| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 2335 |
Name | FN1 |
Synonym | CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF;fibronectin 1;FN1;fibronectin 1 |
Definition | cold-insoluble globulin|fibronectin|migration-stimulating factor |
Position | 2q34 |
Gene Type | protein-coding |
|
PAH Type |
Description |
PH | study concludes that increased serotonylation of fibronectin occurs in pulmonary hypertension. |
| More detail of all Human literatures about FN1 | |
|
Pathways and Diseases |
|
Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Syndecan-4-mediated signaling events;PID Curated;200115 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Cell surface interactions at the vascular wall;PID Reactome;500305 |
Pathway | Angiopoietin receptor Tie2-mediated signaling;PID Curated;200066 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | VEGFR3 signaling in lymphatic endothelium;PID Curated;200188 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | Integrin cell surface interactions;PID Reactome;500004 |
Pathway | ECM-receptor interaction;KEGG PATHWAY;hsa04512 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Syndecan-2-mediated signaling events;PID Curated;200164 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Disease | HEMATOLOGICAL;GAD |
Disease | lymphoma;GAD |
Disease | systemic sclerosis;GAD |
Disease | Glomerulopathy with fibronectin deposits 2;OMIM |
Disease | Cryoglobulinemia;GAD |
Disease | Nephrolithiasis;GAD |
Disease | RENAL;GAD |
|
External Links |
|
Links to Entrez Gene | 2335 |
Links to all GeneRIF Items | 2335 |
Links to iHOP | 2335 |
|
Sequence Information |
|
Nucleotide Sequence |
>2335 : length: 7068 atgcttaggggtccggggcccgggctgctgctgctggccgtccagtgcctggggacagcg gtgccctccacgggagcctcgaagagcaagaggcaggctcagcaaatggttcagccccag tccccggtggctgtcagtcaaagcaagcccggttgttatgacaatggaaaacactatcag ataaatcaacagtgggagcggacctacctaggcaatgcgttggtttgtacttgttatgga ggaagccgaggttttaactgcgagagtaaacctgaagctgaagagacttgctttgacaag tacactgggaacacttaccgagtgggtgacacttatgagcgtcctaaagactccatgatc tgggactgtacctgcatcggggctgggcgagggagaataagctgtaccatcgcaaaccgc tgccatgaagggggtcagtcctacaagattggtgacacctggaggagaccacatgagact ggtggttacatgttagagtgtgtgtgtcttggtaatggaaaaggagaatggacctgcaag cccatagctgagaagtgttttgatcatgctgctgggacttcctatgtggtcggagaaacg tgggagaagccctaccaaggctggatgatggtagattgtacttgcctgggagaaggcagc ggacgcatcacttgcacttctagaaatagatgcaacgatcaggacacaaggacatcctat agaattggagacacctggagcaagaaggataatcgaggaaacctgctccagtgcatctgc acaggcaacggccgaggagagtggaagtgtgagaggcacacctctgtgcagaccacatcg agcggatctggccccttcaccgatgttcgtgcagctgtttaccaaccgcagcctcacccc cagcctcctccctatggccactgtgtcacagacagtggtgtggtctactctgtggggatg cagtggctgaagacacaaggaaataagcaaatgctttgcacgtgcctgggcaacggagtc agctgccaagagacagctgtaacccagacttacggtggcaactcaaatggagagccatgt gtcttaccattcacctacaatggcaggacgttctactcctgcaccacagaagggcgacag gacggacatctttggtgcagcacaacttcgaattatgagcaggaccagaaatactctttc tgcacagaccacactgttttggttcagactcgaggaggaaattccaatggtgccttgtgc cacttccccttcctatacaacaaccacaattacactgattgcacttctgagggcagaaga gacaacatgaagtggtgtgggaccacacagaactatgatgccgaccagaagtttgggttc tgccccatggctgcccacgaggaaatctgcacaaccaatgaaggggtcatgtaccgcatt ggagatcagtgggataagcagcatgacatgggtcacatgatgaggtgcacgtgtgttggg aatggtcgtggggaatggacatgcattgcctactcgcagcttcgagatcagtgcattgtt gatgacatcacttacaatgtgaacgacacattccacaagcgtcatgaagaggggcacatg ctgaactgtacatgcttcggtcagggtcggggcaggtggaagtgtgatcccgtcgaccaa tgccaggattcagagactgggacgttttatcaaattggagattcatgggagaagtatgtg catggtgtcagataccagtgctactgctatggccgtggcattggggagtggcattgccaa cctttacagacctatccaagctcaagtggtcctgtcgaagtatttatcactgagactccg agtcagcccaactcccaccccatccagtggaatgcaccacagccatctcacatttccaag tacattctcaggtggagacctaaaaattctgtaggccgttggaaggaagctaccatacca ggccacttaaactcctacaccatcaaaggcctgaagcctggtgtggtatacgagggccag ctcatcagcatccagcagtacggccaccaagaagtgactcgctttgacttcaccaccacc agcaccagcacacctgtgaccagcaacaccgtgacaggagagacgactcccttttctcct cttgtggccacttctgaatctgtgaccgaaatcacagccagtagctttgtggtctcctgg gtctcagcttccgacaccgtgtcgggattccgggtggaatatgagctgagtgaggaggga gatgagccacagtacctggatcttccaagcacagccacttctgtgaacatccctgacctg cttcctggccgaaaatacattgtaaatgtctatcagatatctgaggatggggagcagagt ttgatcctgtctacttcacaaacaacagcgcctgatgcccctcctgacccgactgtggac caagttgatgacacctcaattgttgttcgctggagcagaccccaggctcccatcacaggg tacagaatagtctattcgccatcagtagaaggtagcagcacagaactcaaccttcctgaa actgcaaactccgtcaccctcagtgacttgcaacctggtgttcagtataacatcactatc tatgctgtggaagaaaatcaagaaagtacacctgttgtcattcaacaagaaaccactggc accccacgctcagatacagtgccctctcccagggacctgcagtttgtggaagtgacagac gtgaaggtcaccatcatgtggacaccgcctgagagtgcagtgaccggctaccgtgtggat gtgatccccgtcaacctgcctggcgagcacgggcagaggctgcccatcagcaggaacacc tttgcagaagtcaccgggctgtcccctggggtcacctattacttcaaagtctttgcagtg agccatgggagggagagcaagcctctgactgctcaacagacaaccaaactggatgctccc actaacctccagtttgtcaatgaaactgattctactgtcctggtgagatggactccacct cgggcccagataacaggataccgactgaccgtgggccttacccgaagaggacagcccagg cagtacaatgtgggtccctctgtctccaagtacccactgaggaatctgcagcctgcatct gagtacaccgtatccctcgtggccataaagggcaaccaagagagccccaaagccactgga gtctttaccacactgcagcctgggagctctattccaccttacaacaccgaggtgactgag accaccattgtgatcacatggacgcctgctccaagaattggttttaagctgggtgtacga ccaagccagggaggagaggcaccacgagaagtgacttcagactcaggaagcatcgttgtg tccggcttgactccaggagtagaatacgtctacaccatccaagtcctgagagatggacag gaaagagatgcgccaattgtaaacaaagtggtgacaccattgtctccaccaacaaacttg catctggaggcaaaccctgacactggagtgctcacagtctcctgggagaggagcaccacc ccagacattactggttatagaattaccacaacccctacaaacggccagcagggaaattct ttggaagaagtggtccatgctgatcagagctcctgcacttttgataacctgagtcccggc ctggagtacaatgtcagtgtttacactgtcaaggatgacaaggaaagtgtccctatctct gataccatcatcccagctgttcctcctcccactgacctgcgattcaccaacattggtcca gacaccatgcgtgtcacctgggctccacccccatccattgatttaaccaacttcctggtg cgttactcacctgtgaaaaatgaggaagatgttgcagagttgtcaatttctccttcagac aatgcagtggtcttaacaaatctcctgcctggtacagaatatgtagtgagtgtctccagt gtctacgaacaacatgagagcacacctcttagaggaagacagaaaacaggtcttgattcc ccaactggcattgacttttctgatattactgccaactcttttactgtgcactggattgct cctcgagccaccatcactggctacaggatccgccatcatcccgagcacttcagtgggaga cctcgagaagatcgggtgccccactctcggaattccatcaccctcaccaacctcactcca ggcacagagtatgtggtcagcatcgttgctcttaatggcagagaggaaagtcccttattg attggccaacaatcaacagtttctgatgttccgagggacctggaagttgttgctgcgacc cccaccagcctactgatcagctgggatgctcctgctgtcacagtgagatattacaggatc acttacggagagacaggaggaaatagccctgtccaggagttcactgtgcctgggagcaag tctacagctaccatcagcggccttaaacctggagttgattataccatcactgtgtatgct gtcactggccgtggagacagccccgcaagcagcaagccaatttccattaattaccgaaca gaaattgacaaaccatcccagatgcaagtgaccgatgttcaggacaacagcattagtgtc aagtggctgccttcaagttcccctgttactggttacagagtaaccaccactcccaaaaat ggaccaggaccaacaaaaactaaaactgcaggtccagatcaaacagaaatgactattgaa ggcttgcagcccacagtggagtatgtggttagtgtctatgctcagaatccaagcggagag agtcagcctctggttcagactgcagtaaccaacattgatcgccctaaaggactggcattc actgatgtggatgtcgattccatcaaaattgcttgggaaagcccacaggggcaagtttcc aggtacagggtgacctactcgagccctgaggatggaatccatgagctattccctgcacct gatggtgaagaagacactgcagagctgcaaggcctcagaccgggttctgagtacacagtc agtgtggttgccttgcacgatgatatggagagccagcccctgattggaacccagtccaca gctattcctgcaccaactgacctgaagttcactcaggtcacacccacaagcctgagcgcc cagtggacaccacccaatgttcagctcactggatatcgagtgcgggtgacccccaaggag aagaccggaccaatgaaagaaatcaaccttgctcctgacagctcatccgtggttgtatca ggacttatggtggccaccaaatatgaagtgagtgtctatgctcttaaggacactttgaca agcagaccagctcagggagttgtcaccactctggagaatgtcagcccaccaagaagggct cgtgtgacagatgctactgagaccaccatcaccattagctggagaaccaagactgagacg atcactggcttccaagttgatgccgttccagccaatggccagactccaatccagagaacc atcaagccagatgtcagaagctacaccatcacaggtttacaaccaggcactgactacaag atctacctgtacaccttgaatgacaatgctcggagctcccctgtggtcatcgacgcctcc actgccattgatgcaccatccaacctgcgtttcctggccaccacacccaattccttgctg gtatcatggcagccgccacgtgccaggattaccggctacatcatcaagtatgagaagcct gggtctcctcccagagaagtggtccctcggccccgccctggtgtcacagaggctactatt actggcctggaaccgggaaccgaatatacaatttatgtcattgccctgaagaataatcag aagagcgagcccctgattggaaggaaaaagacagacgagcttccccaactggtaaccctt ccacaccccaatcttcatggaccagagatcttggatgttccttccacagttcaaaagacc cctttcgtcacccaccctgggtatgacactggaaatggtattcagcttcctggcacttct ggtcagcaacccagtgttgggcaacaaatgatctttgaggaacatggttttaggcggacc acaccgcccacaacggccacccccataaggcataggccaagaccatacccgccgaatgta ggacaagaagctctctctcagacaaccatctcatgggccccattccaggacacttctgag tacatcatttcatgtcatcctgttggcactgatgaagaacccttacagttcagggttcct ggaacttctaccagtgccactctgacaggcctcaccagaggtgccacctacaacatcata gtggaggcactgaaagaccagcagaggcataaggttcgggaagaggttgttaccgtgggc aactctgtcaacgaaggcttgaaccaacctacggatgactcgtgctttgacccctacaca gtttcccattatgccgttggagatgagtgggaacgaatgtctgaatcaggctttaaactg ttgtgccagtgcttaggctttggaagtggtcatttcagatgtgattcatctagatggtgc catgacaatggtgtgaactacaagattggagagaagtgggaccgtcagggagaaaatggc cagatgatgagctgcacatgtcttgggaacggaaaaggagaattcaagtgtgaccctcat gaggcaacgtgttatgatgatgggaagacataccacgtaggagaacagtggcagaaggaa tatctcggtgccatttgctcctgcacatgctttggaggccagcggggctggcgctgtgac aactgccgcagacctgggggtgaacccagtcccgaaggcactactggccagtcctacaac cagtattctcagagataccatcagagaacaaacactaatgttaattgcccaattgagtgc ttcatgcctttagatgtacaggctgacagagaagattcccgagagtaa |
Protein Sequence |
>2335 : length: 2355 MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQ INQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMI WDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCK PIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSY RIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHP QPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALC HFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRI GDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHM LNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQ PLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIP GHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSP LVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDL LPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITG YRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTG TPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNT FAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPP RAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATG VFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVV SGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTT PDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPIS DTIIPAVPPPTDLRFTNIGPDTMRVTWAPPPSIDLTNFLVRYSPVKNEEDVAELSISPSD NAVVLTNLLPGTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIA PRATITGYRIRHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLL IGQQSTVSDVPRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSK STATISGLKPGVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISV KWLPSSSPVTGYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGE SQPLVQTAVTNIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAP DGEEDTAELQGLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSA QWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLT SRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANGQTPIQRT IKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDASTAIDAPSNLRFLATTPNSLL VSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ KSEPLIGRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTS GQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGQEALSQTTISWAPFQDTSE YIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNIIVEALKDQQRHKVREEVVTVG NSVNEGLNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRCDSSRWC HDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQKE YLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRTNTNVNCPIEC FMPLDVQADREDSRE |