | Phosphoserine. | Swiss-Prot 53.0 | 126 | Phosphoserine. | Swiss-Prot 53.0 | 129 | Phosphoserine. | Swiss-Prot 53.0 | 308 | Phosphothreonine (by PDPK1). | Swiss-Prot 53.0 | 473 | Phosphoserine. | Swiss-Prot 53.0 | 474 | Phosphotyrosine. | Swiss-Prot 53.0 | 473 | Phosphoserine (ILK;PDK-1) | 11313365;10226025 | Phospho.ELM 6.0 | 308 | Phosphothreonine (PDK-1) | 9868760 | Phospho.ELM 6.0 | 474 | Phosphotyrosine | 12149249 | Phospho.ELM 6.0 | 124 | Phosphoserine | 12149249 | Phospho.ELM 6.0 | 450 | Phosphothreonine | 12149249 | Phospho.ELM 6.0 | 129 | Phosphoserine (CK2 alpha) | 15818404 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr14 |
Promoter: 104332625 - 104334625 | Agilent_014791 |
chr14 |
Promoter: 104330483 - 104332483 | Agilent_014791 |
chr14 |
Promoter: 104332625 - 104334625 | GoldenGate_Methylation_Cancer_Panel_I |
chr14 |
Promoter: 104332625 - 104334625 | GoldenGate_Methylation_Cancer_Panel_I |
chr14 |
Promoter: 104330483 - 104332483 | GSE27584 |
chr14 |
Promoter: 104332625 - 104334625 | GSE27584 |
chr14 |
Promoter: 104332625 - 104334625 | GSE27584 |
chr14 |
Promoter: 104332625 - 104334625 | Agilent_014791_44K |
chr14 |
Promoter: 104332625 - 104334625 | Agilent_014791_44K |
chr14 |
Promoter: 104332625 - 104334625 | Agilent_014791 |
chr14 |
Promoter: 104330483 - 104332483 | Agilent_014791 |