| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 331 |
Name | XIAP |
Synonym | API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3;X-linked inhibitor of apoptosis;XIAP;X-linked inhibitor of apoptosis |
Definition | E3 ubiquitin-protein ligase XIAP|IAP-like protein|X-linked IAP|baculoviral IAP repeat-containing protein 4|inhibitor of apoptosis protein 3 |
Position | Xq25 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "The effect of GDF5 and BMP2 on proliferation and/or programmed cells death was assessed in isolated human vascular smooth muscle cells and mouse embryonic fibroblasts. We demonstrate that GDF5 and BMP2 prevent apoptosis induced by serum starvation in mouse embryonic fibroblasts but not in smooth muscle cells via the BMP receptor 2 (BMPR2), which is often mutated in hereditary cases of primary pulmonary hypertension. GDF5 and BMP2 stimulate the interaction of BMPR-2 with XIAP thereby reducing the ubiquitination of XIAP, which results in enhanced protein stability. ". |
| More detail of all Human literatures about XIAP | |
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Pathways and Diseases |
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Pathway | Apoptosis;Reactome;REACT:578 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | BMP receptor signaling;PID Curated;200123 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | NOD-like receptor signaling pathway;KEGG PATHWAY;hsa04621 |
Pathway | Apoptosis;KEGG PATHWAY;hsa04210 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | SMAC binds to IAPs;PID Reactome;500884 |
Pathway | SMAC-mediated dissociation of IAP:caspase complexes;PID Reactome;500934 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Caspase cascade in apoptosis;PID Curated;200148 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Disease | Lymphoproliferative syndrome, X-linked, 2;OMIM |
Disease | Ischemia;FunDO |
Disease | Other well-defined immunodeficiency syndromes;KEGG DISEASE;H00107 |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Copper metabolism disorder;FunDO |
Disease | Multiple sclerosis;FunDO |
Disease | Cancer;FunDO |
Disease | Familial Mediterranean Fever;GAD |
Disease | mevalonate kinase deficiency;GAD |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Immunologic deficiency syndrome;FunDO |
Disease | Cryopyrin-associated Periodic Syndromes;GAD |
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External Links |
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Links to Entrez Gene | 331 |
Links to all GeneRIF Items | 331 |
Links to iHOP | 331 |
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Sequence Information |
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Nucleotide Sequence |
>331 : length: 1494 atgacttttaacagttttgaaggatctaaaacttgtgtacctgcagacatcaataaggaa gaagaatttgtagaagagtttaatagattaaaaacttttgctaattttccaagtggtagt cctgtttcagcatcaacactggcacgagcagggtttctttatactggtgaaggagatacc gtgcggtgctttagttgtcatgcagctgtagatagatggcaatatggagactcagcagtt ggaagacacaggaaagtatccccaaattgcagatttatcaacggcttttatcttgaaaat agtgccacgcagtctacaaattctggtatccagaatggtcagtacaaagttgaaaactat ctgggaagcagagatcattttgccttagacaggccatctgagacacatgcagactatctt ttgagaactgggcaggttgtagatatatcagacaccatatacccgaggaaccctgccatg tatagtgaagaagctagattaaagtcctttcagaactggccagactatgctcacctaacc ccaagagagttagcaagtgctggactctactacacaggtattggtgaccaagtgcagtgc ttttgttgtggtggaaaactgaaaaattgggaaccttgtgatcgtgcctggtcagaacac aggcgacactttcctaattgcttctttgttttgggccggaatcttaatattcgaagtgaa tctgatgctgtgagttctgataggaatttcccaaattcaacaaatcttccaagaaatcca tccatggcagattatgaagcacggatctttacttttgggacatggatatactcagttaac aaggagcagcttgcaagagctggattttatgctttaggtgaaggtgataaagtaaagtgc tttcactgtggaggagggctaactgattggaagcccagtgaagacccttgggaacaacat gctaaatggtatccagggtgcaaatatctgttagaacagaagggacaagaatatataaac aatattcatttaactcattcacttgaggagtgtctggtaagaactactgagaaaacacca tcactaactagaagaattgatgataccatcttccaaaatcctatggtacaagaagctata cgaatggggttcagtttcaaggacattaagaaaataatggaggaaaaaattcagatatct gggagcaactataaatcacttgaggttctggttgcagatctagtgaatgctcagaaagac agtatgcaagatgagtcaagtcagacttcattacagaaagagattagtactgaagagcag ctaaggcgcctgcaagaggagaagctttgcaaaatctgtatggatagaaatattgctatc gtttttgttccttgtggacatctagtcacttgtaaacaatgtgctgaagcagttgacaag tgtcccatgtgctacacagtcattactttcaagcaaaaaatttttatgtcttaa |
Protein Sequence |
>331 : length: 497 MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK CPMCYTVITFKQKIFMS |