| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 3309 |
Name | HSPA5 |
Synonymous | BIP|GRP78|MIF2;heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa);HSPA5;heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
Definition | 78 kDa glucose-regulated protein|endoplasmic reticulum lumenal Ca(2+)-binding protein grp78|immunoglobulin heavy chain-binding protein |
Position | 9q33.3 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr9:127997132-128003609 | chr9:127997303-127997303 | rs12009 | Single_Nucleotides|eQTL|RABEPK, Motifs|Footprinting|MRF-2, Motifs|PWM|MRF-2, Motifs|PWM|Hoxa9, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|DNase-seq|Ag09319, Chromatin_Structure|DNase-seq|K562, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|DNase-seq|Hct116, Chromatin_Structure|DNase-seq|Hffmyc, Chromatin_Structure|DNase-seq|Hrgec, Chromatin_Structure|DNase-seq|Nb4, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Hrpe, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Gm12864, Chromatin_Structure|DNase-seq|Bj, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|H7es, Chromatin_Structure|DNase-seq|Be2c, Chromatin_Structure|DNase-seq|Aoaf, Chromatin_Structure|DNase-seq|Hac, Chromatin_Structure|DNase-seq|Hconf, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Hmvecdlyad, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Chromatin_Structure|DNase-seq|Hmveclly, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|DNase-seq|Helas3, Chromatin_Structure|DNase-seq|Hff, Chromatin_Structure|DNase-seq|Gm12865, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Rptec, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Panc1, Chromatin_Structure|DNase-seq|Gm12878, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Hcfaa, Chromatin_Structure|DNase-seq|Hpdlf, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Hpf, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|HEY1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|TFAP2A, Protein_Binding|ChIP-seq|TFAP2C, Protein_Binding|ChIP-seq|CCNT2, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A |
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Transcription Factors [Top] |
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Regulation From TransFac database |
PAK2(h) + GRP78(h) + NCK(h) <==> PAK2(h):GRP78(h):NCK(h) (binding) | GRP78(h) + AR(h) <==> GRP78(h):AR(h) (binding) | GRP78(h) + TRAP170(h) <==> GRP78(h):TRAP170(h) (binding) | Cas(h) + GRP78(h) <==> Cas(h):GRP78(h) (binding) | Lipophilin(h) + GRP78(h) <==> Lipophilin(h):GRP78(h) (binding) | Lipophilin(m) + GRP78(h) <==> Lipophilin(m):GRP78(h) (binding) | AMPKbeta-2(h) + AMPKg(h) + AMPKbeta-1(h) + Hsp50(h) + alpha-tubulin 1B(h) + Hsp90-alpha(h) + Hsp70-1(h) + GRP78(h) + AMPKalpha-1(r) <==> AMPKbeta-2(h):AMPKg(h):AMPKbeta-1(h):Hsp50(h):alpha-tubulin 1B(h):Hsp90-alpha(h):Hsp70-1(h):GRP78(h):AMPKalpha-1(r) (binding) | HSPA5(h) --> GRP78(h) (expression). | HCV-core-1B(HCV1B) --> GRP78(h) (increase of abundance) | HSPA5(h) --> GRP78(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
166 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 571 | Phosphoserine (By similarity). | Swiss-Prot 53.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr9 |
Promoter: 127042930 - 127044930 | Agilent_014791 |
chr9 |
Promoter: 127042930 - 127044930 | GSE27584 |
chr9 |
Promoter: 127042930 - 127044930 | Agilent_014791_44K |