Entrez Gene

Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	22926
Name	ATF6
Synonymous	ATF6A;activating transcription factor 6;ATF6;activating transcription factor 6
Definition	cAMP-dependent transcription factor ATF-6 alpha\|cyclic AMP-dependent transcription factor ATF-6 alpha
Position	1q22-q23
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Link to UCSC genome	Matched SNP location	dbSNP ID	Regulatory information
ENCODE RegulomeDB [Top]
chr1:161736084-161933860	chr1:161746678-161746678	rs2340823	Single_Nucleotides\|eQTL\|ATF6, Chromatin_Structure\|FAIRE\|Gm12891, Chromatin_Structure\|DNase-seq\|Jurkat
chr1:161736084-161933860	chr1:161891556-161891556	rs6687226	Single_Nucleotides\|eQTL\|FCRLM2, Motifs\|PWM\|Vsx1, Motifs\|PWM\|Barx1, Motifs\|PWM\|Barx2, Motifs\|PWM\|En1, Motifs\|PWM\|Hoxb7, Motifs\|PWM\|Hoxc5, Motifs\|PWM\|Hoxc6, Motifs\|PWM\|Hoxd8, Motifs\|PWM\|Nkx6-1, Motifs\|PWM\|Nkx6-1, Motifs\|PWM\|Nkx6-3, Chromatin_Structure\|FAIRE\|Medullo, Chromatin_Structure\|DNase-seq\|Panc1, Chromatin_Structure\|FAIRE\|K562, Chromatin_Structure\|FAIRE\|K562
chr1:161736084-161933860	chr1:161899731-161899731	rs10918215	Single_Nucleotides\|eQTL\|FCRLM2, Single_Nucleotides\|eQTL\|NIT1, Motifs\|PWM\|SRF, Chromatin_Structure\|DNase-seq\|Hffmyc, Chromatin_Structure\|DNase-seq\|Hvmf
chr1:161736084-161933860	chr1:161903534-161903534	rs10733044	Single_Nucleotides\|eQTL\|FCGR2B, Single_Nucleotides\|eQTL\|FCRLM2, Motifs\|PWM\|FOXM1, Chromatin_Structure\|FAIRE\|Gm18507, Chromatin_Structure\|DNase-seq\|Gm19240, Chromatin_Structure\|DNase-seq\|Be2c, Chromatin_Structure\|FAIRE\|Gm12891, Protein_Binding\|ChIP-seq\|EP300, Protein_Binding\|ChIP-seq\|SPI1
chr1:161736084-161933860	chr1:161903683-161903683	rs4570397	Single_Nucleotides\|eQTL\|NIT1, Single_Nucleotides\|eQTL\|FCRLM2, Chromatin_Structure\|FAIRE\|Gm12891, Chromatin_Structure\|DNase-seq\|Sknmc, Chromatin_Structure\|FAIRE\|Gm19239, Protein_Binding\|ChIP-seq\|SPI1
chr1:161736084-161933860	chr1:161906670-161906670	rs10753686	Single_Nucleotides\|eQTL\|NIT1, Single_Nucleotides\|eQTL\|FCRLM2, Chromatin_Structure\|DNase-seq\|Phte, Chromatin_Structure\|DNase-seq\|Hee, Chromatin_Structure\|DNase-seq\|Saec
chr1:161736084-161933860	chr1:161909599-161909599	rs4657124	Single_Nucleotides\|eQTL\|NIT1, Single_Nucleotides\|eQTL\|FCRLM2, Motifs\|PWM\|SREBP-1, Motifs\|PWM\|TFE, Motifs\|PWM\|CDP, Motifs\|PWM\|Cutl1, Chromatin_Structure\|DNase-seq\|Hcfaa, Chromatin_Structure\|FAIRE\|Gm12892, Chromatin_Structure\|FAIRE\|Huvec
chr1:161736084-161933860	chr1:161915387-161915387	rs4656339	Single_Nucleotides\|eQTL\|FCGR2B, Single_Nucleotides\|eQTL\|FCRLM2, Motifs\|PWM\|Tal1::Gata1, Chromatin_Structure\|DNase-seq\|K562, Protein_Binding\|ChIP-seq\|GATA1, Protein_Binding\|ChIP-seq\|GATA1, Protein_Binding\|ChIP-seq\|MAFK, Protein_Binding\|ChIP-seq\|TAL1, Protein_Binding\|ChIP-seq\|CCNT2, Protein_Binding\|ChIP-seq\|GATA1, Protein_Binding\|ChIP-seq\|GATA1, Protein_Binding\|ChIP-seq\|TAL1
chr1:161736084-161933860	chr1:161931167-161931167	rs2499852	Single_Nucleotides\|eQTL\|FCRLM2, Motifs\|PWM\|C/EBPgamma, Chromatin_Structure\|DNase-seq\|Fibrobl

Regulation From TransFac database
Transcription Factors [Top]
ATF6(h) --> HSPA5(h) (DNA binding).
ATF6(h) --> ATF6(h) (expression).
2 ATF6(h) <==> (ATF6(h))2 (oligomerization)
ATF6(h) + XBP-1U(h) <==> ATF6(h):XBP-1U(h) (binding)
ATF6(h) + Zhangfei(h) <==> ATF6(h):Zhangfei(h) (binding)
ATF6(h) --> ATF6-p65(h) + protein remnants (cleavage).
ATF6(h) --> ATF6(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
472	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
584	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
643	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0

Chromosome	Location	Source
Methylation Profile [Top]
chr1	Promoter: 160001208 - 160003208	GSE27584
chr1	Promoter: 160001208 - 160003208	E-GEOD-20553

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