Entrez Gene

Basic Information
Gene ID	3791
Name	KDR
Synonymous	CD309\|FLK1\|VEGFR\|VEGFR2;kinase insert domain receptor (a type III receptor tyrosine kinase);KDR;kinase insert domain receptor (a type III receptor tyrosine kinase)
Definition	fetal liver kinase 1\|fetal liver kinase-1\|protein-tyrosine kinase receptor Flk-1\|soluble VEGFR2\|tyrosine kinase growth factor receptor\|vascular endothelial growth factor receptor 2
Position	4q11-q12
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB [Top]
	There is no record for KDR

Regulation From TransFac database
Transcription Factors [Top]
VEGFR-2(h) + VRAP(h) <==> VEGFR-2(h):VRAP(h) (binding)
VEGFR-2(h) + Sck(h) <==> VEGFR-2(h):Sck(h) (binding)
VEGF-165(h) + VEGFR-2(h) <==> VEGF-165(h):VEGFR-2(h) (binding)
VEGFR-2(h) + Grb-2(pg) <==> VEGFR-2(h):Grb-2(pg) (binding)
VEGFR-2(h) + Nck-1(pg) <==> VEGFR-2(h):Nck-1(pg) (binding)
VEGFR-2(h) + GAP(pg) <==> VEGFR-2(h):GAP(pg) (binding)
VEGFR-2(h) + SHP-1(pg) <==> VEGFR-2(h):SHP-1(pg) (binding)
VEGFR-2(h) + SHP-2(pg) <==> VEGFR-2(h):SHP-2(pg) (binding)
VEGFR-2(h) + beta3-integrin(h) <==> VEGFR-2(h):beta3-integrin(h) (binding)
IQGAP1(h) + VEGFR-2(h) <==> IQGAP1(h):VEGFR-2(h) (binding)
VEGFR-2(h) + ATP --> VEGFR-2(h){pY1054} + ADP (phosphorylation)
VEGFR-2(h) + ATP --> VEGFR-2(h){pY} + ADP (phosphorylation)
VEGFR-2(h) + ATP --> VEGFR-2(h){pY951}{pY1175} + ADP (phosphorylation)
KDR(h) --> VEGFR-2(h) (expression).
myoferlin(h) --> VEGFR-2(h) (increase of abundance)
c-Cbl(m) --> VEGFR-2(h) (increase of abundance)
dynamin2(h) --/ VEGFR-2(h) (decrease of abundance)
p52Shc(pg) + NTP --VEGFR-2(h)--> p52Shc(pg){p} + NDP (phosphorylation)
p42Shc(pg) + NTP --VEGFR-2(h)--> p42Shc(pg){p} + NDP (phosphorylation)
VEGFR-2(h) + ATP --> VEGFR-2(h){pY} + ADP (automodification)
KDR(h) --> VEGFR-2(h) (expression).
myoferlin(h) --> VEGFR-2(h) (increase of abundance)

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
46	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
66	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
96	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
143	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
158	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
245	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
318	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
374	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
395	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
511	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
523	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
580	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
613	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
619	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
631	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
675	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
704	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
721	N-linked (GlcNAc...) (Potential).		Swiss-Prot 53.0
1059	Phosphotyrosine (by autocatalysis) (Bysimilarity).		Swiss-Prot 53.0
801	Phosphotyrosine	11741094	Phospho.ELM 6.0
1214	Phosphotyrosine (KDR)	12023952;11387210	Phospho.ELM 6.0
1175	Phosphotyrosine (KDR)	10579917;11387210;10749680;14532277	Phospho.ELM 6.0
996	Phosphotyrosine (KDR)	10579917	Phospho.ELM 6.0
1054	Phosphotyrosine (KDR)	10579917	Phospho.ELM 6.0
1059	Phosphotyrosine (KDR)	10579917;11435426	Phospho.ELM 6.0
951	Phosphotyrosine (KDR)	10579917;11435426	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr4	Promoter: 55686019 - 55688019	Agilent_014791
chr4	Promoter: 55686019 - 55688019	GoldenGate_Methylation_Cancer_Panel_I
chr4	Promoter: 55686019 - 55688019	GSE27584
chr4	Promoter: 55686019 - 55688019	Agilent_014791_44K

ENCODE RegulomeDB [Top]