| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 2335 |
Name | FN1 |
Synonymous | CIG|ED-B|FINC|FN|FNZ|GFND|GFND2|LETS|MSF;fibronectin 1;FN1;fibronectin 1 |
Definition | cold-insoluble globulin|fibronectin|migration-stimulating factor |
Position | 2q34 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr2:216225163-216300895 | chr2:216229692-216229692 | rs11651 | Single_Nucleotides|eQTL|ATIC, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|FAIRE|Gm12892, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|FAIRE|Nhbe, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A | chr2:216225163-216300895 | chr2:216230081-216230081 | rs7594168 | Single_Nucleotides|eQTL|ATIC, Motifs|Footprinting|Lyf-1, Motifs|PWM|Lyf-1, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|FAIRE|Gm12878, Chromatin_Structure|FAIRE|Gm12891, Chromatin_Structure|FAIRE|Gm18507, Protein_Binding|ChIP-seq|EP300 | chr2:216225163-216300895 | chr2:216232556-216232556 | rs7568287 | Single_Nucleotides|eQTL|ATIC, Motifs|PWM|Ehf, Motifs|PWM|Elf3, Chromatin_Structure|FAIRE|Astrocy, Chromatin_Structure|DNase-seq|Progfib, Chromatin_Structure|DNase-seq|Myometr, Chromatin_Structure|FAIRE|Gliobla, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Hct116, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|Nhdfneo, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Hconf, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|DNase-seq|Hee, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Hac, Chromatin_Structure|DNase-seq|Skmc, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|DNase-seq|Hmvecdblad, Chromatin_Structure|DNase-seq|Ag10803, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Nha, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Hpf, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Nhlf, Chromatin_Structure|DNase-seq|Nhdfad, Chromatin_Structure|DNase-seq|Hrgec, Chromatin_Structure|DNase-seq|Hpdlf, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Aoaf, Chromatin_Structure|DNase-seq|Ag09319, Chromatin_Structure|DNase-seq|Hffmyc, Chromatin_Structure|DNase-seq|Rptec, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|FAIRE|Nhbe, Protein_Binding|ChIP-seq|FOS, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A | chr2:216225163-216300895 | chr2:216233698-216233698 | rs1250211 | Single_Nucleotides|eQTL|ATIC, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|FAIRE|Astrocy | chr2:216225163-216300895 | chr2:216282481-216282481 | rs724617 | Single_Nucleotides|eQTL|ATIC, Motifs|PWM|PPARalpha:RXRalpha, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Rptec, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|Sknmc, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Hac, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Huh7, Chromatin_Structure|DNase-seq|Hmf, Protein_Binding|ChIP-seq|NR3C1, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|TBP, Protein_Binding|ChIP-seq|GATA2, Protein_Binding|ChIP-seq|NR3C1, Protein_Binding|ChIP-seq|TCF4, Protein_Binding|ChIP-seq|CDX2, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|EP300, Protein_Binding|ChIP-seq|AR, Protein_Binding|ChIP-seq|GATA6 | chr2:216225163-216300895 | chr2:216282974-216282974 | rs10199059 | Single_Nucleotides|eQTL|ATIC, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|FAIRE|Mcf7, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|FAIRE|Astrocy, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A | chr2:216225163-216300895 | chr2:216299281-216299281 | rs1250246 | Single_Nucleotides|eQTL|ATIC, Motifs|Footprinting|AIRE, Motifs|PWM|AIRE, Chromatin_Structure|DNase-seq|Hepatocytes, Protein_Binding|ChIP-seq|POLR2A | chr2:216225163-216300895 | chr2:216300185-216300185 | rs1250258 | Single_Nucleotides|eQTL|ATIC, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|DNase-seq|Melano, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Wi38, Protein_Binding|ChIP-seq|HEY1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|SIN3A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A |
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Transcription Factors [Top] |
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Regulation From TransFac database |
LTBP1(h) + fibronectin(h) --TGC(gp)--> LTBP1(h):fibronectin(h) (oligomerization) | TGFbeta1(h):LAP(h):LTBP1(h) + fibronectin(h) --TGC(gp)--> TGFbeta1(h):LAP(h):LTBP1(h):fibronectin(h) (binding; assembly) | fibronectin(h) + CD11B(m.s.):beta2-integrin(h) <==> fibronectin(h):CD11B(m.s.):beta2-integrin(h) (binding) | CD11D(h):beta2-integrin(h) + fibronectin(h) <==> CD11D(h):beta2-integrin(h):fibronectin(h) (binding) | fibronectin(h) + CD11B(m) <==> fibronectin(h):CD11B(m) (binding) | fibronectin(h) + CD11D(m) <==> fibronectin(h):CD11D(m) (binding) | fibronectin(h) + CD11D(h) <==> fibronectin(h):CD11D(h) (binding) | fibronectin(h) --> FAK(h){p} (increase of phosphorylation) | fibronectin(h) --> p110alpha(h){pY} (increase of phosphorylation) | fibronectin(h) --> ERK1(h){p} (increase of phosphorylation) | fibronectin(h) --> ERK2(h){p} (increase of phosphorylation) | fibronectin(h) --> mmp2(h) (increase of abundance) | fibronectin(h) --> MT1-MMP(h) (increase of abundance) | fibronectin(h) + Keratin-19(h) <==> fibronectin(h):Keratin-19(h) (binding) | FN1(h) --> fibronectin(h) (expression). | TGFbeta2(h) --> fibronectin(h) (increase of abundance) | Dab2(h) --> fibronectin(h) (increase of abundance) | Dab2(m) --> fibronectin(h) (increase of abundance) | TGFbeta1(h) --> fibronectin(h) (increase of abundance) | EGF(m.s.) --> fibronectin(h) (increase of abundance) | FN1(h) --> fibronectin-xbb13(h) (expression). | FN1(h) --> fibronectin-1(h) (expression). | FN1(h) --> fibronectin-2(h) (expression). | FN1(h) --> fibronectin-3(h) (expression). | FN1(h) --> fibronectin-4(h) (expression). | FN1(h) --> fibronectin-5(h) (expression). | FN1(h) --> fibronectin-6(h) (expression). | FN1(h) --> fibronectin-7(h) (expression). | FN1(h) --> fibronectin-8(h) (expression). | FN1(h) --> fibronectin-9(h) (expression). | FN1(h) --> fibronectin-10(h) (expression). | FN1(h) --> fibronectin-11(h) (expression). | FN1(h) --> fibronectin-12(h) (expression). | FN1(h) --> fibronectin(h) (expression). | hsa-miR-199a* --/ fibronectin(h) (translational repression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
32 | Pyrrolidone carboxylic acid. | Swiss-Prot 53.0 | 430 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 528 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 542 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 876 | Sulfotyrosine (Potential). | Swiss-Prot 53.0 | 877 | N-linked (GlcNAc...) (By similarity). | Swiss-Prot 53.0 | 881 | Sulfotyrosine (Potential). | Swiss-Prot 53.0 | 1007 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 1244 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 2064 | O-linked (GalNAc...). | Swiss-Prot 53.0 | 2065 | O-linked (GalNAc...) (By similarity). | Swiss-Prot 53.0 | 2108 | N-linked (GlcNAc...) (By similarity). | Swiss-Prot 53.0 | 2384 | Phosphoserine. | Swiss-Prot 53.0 | 34 | Isoglutamyl lysine isopeptide (Gln-Lys)(interchain with K-?) (Probable). | Swiss-Prot 53.0 | 63 | Isoglutamyl lysine isopeptide (Gln-Lys)(interchain with K-?) (Probable). | Swiss-Prot 53.0 | 1443 | Isoglutamyl lysine isopeptide (Gln-Lys)(interchain with K-?) (Probable). | Swiss-Prot 53.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr2 |
Promoter: 216008536 - 216010536 | Agilent_014791 |
chr2 |
Promoter: 216008536 - 216010536 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 216008536 - 216010536 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 216008536 - 216010536 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 216008536 - 216010536 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 216008536 - 216010536 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 216008536 - 216010536 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 216008536 - 216010536 | GoldenGate_Methylation_Cancer_Panel_I |
chr2 |
Promoter: 216008536 - 216010536 | GSE27584 |
chr2 |
Promoter: 216008536 - 216010536 | GSE27584 |
chr2 |
Promoter: 216008536 - 216010536 | GSE27584 |
chr2 |
Promoter: 216008536 - 216010536 | GSE27584 |
chr2 |
Promoter: 216008536 - 216010536 | GSE27584 |
chr2 |
Promoter: 216008536 - 216010536 | GSE27584 |
chr2 |
Promoter: 216008536 - 216010536 | GSE27584 |
chr2 |
Promoter: 216008536 - 216010536 | Agilent_014791_44K |
chr2 |
Promoter: 216008536 - 216010536 | Agilent_014791_44K |
chr2 |
Promoter: 216008536 - 216010536 | Agilent_014791_44K |
chr2 |
Promoter: 216008536 - 216010536 | Agilent_014791_44K |
chr2 |
Promoter: 216008536 - 216010536 | Agilent_014791_44K |
chr2 |
Promoter: 216008536 - 216010536 | Agilent_014791_44K |
chr2 |
Promoter: 216008536 - 216010536 | Agilent_014791_44K |
chr2 |
Promoter: 216008536 - 216010536 | PMID:15911243 |
chr2 |
Promoter: 216008536 - 216010536 | PMID:15911243 |
chr2 |
Promoter: 216008536 - 216010536 | PMID:15911243 |
chr2 |
Promoter: 216008536 - 216010536 | PMID:15911243 |
chr2 |
Promoter: 216008536 - 216010536 | PMID:15911243 |
chr2 |
Promoter: 216008536 - 216010536 | PMID:15911243 |
chr2 |
Promoter: 216008536 - 216010536 | PMID:15911243 |