| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 22926 |
Name | ATF6 |
Synonym | ATF6A;activating transcription factor 6;ATF6;activating transcription factor 6 |
Definition | cAMP-dependent transcription factor ATF-6 alpha|cyclic AMP-dependent transcription factor ATF-6 alpha |
Position | 1q22-q23 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "Several ER stress/UPR genes, including Immunoglobulin-heavy-chain binding protein (BiP), Activating Transcription Factor-4 and -6 (ATF4 and ATF6) and a spliced form of X-box binding protein (XBP1) were upregulated in lcSSc PBMCs, with the highest levels in patients with PAH. TG upregulated Heat shock proteins (HSP) and Interferon-regulated genes in control PBMCs. Selected HSP genes, particularly DNAJB1, and IFN-related genes were also found at significantly elevated levels in PBMCs from lcSSc patients, while IRF4 was significantly decreased. There was a positive correlation between DNAJB1 and severity of PAH disease (PAP) (r = 0.56, p<0.05) and between ER stress markers and IL-6 levels (r = 0.53, p< 0.0001) in lcSSc PBMCs." |
| More detail of all Human literatures about ATF6 | |
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Pathways and Diseases |
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Pathway | Activation of Chaperones by ATF6-alpha;PID Reactome;500130 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Signaling mediated by p38-alpha and p38-beta;PID Curated;200154 |
Pathway | Alzheimer's disease;KEGG PATHWAY;hsa05010 |
Pathway | Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141 |
Disease | Parkinson's disease (age of onset);GAD |
Disease | Cardiovascular Diseases;GAD |
Disease | diabetes, type 2 glucose tolerance;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | diabetes, type 2;GAD |
Disease | METABOLIC;GAD |
Disease | Parkinson's disease (age of onset);NHGRI |
Disease | NEUROLOGICAL;GAD |
Disease | Hyperlipidemia, Familial Combined;GAD |
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External Links |
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Links to Entrez Gene | 22926 |
Links to all GeneRIF Items | 22926 |
Links to iHOP | 22926 |
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Sequence Information |
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Nucleotide Sequence |
>22926 : length: 2013 atgggggagccggctggggttgccggcaccatggagtcaccttttagcccgggactcttt cacaggctggatgaagattgggattctgctctctttgctgaactcggttatttcacagac actgatgagctgcaattggaagcagcaaatgagacgtatgaaaacaattttgataatctt gattttgatttggatttgatgccttgggagtcagacatttgggacatcaacaaccaaatc tgtacagttaaagatattaaggcagaacctcagccactttctccagcctcctcaagttat tcagtctcgtctcctcggtcagtggactcttattcttcaactcagcatgttcctgaggag ttggatttgtcttctagttctcagatgtctcccctttccttatatggtgaaaactctaat agtctctcttcagcggagccactgaaggaagataagcctgtcactggtcctaggaacaag actgaaaatggactgactccaaagaaaaaaattcaggtgaattcaaaaccttcaattcag cccaagcctttattgcttccagcagcacccaagactcaaacaaactccagtgttccagca aaaaccatcattattcagacagtaccaacgcttatgccattggcaaagcagcaaccaatt atcagtttacaacctgcacccactaaaggccagacggttttgctgtctcagcctactgtg gtacaacttcaagcacctggagttctgccctctgctcagccagtccttgctgttgctggg ggagtcacacagctccctaatcacgtggtgaatgtggtaccagccccttcagcgaatagc ccagtgaatggaaaactttccgtgactaaacctgtcctacaaagtaccatgagaaatgtc ggttcagatattgctgtgctaaggagacagcaacgtatgataaaaaatcgagaatccgct tgtcagtctcgcaagaagaagaaagaatatatgctagggttagaggcgagattaaaggct gccctctcagaaaacgagcaactgaagaaagaaaatggaacactgaagcggcagctggat gaagttgtgtcagagaaccagaggcttaaagtccctagtccaaagcgaagagttgtctgt gtgatgatagtattggcatttataatactgaactatggacctatgagcatgttggaacag gattccaggagaatgaaccctagtgtgagccctgcaaatcaaaggaggcaccttctagga ttttctgctaaagaggcacaggacacatcagatggtattatccagaaaaacagctacaga tatgatcattctgtttcaaatgacaaagccctgatggtgctaactgaagaaccattgctt tacattcctccacctccttgtcagcccctaattaacacaacagagtctctcaggttaaat catgaacttcgaggatgggttcatagacatgaagtagaaaggaccaagtcaagaagaatg acaaataatcaacagaaaacccgtattcttcagggtgctctggaacagggctcaaattct cagctgatggctgttcaatacacagaaaccactagtagtatcagcaggaactcagggagt gagctacaagtgtattatgcttcacccagaagttatcaagacttttttgaagccatccgc agaaggggagacacattttatgttgtgtcatttcgaagggatcacctgctgttaccagct accacccataacaagaccacaagaccaaaaatgtcaattgtgttaccagcaataaacata aatgagaatgtgatcaatgggcaggactacgaagtgatgatgcagattgactgtcaggtg atggacaccaggatcctccatatcaaaagttcgtcagttcctccttacctccgagatcag cagaggaatcaaaccaacaccttctttggctcccctcccgcagccacagaggcaacccac gttgtcagcaccatccctgagtcattacaatag |
Protein Sequence |
>22926 : length: 670 MGEPAGVAGTMESPFSPGLFHRLDEDWDSALFAELGYFTDTDELQLEAANETYENNFDNL DFDLDLMPWESDIWDINNQICTVKDIKAEPQPLSPASSSYSVSSPRSVDSYSSTQHVPEE LDLSSSSQMSPLSLYGENSNSLSSAEPLKEDKPVTGPRNKTENGLTPKKKIQVNSKPSIQ PKPLLLPAAPKTQTNSSVPAKTIIIQTVPTLMPLAKQQPIISLQPAPTKGQTVLLSQPTV VQLQAPGVLPSAQPVLAVAGGVTQLPNHVVNVVPAPSANSPVNGKLSVTKPVLQSTMRNV GSDIAVLRRQQRMIKNRESACQSRKKKKEYMLGLEARLKAALSENEQLKKENGTLKRQLD EVVSENQRLKVPSPKRRVVCVMIVLAFIILNYGPMSMLEQDSRRMNPSVSPANQRRHLLG FSAKEAQDTSDGIIQKNSYRYDHSVSNDKALMVLTEEPLLYIPPPPCQPLINTTESLRLN HELRGWVHRHEVERTKSRRMTNNQQKTRILQGALEQGSNSQLMAVQYTETTSSISRNSGS ELQVYYASPRSYQDFFEAIRRRGDTFYVVSFRRDHLLLPATTHNKTTRPKMSIVLPAINI NENVINGQDYEVMMQIDCQVMDTRILHIKSSSVPPYLRDQQRNQTNTFFGSPPAATEATH VVSTIPESLQ |