| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 331 |
Name | XIAP |
Synonymous | API3|BIRC4|IAP-3|ILP1|MIHA|XLP2|hIAP-3|hIAP3;X-linked inhibitor of apoptosis;XIAP;X-linked inhibitor of apoptosis |
Definition | E3 ubiquitin-protein ligase XIAP|IAP-like protein|X-linked IAP|baculoviral IAP repeat-containing protein 4|inhibitor of apoptosis protein 3 |
Position | Xq25 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for XIAP | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
ActR-II(h) + BMPR-IA(h) + XIAP(h) <==> ActR-II(h):BMPR-IA(h):XIAP(h) (binding) | BMPR-IA(h) + TAB1(h) + XIAP(h) <==> BMPR-IA(h):XIAP(h):TAB1(h) (binding) | TAB1(h) + XIAP(h) <==> XIAP(h):TAB1(h) (binding) | BMPR-IA(h) + XIAP(h) <==> BMPR-IA(h):XIAP(h) (binding) | Smac(h) + XIAP(h) <==> Smac(h):XIAP(h) (binding) | XIAP(h) + proCaspase-3(h) <==> XIAP(h):proCaspase-3(h) (binding) | Apaf-1(h):Caspase-9(h):Caspase-3(h) + XIAP(h) <==> Apaf-1(h):Caspase-9(h):Caspase-3(h):XIAP(h) (binding) | XIAP(h) --Caspase-3(h)--> protein remnants (processing) | Septin4-isoform1(h) + XIAP(h) <==> Septin4-isoform1(h):XIAP(h) (binding) | XIAP(h) + n ubiquitin(h) --> XIAP(h){ub(n)} (ubiquitination; automodification) | Smac-alpha(h) + XIAP(h) <==> Smac-alpha(h):XIAP(h) (binding) | Smac-delta(h) + XIAP(h) <==> Smac-delta(h):XIAP(h) (binding) | XIAP(h) + n ubiquitin(v.s.) --E1(rb),Ubc5A(h)--> XIAP(h){ub(n)} (ubiquitination) | XIAP(h) + n ubiquitin(v.s.) --E1(rb),UbcH6(h)--> XIAP(h){ub(n)} (ubiquitination) | proCaspase-3(h) + XIAP(h) + Cytochrome C(h) + Apaf-1(h) + proCaspase-9(h) <==> proCaspase-3(h):XIAP(h):Cytochrome C(h):Apaf-1(h):proCaspase-9(h) (binding) | XIAP(h) --Caspase-3(v.s.)--> XIAP-p29(h) + protein remnants (processing) | XIAP(h) --Omi(h)--> protein remnants (processing) | AKT-2(h) + XIAP(h) <==> AKT-2(h):XIAP(h) (binding) | XIAP(h) + NTP --AKT-2(h)--> XIAP(h){pS87} + NDP (phosphorylation) | Murr1(h) + XIAP(h) <==> Murr1(h):XIAP(h) (binding) | XIAP(h) --Omi(m.s.)--> protein remnants (cleavage) | XIAP(h) + Omi(h) <==> XIAP(h):Omi(h) (binding) | XIAP(h) + Caspase-9-p35(h) <==> XIAP(h):Caspase-9-p35(h) (binding) | XIAP(h) + Caspase-3-p17(h) <==> XIAP(h):Caspase-3-p17(h) (binding) | XIAP(h) + Caspase-3-p12(h) <==> XIAP(h):Caspase-3-p12(h) (binding) | Caspase-9-p35(h) + Apaf-1(h) + XIAP(h) <==> Caspase-9-p35(h):Apaf-1(h):XIAP(h) (binding) | XIAP(h) + Caspase-7-p19(h) <==> XIAP(h):Caspase-7-p19(h) (binding) | XIAP(h) --> XIAP-p30(h) + protein remnants (cleavage) | XIAP(h) --> protein remnants (degradation) | XIAP(h) + Smac(m.s.) <==> XIAP(h):Smac(m.s.) (binding) | XIAP(h) --> XIAP-p48(h) + protein remnants (cleavage) | XIAP(h) --> XIAP-p29(h) + protein remnants (cleavage) | Caspase-9(h) + XIAP(h) <==> Caspase-9(h):XIAP(h) (binding) | XIAP(h) + brca1(m.s.) <==> XIAP(h):brca1(m.s.) (binding) | brca1(h) + XIAP(h) <==> brca1(h):XIAP(h) (binding) | 2 XIAP(h) <==> (XIAP(h))2 (binding) | XIAP(h) + FLJ10204(h) <==> XIAP(h):FLJ10204(h) (binding) | XIAP(h) + DLC2(h) <==> XIAP(h):DLC2(h) (binding) | BIRC4(h) --> XIAP(h) (expression). | PKCdelta(h){pY311} --/ XIAP(h) (decrease of abundance) | XAF1(h) --> XIAP(h) (increase of cleavage) | TNF-alpha(h) --> XIAP(h) (increase of cleavage) | Caspase-7(h) + n ubiquitin(h) --XIAP(h)--> Caspase-7(h){ub(n)} (ubiquitination) | Smac(h) + n ubiquitin(v.s.) --XIAP(h)--> Smac(h){ub(n)} (ubiquitination) | Murr1(h) + n ubiquitin(h) --XIAP(h)--> Murr1(h){ub(n)} (ubiquitination) | Caspase-9(h) + XIAP(h) <==> Caspase-9(h):XIAP(h) (binding) | XIAP(h) --Omi(h)--> protein remnants (cleavage) | XIAP(h) + Smac(h) <==> XIAP(h):Smac(h) (binding) | Omi(h) + XIAP(h) <==> Omi(h):XIAP(h) (binding) | XIAP(h) + Caspase-3(h) <==> XIAP(h):Caspase-3(h) (binding) | XIAP(h) + Caspase-6(h) <==> XIAP(h):Caspase-6(h) (binding) | XIAP(h) + Caspase-9(h) <==> XIAP(h):Caspase-9(h) (binding) | XIAP(h) + Caspase-7(h) <==> XIAP(h):Caspase-7(h) (binding) | BIRC4(h) --> XIAP(h) (expression). |
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Post Transcriptional Modification [Top] | |||
There is no record for XIAP | |||
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chrX |
Promoter: 122820229 - 122822229 | GoldenGate_Methylation_Cancer_Panel_I |
chrX |
Promoter: 122820229 - 122822229 | GSE27584 |
chrX |
Promoter: 122820229 - 122822229 | Agilent_014791_44K |