| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3791 |
Name | KDR |
Synonym | CD309|FLK1|VEGFR|VEGFR2;kinase insert domain receptor (a type III receptor tyrosine kinase);KDR;kinase insert domain receptor (a type III receptor tyrosine kinase) |
Definition | fetal liver kinase 1|fetal liver kinase-1|protein-tyrosine kinase receptor Flk-1|soluble VEGFR2|tyrosine kinase growth factor receptor|vascular endothelial growth factor receptor 2 |
Position | 4q11-q12 |
Gene Type | protein-coding |
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PAH Type |
Description |
PH | Supplemental Table 1: A list of genes and functional categories that comprises a PHrelevant gene module (PH-module). |
| More detail of all Human literatures about KDR | |
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Pathways and Diseases |
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Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | Neurophilin interactions with VEGF and VEGFR;PID Reactome;500650 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | S1P1 pathway;PID Curated;200071 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | VEGF ligand-receptor interactions;PID Reactome;500648 |
Pathway | Signaling by VEGF;Reactome;REACT:12529 |
Pathway | VEGF binds to VEGFR leading to receptor dimerization;PID Reactome;500649 |
Pathway | HIF-2-alpha transcription factor network;PID Curated;200030 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Notch-mediated HES/HEY network;PID Curated;200196 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Disease | Amyotrophic lateral sclerosis;FunDO |
Disease | Lupus erythematosus;FunDO |
Disease | kawasaki disease;GAD |
Disease | Dermatitis;FunDO |
Disease | Cardiovascular disease;FunDO |
Disease | IMMUNE;GAD |
Disease | Hemangioma, capillary infantile, susceptibility to;OMIM |
Disease | Retinal disease;FunDO |
Disease | Asthma;FunDO |
Disease | Cancer;FunDO |
Disease | Asthma;GAD |
Disease | Endometriosis;FunDO |
Disease | Mucocutaneous lymph node syndrome;FunDO |
Disease | Chronic obstructive airway disease;FunDO |
Disease | Hemangioma, capillary infantile, somatic;OMIM |
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External Links |
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Links to Entrez Gene | 3791 |
Links to all GeneRIF Items | 3791 |
Links to iHOP | 3791 |
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Sequence Information |
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Nucleotide Sequence |
>3791 : length: 4071 atgcagagcaaggtgctgctggccgtcgccctgtggctctgcgtggagacccgggccgcc tctgtgggtttgcctagtgtttctcttgatctgcccaggctcagcatacaaaaagacata cttacaattaaggctaatacaactcttcaaattacttgcaggggacagagggacttggac tggctttggcccaataatcagagtggcagtgagcaaagggtggaggtgactgagtgcagc gatggcctcttctgtaagacactcacaattccaaaagtgatcggaaatgacactggagcc tacaagtgcttctaccgggaaactgacttggcctcggtcatttatgtctatgttcaagat tacagatctccatttattgcttctgttagtgaccaacatggagtcgtgtacattactgag aacaaaaacaaaactgtggtgattccatgtctcgggtccatttcaaatctcaacgtgtca ctttgtgcaagatacccagaaaagagatttgttcctgatggtaacagaatttcctgggac agcaagaagggctttactattcccagctacatgatcagctatgctggcatggtcttctgt gaagcaaaaattaatgatgaaagttaccagtctattatgtacatagttgtcgttgtaggg tataggatttatgatgtggttctgagtccgtctcatggaattgaactatctgttggagaa aagcttgtcttaaattgtacagcaagaactgaactaaatgtggggattgacttcaactgg gaatacccttcttcgaagcatcagcataagaaacttgtaaaccgagacctaaaaacccag tctgggagtgagatgaagaaatttttgagcaccttaactatagatggtgtaacccggagt gaccaaggattgtacacctgtgcagcatccagtgggctgatgaccaagaagaacagcaca tttgtcagggtccatgaaaaaccttttgttgcttttggaagtggcatggaatctctggtg gaagccacggtgggggagcgtgtcagaatccctgcgaagtaccttggttacccaccccca gaaataaaatggtataaaaatggaataccccttgagtccaatcacacaattaaagcgggg catgtactgacgattatggaagtgagtgaaagagacacaggaaattacactgtcatcctt accaatcccatttcaaaggagaagcagagccatgtggtctctctggttgtgtatgtccca ccccagattggtgagaaatctctaatctctcctgtggattcctaccagtacggcaccact caaacgctgacatgtacggtctatgccattcctcccccgcatcacatccactggtattgg cagttggaggaagagtgcgccaacgagcccagccaagctgtctcagtgacaaacccatac ccttgtgaagaatggagaagtgtggaggacttccagggaggaaataaaattgaagttaat aaaaatcaatttgctctaattgaaggaaaaaacaaaactgtaagtacccttgttatccaa gcggcaaatgtgtcagctttgtacaaatgtgaagcggtcaacaaagtcgggagaggagag agggtgatctccttccacgtgaccaggggtcctgaaattactttgcaacctgacatgcag cccactgagcaggagagcgtgtctttgtggtgcactgcagacagatctacgtttgagaac ctcacatggtacaagcttggcccacagcctctgccaatccatgtgggagagttgcccaca cctgtttgcaagaacttggatactctttggaaattgaatgccaccatgttctctaatagc acaaatgacattttgatcatggagcttaagaatgcatccttgcaggaccaaggagactat gtctgccttgctcaagacaggaagaccaagaaaagacattgcgtggtcaggcagctcaca gtcctagagcgtgtggcacccacgatcacaggaaacctggagaatcagacgacaagtatt ggggaaagcatcgaagtctcatgcacggcatctgggaatccccctccacagatcatgtgg tttaaagataatgagacccttgtagaagactcaggcattgtattgaaggatgggaaccgg aacctcactatccgcagagtgaggaaggaggacgaaggcctctacacctgccaggcatgc agtgttcttggctgtgcaaaagtggaggcatttttcataatagaaggtgcccaggaaaag acgaacttggaaatcattattctagtaggcacggcggtgattgccatgttcttctggcta cttcttgtcatcatcctacggaccgttaagcgggccaatggaggggaactgaagacaggc tacttgtccatcgtcatggatccagatgaactcccattggatgaacattgtgaacgactg ccttatgatgccagcaaatgggaattccccagagaccggctgaagctaggtaagcctctt ggccgtggtgcctttggccaagtgattgaagcagatgcctttggaattgacaagacagca acttgcaggacagtagcagtcaaaatgttgaaagaaggagcaacacacagtgagcatcga gctctcatgtctgaactcaagatcctcattcatattggtcaccatctcaatgtggtcaac cttctaggtgcctgtaccaagccaggagggccactcatggtgattgtggaattctgcaaa tttggaaacctgtccacttacctgaggagcaagagaaatgaatttgtcccctacaagacc aaaggggcacgattccgtcaagggaaagactacgttggagcaatccctgtggatctgaaa cggcgcttggacagcatcaccagtagccagagctcagccagctctggatttgtggaggag aagtccctcagtgatgtagaagaagaggaagctcctgaagatctgtataaggacttcctg accttggagcatctcatctgttacagcttccaagtggctaagggcatggagttcttggca tcgcgaaagtgtatccacagggacctggcggcacgaaatatcctcttatcggagaagaac gtggttaaaatctgtgactttggcttggcccgggatatttataaagatccagattatgtc agaaaaggagatgctcgcctccctttgaaatggatggccccagaaacaatttttgacaga gtgtacacaatccagagtgacgtctggtcttttggtgttttgctgtgggaaatattttcc ttaggtgcttctccatatcctggggtaaagattgatgaagaattttgtaggcgattgaaa gaaggaactagaatgagggcccctgattatactacaccagaaatgtaccagaccatgctg gactgctggcacggggagcccagtcagagacccacgttttcagagttggtggaacatttg ggaaatctcttgcaagctaatgctcagcaggatggcaaagactacattgttcttccgata tcagagactttgagcatggaagaggattctggactctctctgcctacctcacctgtttcc tgtatggaggaggaggaagtatgtgaccccaaattccattatgacaacacagcaggaatc agtcagtatctgcagaacagtaagcgaaagagccggcctgtgagtgtaaaaacatttgaa gatatcccgttagaagaaccagaagtaaaagtaatcccagatgacaaccagacggacagt ggtatggttcttgcctcagaagagctgaaaactttggaagacagaaccaaattatctcca tcttttggtggaatggtgcccagcaaaagcagggagtctgtggcatctgaaggctcaaac cagacaagcggctaccagtccggatatcactccgatgacacagacaccaccgtgtactcc agtgaggaagcagaacttttaaagctgatagagattggagtgcaaaccggtagcacagcc cagattctccagcctgactcggggaccacactgagctctcctcctgtttaa |
Protein Sequence |
>3791 : length: 1356 MQSKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLD WLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQD YRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWD SKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGIELSVGE KLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRS DQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPAKYLGYPPP EIKWYKNGIPLESNHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECANEPSQAVSVTNPY PCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGE RVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTWYKLGPQPLPIHVGELPT PVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRKTKKRHCVVRQLT VLERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNR NLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWL LLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPL GRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVN LLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLK RRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLA SRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDR VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTML DCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVS CMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDS GMVLASEELKTLEDRTKLSPSFGGMVPSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYS SEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV |