Entrez Gene

General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information
Gene ID	348
Name	APOE
Synonym	AD2\|LDLCQ5\|LPG;apolipoprotein E;APOE;apolipoprotein E
Definition	apo-E\|apolipoprotein E3
Position	19q13.2
Gene Type	protein-coding
PAH Type	Description
PAH	An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.
PAH	ApoE(-/-)/IL-1R1(-/-) mice showed an even more severe pulmonary arterial hypertension phenotype.
PAH	"Also, the lack of insulin resistance and of PAH in Apoe–/– female mice fed a Western diet has been attributed to heightened levels of adiponectin."
PH	An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.
	More detail of all Human literatures about APOE
Pathways and Diseases
Pathway	Lipoprotein metabolism;PID Reactome;500795
Pathway	HDL-mediated lipid transport;PID Reactome;500797
Pathway	Metabolism of lipids and lipoproteins;Reactome;REACT:22258
Pathway	Alzheimer's disease;KEGG PATHWAY;hsa05010
Pathway	Chylomicron-mediated lipid transport;PID Reactome;500796
Disease	Encephalopathies;FunDO
Disease	Cardiovascular disease risk factors;NHGRI
Disease	Lipoprotein glomerulopathy;OMIM
Disease	Cardiovascular disease;FunDO
Disease	differential expansion rates of small abdominal aortic aneurysms;GAD
Disease	Psychomotor Agitation;GAD
Disease	neuropathy, Alzheimer's disease related;GAD
Disease	Vascular dementia;FunDO
Disease	Down syndrome;FunDO
Disease	Histiocytosis;FunDO
Disease	Depression;FunDO
Disease	Glaucoma;FunDO
Disease	longevity;GAD
Disease	life expectancy;GAD
Disease	early onset ischemic heart disease.;GAD
Disease	IMMUNE;GAD
Disease	Parkinson's disease;GAD
Disease	rapid motor decline;GAD
Disease	schizophrenia;GAD
Disease	Lupus Erythematosus, Systemic;GAD
Disease	glaucoma;GAD
Disease	Mycoses;FunDO
Disease	PSYCH;GAD
Disease	Psychotic disorder;FunDO
Disease	nephropathy, diabetic;GAD
Disease	Stroke;GAD
Disease	cholesterol, HDL cholesterol, LDL;GAD
Disease	quantitative traits;GAD
Disease	Malaria;FunDO
Disease	Inherited disorders of lipid/glycolipid metabolism;KEGG DISEASE
Disease	cholesterol cholesterol, HDL cholesterol, LDL lipoprotein triglycerides;GAD
Disease	Alzheimer disease-2;OMIM
Disease	Hyperhomocysteinemia;FunDO
Disease	lipoprotein;GAD
Disease	type III hyperlipoproteinemia;GAD
Disease	multiple sclerosis;GAD
Disease	Infectious lung disease;FunDO
Disease	memory decline;GAD
Disease	familial dysbetalipoproteinemia;GAD
Disease	C-reactive protein;GAD
Disease	outcome after head injury;GAD
Disease	apoA1;GAD
Disease	Macular Degeneration;GAD
Disease	Creutzfeldt-Jakob disease;GAD
Disease	myocardial infarct;GAD
Disease	dementia, vascular;GAD
Disease	Ischemia;FunDO
Disease	Alzheimer's disease (late onset);NHGRI
Disease	Cholelithiasis;FunDO
Disease	cardiovascular;GAD
Disease	high coronary heart disease risk particularly affects ser;GAD
Disease	hyperlipidemia;GAD
Disease	cholesterol, total;GAD
Disease	Brain imaging;NHGRI
Disease	lipid metabolism disorders;GAD
Disease	Liver cancer;FunDO
Disease	Herpes;FunDO
Disease	hypertension;GAD
Disease	Hyperlipoproteinemia, type III;KEGG DISEASE;H00156
Disease	Dermatitis;FunDO
Disease	cognitive function;GAD
Disease	anticholinergic challenge-induced memory impairment;GAD
Disease	coronary heart disease;GAD
Disease	cardiovascular disease;GAD
Disease	Subarachnoid hemorrhage;FunDO
Disease	Cirrhosis;FunDO
Disease	Epilepsy, Temporal Lobe;GAD
Disease	Drug abuse;FunDO
Disease	temporal lobe epilepsy;GAD
Disease	sleep-disordered breathing;GAD
Disease	diabetes, type 1;GAD
Disease	Alzheimer's disease (late onset);GAD
Disease	preeclampsia;GAD
Disease	Coronary Disease;GAD
Disease	triglycerides;GAD
Disease	HDL cholesterol;GAD
Disease	Confusion;GAD
Disease	Learning disorder;FunDO
Disease	Ovarian cancer;FunDO
Disease	Alzheimer Disease;GAD
Disease	Myocardial Infarction;GAD
Disease	Severe type III hyperlipoproteinemia;GAD
Disease	apolipoprotein E mutation [apolipoprotein E (delta149 Leu)];GAD
Disease	persistent vegetative state;GAD
Disease	Lupus erythematosus;FunDO
Disease	Macular degeneration;FunDO
Disease	LDL cholesterol;GAD
Disease	cholesterol, HDL;GAD
Disease	LDL cholesterol;NHGRI
Disease	anti-atherogenic lipoprotein profile;GAD
Disease	Brain imaging;GAD
Disease	AGING;GAD
Disease	Hypoglycemia;FunDO
Disease	Rectum cancer;FunDO
Disease	Prostate cancer;FunDO
Disease	Polycystic kidney;FunDO
Disease	psoriasis;GAD
Disease	PHARMACOGENOMIC;GAD
Disease	Dental plaque;FunDO
Disease	Plasma Lipid Levels;GAD
Disease	Autistic disorder;FunDO
Disease	METABOLIC;GAD
Disease	traumatic brain injury.;GAD
Disease	warfarin sensitivity;GAD
Disease	Genetic disorders;KEGG DISEASE
Disease	Coronary Artery Disease;GAD
Disease	CARDIOVASCULAR;GAD
Disease	Glomerulonephritis;FunDO
Disease	Hypertension/complications*;GAD
Disease	serum lipids;GAD
Disease	Stress disorder, post-traumatic;FunDO
Disease	Traumatic Brain Imjury;GAD
Disease	Neurodegenerative disorder;FunDO
Disease	left-handedness and visuospatial skills;GAD
Disease	Alzheimer's disease;KEGG DISEASE;H00056
Disease	Macular degeneration, age-related;OMIM
Disease	C-reactive protein;NHGRI
Disease	Gout;GAD
Disease	selenium;GAD
Disease	diabetic nephropathy;GAD
Disease	aneurysmal subarachnoid hemorrhage;GAD
Disease	Alzheimer's disease;GAD
Disease	lipids;GAD
Disease	carotid atherosclerosis;GAD
Disease	diabetes, type 2;GAD
Disease	Nervous system diseases;KEGG DISEASE
Disease	premature coronary heart disease.;GAD
Disease	obesity;GAD
Disease	Breast cancer;FunDO
Disease	apoB-100;GAD
Disease	Amyotrophic lateral sclerosis;FunDO
Disease	Embryoma;FunDO
Disease	hypercholesterolemia;GAD
Disease	Chronic simple glaucoma;FunDO
Disease	Dementia;GAD
Disease	VISION;GAD
Disease	Rheumatoid arthritis;FunDO
Disease	apoE;GAD
Disease	Liver disease;FunDO
Disease	Yersinia infection;FunDO
Disease	cognitive ability;GAD
Disease	Nephrosis;FunDO
Disease	Bone Mineral Density;GAD
Disease	Encephalitis;FunDO
Disease	Diabetes mellitus;FunDO
Disease	Alzheimer's disease;NHGRI
Disease	bulbar-onset motor neuron disease;GAD
Disease	Alzheimer`s Disease;GAD
Disease	Drug-Induced dyskinesia;FunDO
Disease	Cerebrovascular disorder;FunDO
Disease	Kidney failure;FunDO
Disease	Myocardial infarction susceptibility;OMIM
Disease	Hyperlipoproteinemia, type III;OMIM
Disease	NEUROLOGICAL;GAD
Disease	glaucoma, primary open-angle;GAD
Disease	Growth retardation;FunDO
Disease	cholesterol, LDL;GAD
Disease	cholesterol;GAD
Disease	Hyperlipidemia;FunDO
Disease	altered brain levels of apolipoprotein E;GAD
Disease	Biliary cancer;FunDO
Disease	endogenous hypertriglyceridemia and familial hypercholesterolemia;GAD
Disease	Sea-blue histiocyte disease;OMIM
Disease	Down Syndrome;GAD
Disease	Neurodegenerative diseases;KEGG DISEASE
Disease	cerebrovascular disease;GAD
Disease	RENAL;GAD
Disease	atherosclerosis, coronary;GAD
Disease	arterial wall thickness;GAD
External Links
Links to Entrez Gene	348
Links to all GeneRIF Items	348
Links to iHOP	348
Sequence Information
Nucleotide Sequence	>348 : length: 954 atgaaggttctgtgggctgcgttgctggtcacattcctggcaggatgccaggccaaggtg gagcaagcggtggagacagagccggagcccgagctgcgccagcagaccgagtggcagagc ggccagcgctgggaactggcactgggtcgcttttgggattacctgcgctgggtgcagaca ctgtctgagcaggtgcaggaggagctgctcagctcccaggtcacccaggaactgagggcg ctgatggacgagaccatgaaggagttgaaggcctacaaatcggaactggaggaacaactg accccggtggcggaggagacgcgggcacggctgtccaaggagctgcaggcggcgcaggcc cggctgggcgcggacatggaggacgtgtgcggccgcctggtgcagtaccgcggcgaggtg caggccatgctcggccagagcaccgaggagctgcgggtgcgcctcgcctcccacctgcgc aagctgcgtaagcggctcctccgcgatgccgatgacctgcagaagcgcctggcagtgtac caggccggggcccgcgagggcgccgagcgcggcctcagcgccatccgcgagcgcctgggg cccctggtggaacagggccgcgtgcgggccgccactgtgggctccctggccggccagccg ctacaggagcgggcccaggcctggggcgagcggctgcgcgcgcggatggaggagatgggc agccggacccgcgaccgcctggacgaggtgaaggagcaggtggcggaggtgcgcgccaag ctggaggagcaggcccagcagatacgcctgcaggccgaggccttccaggcccgcctcaag agctggttcgagcccctggtggaagacatgcagcgccagtgggccgggctggtggagaag gtgcaggctgccgtgggcaccagcgccgcccctgtgcccagcgacaatcactga
Protein Sequence	>348 : length: 317 MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK VQAAVGTSAAPVPSDNH