| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3309 |
Name | HSPA5 |
Synonym | BIP|GRP78|MIF2;heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa);HSPA5;heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
Definition | 78 kDa glucose-regulated protein|endoplasmic reticulum lumenal Ca(2+)-binding protein grp78|immunoglobulin heavy chain-binding protein |
Position | 9q33.3 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "Several ER stress/UPR genes, including Immunoglobulin-heavy-chain binding protein (BiP), Activating Transcription Factor-4 and -6 (ATF4 and ATF6) and a spliced form of X-box binding protein (XBP1) were upregulated in lcSSc PBMCs, with the highest levels in patients with PAH. TG upregulated Heat shock proteins (HSP) and Interferon-regulated genes in control PBMCs. Selected HSP genes, particularly DNAJB1, and IFN-related genes were also found at significantly elevated levels in PBMCs from lcSSc patients, while IRF4 was significantly decreased. There was a positive correlation between DNAJB1 and severity of PAH disease (PAP) (r = 0.56, p<0.05) and between ER stress markers and IL-6 levels (r = 0.53, p< 0.0001) in lcSSc PBMCs." |
PAH | "Several ER stress/UPR genes, including Immunoglobulin-heavy-chain binding protein (BiP), Activating Transcription Factor-4 and -6 (ATF4 and ATF6) and a spliced form of X-box binding protein (XBP1) were upregulated in lcSSc PBMCs, with the highest levels in patients with PAH. TG upregulated Heat shock proteins (HSP) and Interferon-regulated genes in control PBMCs. Selected HSP genes, particularly DNAJB1, and IFN-related genes were also found at significantly elevated levels in PBMCs from lcSSc patients, while IRF4 was significantly decreased. There was a positive correlation between DNAJB1 and severity of PAH disease (PAP) (r = 0.56, p<0.05) and between ER stress markers and IL-6 levels (r = 0.53, p< 0.0001) in lcSSc PBMCs." |
| More detail of all Human literatures about HSPA5 | |
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Pathways and Diseases |
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Pathway | Activation of Chaperones by ATF6-alpha;PID Reactome;500130 |
Pathway | Antigen processing and presentation;KEGG PATHWAY;hsa04612 |
Pathway | Parkinson disease;PANTHER;P00049 |
Pathway | Protein export;KEGG PATHWAY;hsa03060 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | PERK regulated gene expression;PID Reactome;500132 |
Pathway | Activation of Chaperones by IRE1alpha;PID Reactome;500131 |
Pathway | prion pathway;PID BioCarta;100062 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Unfolded Protein Response;PID Reactome;500129 |
Pathway | Platelet degranulation;PID Reactome;500959 |
Pathway | Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141 |
Pathway | Prion diseases;KEGG PATHWAY;hsa05020 |
Disease | HIV infection;FunDO |
Disease | Cancer;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | Bipolar disorder;FunDO |
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External Links |
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Links to Entrez Gene | 3309 |
Links to all GeneRIF Items | 3309 |
Links to iHOP | 3309 |
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Sequence Information |
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Nucleotide Sequence |
>3309 : length: 1965 atgaagctctccctggtggccgcgatgctgctgctgctcagcgcggcgcgggccgaggag gaggacaagaaggaggacgtgggcacggtggtcggcatcgacctggggaccacctactcc tgcgtcggcgtgttcaagaacggccgcgtggagatcatcgccaacgatcagggcaaccgc atcacgccgtcctatgtcgccttcactcctgaaggggaacgtctgattggcgatgccgcc aagaaccagctcacctccaaccccgagaacacggtctttgacgccaagcggctcatcggc cgcacgtggaatgacccgtctgtgcagcaggacatcaagttcttgccgttcaaggtggtt gaaaagaaaactaaaccatacattcaagttgatattggaggtgggcaaacaaagacattt gctcctgaagaaatttctgccatggttctcactaaaatgaaagaaaccgctgaggcttat ttgggaaagaaggttacccatgcagttgttactgtaccagcctattttaatgatgcccaa cgccaagcaaccaaagacgctggaactattgctggcctaaatgttatgaggatcatcaac gagcctacggcagctgctattgcttatggcctggataagagggagggggagaagaacatc ctggtgtttgacctgggtggcggaaccttcgatgtgtctcttctcaccattgacaatggt gtcttcgaagttgtggccactaatggagatactcatctgggtggagaagactttgaccag cgtgtcatggaacacttcatcaaactgtacaaaaagaagacgggcaaagatgtcaggaaa gacaatagagctgtgcagaaactccggcgcgaggtagaaaaggccaaacgggccctgtct tctcagcatcaagcaagaattgaaattgagtccttctatgaaggagaagacttttctgag accctgactcgggccaaatttgaagagctcaacatggatctgttccggtctactatgaag cccgtccagaaagtgttggaagattctgatttgaagaagtctgatattgatgaaattgtt cttgttggtggctcgactcgaattccaaagattcagcaactggttaaagagttcttcaat ggcaaggaaccatcccgtggcataaacccagatgaagctgtagcgtatggtgctgctgtc caggctggtgtgctctctggtgatcaagatacaggtgacctggtactgcttgatgtatgt ccccttacacttggtattgaaactgtgggaggtgtcatgaccaaactgattccaaggaac acagtggtgcctaccaagaagtctcagatcttttctacagcttctgataatcaaccaact gttacaatcaaggtctatgaaggtgaaagacccctgacaaaagacaatcatcttctgggt acatttgatctgactggaattcctcctgctcctcgtggggtcccacagattgaagtcacc tttgagatagatgtgaatggtattcttcgagtgacagctgaagacaagggtacagggaac aaaaataagatcacaatcaccaatgaccagaatcgcctgacacctgaagaaatcgaaagg atggttaatgatgctgagaagtttgctgaggaagacaaaaagctcaaggagcgcattgat actagaaatgagttggaaagctatgcctattctctaaagaatcagattggagataaagaa aagctgggaggtaaactttcctctgaagataaggagaccatggaaaaagctgtagaagaa aagattgaatggctggaaagccaccaagatgctgacattgaagacttcaaagctaagaag aaggaactggaagaaattgttcaaccaattatcagcaaactctatggaagtgcaggccct cccccaactggtgaagaggatacagcagaaaaagatgagttgtag |
Protein Sequence |
>3309 : length: 654 MKLSLVAAMLLLLSAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGEEDTAEKDEL |