| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3953 |
Name | LEPR |
Synonym | CD295|LEP-R|LEPRD|OB-R|OBR;leptin receptor;LEPR;leptin receptor |
Definition | OB receptor|huB219 |
Position | 1p31 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | The percentage of circulating regulatory T-lymphocytes expressing leptin receptor was higher in idiopathic pulmonary arterial hypertension and scleroderma-associated pulmonary arterial hypertension compared with controls. |
| More detail of all Human literatures about LEPR | |
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Pathways and Diseases |
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Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | reversal of insulin resistance by leptin;PID BioCarta;100117 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Neuroactive ligand-receptor interaction;KEGG PATHWAY;hsa04080 |
Disease | HEMATOLOGICAL;GAD |
Disease | soluble leptin receptor levels;GAD |
Disease | bone density;GAD |
Disease | Bladder cancer;FunDO |
Disease | fat mass;GAD |
Disease | cholesterol, HDL;GAD |
Disease | diabetes, type 2;GAD |
Disease | obesity;GAD |
Disease | Cholelithiasis;FunDO |
Disease | obesity (BMI = 30 kg/m2);GAD |
Disease | Eating disorder;FunDO |
Disease | Breast cancer;FunDO |
Disease | Stomach cancer;FunDO |
Disease | Ulcerative colitis;FunDO |
Disease | Neoplasm metastasis;FunDO |
Disease | Hypercholesterolemia;FunDO |
Disease | HIV infection;FunDO |
Disease | hypertension;GAD |
Disease | fatty acid;GAD |
Disease | Pituitary tumor;FunDO |
Disease | Fatty Liver;GAD |
Disease | Soluble leptin receptor levels;NHGRI |
Disease | Obesity, morbid, with hypogonadism;OMIM |
Disease | Diabetes Mellitus, Type 2;GAD |
Disease | Rheumatoid arthritis;FunDO |
Disease | Leukemia;FunDO |
Disease | METABOLIC;GAD |
Disease | Schizophrenia;FunDO |
Disease | Weight Loss;GAD |
Disease | Colon cancer;FunDO |
Disease | Nephrosis;FunDO |
Disease | body mass index and waist circumference;GAD |
Disease | Spinal dysraphism;FunDO |
Disease | Gastritis;FunDO |
Disease | Diabetes mellitus;FunDO |
Disease | body mass obesity;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Multiple sclerosis;FunDO |
Disease | early-onset prostate cancer;GAD |
Disease | Endometrium cancer;FunDO |
Disease | CANCER;GAD |
Disease | other metabolic traits;GAD |
Disease | Weight Gain;GAD |
Disease | triglycerides;GAD |
Disease | lipoprotein;GAD |
Disease | Endometriosis;FunDO |
Disease | insulin;GAD |
Disease | Overfeeding;GAD |
Disease | Diabetes Complications;GAD |
Disease | Hypertension;FunDO |
Disease | cholesterol, LDL;GAD |
Disease | body mass;GAD |
Disease | breast cancer;GAD |
Disease | C-reactive protein;GAD |
Disease | Other metabolic traits;NHGRI |
Disease | Obesity;FunDO |
Disease | Anorexia nervosa;FunDO |
Disease | C-reactive protein;NHGRI |
Disease | Serum Insulin Levels in obese;GAD |
Disease | leptin;GAD |
Disease | uric acid;GAD |
Disease | Insulin in Obese Women with Impaired Glucose Tolerance (IGT);GAD |
Disease | Protein-energy malnutrition;FunDO |
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External Links |
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Links to Entrez Gene | 3953 |
Links to all GeneRIF Items | 3953 |
Links to iHOP | 3953 |
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Sequence Information |
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Nucleotide Sequence |
>3953 : length: 2691 atgatttgtcaaaaattctgtgtggttttgttacattgggaatttatttatgtgataact gcgtttaacttgtcatatccaattactccttggagatttaagttgtcttgcatgccacca aattcaacctatgactacttccttttgcctgctggactctcaaagaatacttcaaattcg aatggacattatgagacagctgttgaacctaagtttaattcaagtggtactcacttttct aacttatccaaaacaactttccactgttgctttcggagtgagcaagatagaaactgctcc ttatgtgcagacaacattgaaggaaagacatttgtttcaacagtaaattctttagttttt caacaaatagatgcaaactggaacatacagtgctggctaaaaggagacttaaaattattc atctgttatgtggagtcattatttaagaatctattcaggaattataactataaggtccat cttttatatgttctgcctgaagtgttagaagattcacctctggttccccaaaaaggcagt tttcagatggttcactgcaattgcagtgttcatgaatgttgtgaatgtcttgtgcctgtg ccaacagccaaactcaacgacactctccttatgtgtttgaaaatcacatctggtggagta attttccagtcacctctaatgtcagttcagcccataaatatggtgaagcctgatccacca ttaggtttgcatatggaaatcacagatgatggtaatttaaagatttcttggtccagccca ccattggtaccatttccacttcaatatcaagtgaaatattcagagaattctacaacagtt atcagagaagctgacaagattgtctcagctacatccctgctagtagacagtatacttcct gggtcttcgtatgaggttcaggtgaggggcaagagactggatggcccaggaatctggagt gactggagtactcctcgtgtctttaccacacaagatgtcatatactttccacctaaaatt ctgacaagtgttgggtctaatgtttcttttcactgcatctataagaaggaaaacaagatt gttccctcaaaagagattgtttggtggatgaatttagctgagaaaattcctcaaagccag tatgatgttgtgagtgatcatgttagcaaagttacttttttcaatctgaatgaaaccaaa cctcgaggaaagtttacctatgatgcagtgtactgctgcaatgaacatgaatgccatcat cgctatgctgaattatatgtgattgatgtcaatatcaatatctcatgtgaaactgatggg tacttaactaaaatgacttgcagatggtcaaccagtacaatccagtcacttgcggaaagc actttgcaattgaggtatcataggagcagcctttactgttctgatattccatctattcat cccatatctgagcccaaagattgctatttgcagagtgatggtttttatgaatgcattttc cagccaatcttcctattatctggctacacaatgtggattaggatcaatcactctctaggt tcacttgactctccaccaacatgtgtccttcctgattctgtggtgaagccactgcctcca tccagtgtgaaagcagaaattactataaacattggattattgaaaatatcttgggaaaag ccagtctttccagagaataaccttcaattccagattcgctatggtttaagtggaaaagaa gtacaatggaagatgtatgaggtttatgatgcaaaatcaaaatctgtcagtctcccagtt ccagacttgtgtgcagtctatgctgttcaggtgcgctgtaagaggctagatggactggga tattggagtaattggagcaatccagcctacacagttgtcatggatataaaagttcctatg agaggacctgaattttggagaataattaatggagatactatgaaaaaggagaaaaatgtc actttactttggaagcccctgatgaaaaatgactcattgtgcagtgttcagagatatgtg ataaaccatcatacttcctgcaatggaacatggtcagaagatgtgggaaatcacacgaaa ttcactttcctgtggacagagcaagcacatactgttacggttctggccatcaattcaatt ggtgcttctgttgcaaattttaatttaaccttttcatggcctatgagcaaagtaaatatc gtgcagtcactcagtgcttatcctttaaacagcagttgtgtgattgtttcctggatacta tcacccagtgattacaagctaatgtattttattattgagtggaaaaatcttaatgaagat ggtgaaataaaatggcttagaatctcttcatctgttaagaagtattatatccatgatcat tttatccccattgagaagtaccagttcagtctttacccaatatttatggaaggagtggga aaaccaaagataattaatagtttcactcaagatgatattgaaaaacaccagagtgatgca ggtttatatgtaattgtgccagtaattatttcctcttccatcttattgcttggaacatta ttaatatcacaccaaagaatgaaaaagctattttgggaagatgttccgaaccccaagaat tgttcctgggcacaaggacttaattttcagaagagaacggacattctttga |
Protein Sequence |
>3953 : length: 896 MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNS NGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVF QQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGS FQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPP LGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILP GSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKI VPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHH RYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIH PISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPP SSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPV PDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNV TLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSI GASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNED GEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDA GLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKRTDIL |