| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 3953 |
Name | LEPR |
Synonymous | CD295|LEP-R|LEPRD|OB-R|OBR;leptin receptor;LEPR;leptin receptor |
Definition | OB receptor|huB219 |
Position | 1p31 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr1:65886248-66107242 | chr1:65897951-65897951 | rs7602 | Single_Nucleotides|eQTL|LEPR, Chromatin_Structure|DNase-seq|H7es, Protein_Binding|ChIP-seq|GATA1 | chr1:65886248-66107242 | chr1:65897981-65897981 | rs1045895 | Single_Nucleotides|eQTL|BC009533, Single_Nucleotides|eQTL|LEPR, Single_Nucleotides|eQTL|MIRN101-1, Chromatin_Structure|DNase-seq|H7es, Protein_Binding|ChIP-seq|GATA1 | chr1:65886248-66107242 | chr1:65911672-65911672 | rs9436748 | Single_Nucleotides|eQTL|LEPR, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|CEBPB, Protein_Binding|ChIP-seq|CEBPB | chr1:65886248-66107242 | chr1:65946506-65946506 | rs2025803 | Single_Nucleotides|eQTL|LEPR, Protein_Binding|ChIP-seq|POLR2A | chr1:65886248-66107242 | chr1:65949878-65949878 | rs2025805 | Single_Nucleotides|eQTL|LEPR, Chromatin_Structure|DNase-seq|Caco2, Chromatin_Structure|DNase-seq|Hepg2 | chr1:65886248-66107242 | chr1:65950230-65950230 | rs7524834 | Single_Nucleotides|eQTL|LEPR, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Hepg2, Chromatin_Structure|FAIRE|Hepg2, Chromatin_Structure|DNase-seq|Caco2, Protein_Binding|ChIP-seq|AR, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|FOXA1, Protein_Binding|ChIP-seq|RXRA, Protein_Binding|ChIP-seq|EP300, Protein_Binding|ChIP-seq|FOXA2, Protein_Binding|ChIP-seq|FOXA1, Protein_Binding|ChIP-seq|EP300, Protein_Binding|ChIP-seq|JUND, Protein_Binding|ChIP-seq|HDAC2, Protein_Binding|ChIP-seq|FOSL2, Protein_Binding|ChIP-seq|NR3C1, Protein_Binding|ChIP-seq|NR3C1, Protein_Binding|ChIP-seq|JUND, Protein_Binding|ChIP-seq|RFX5, Protein_Binding|ChIP-seq|TCF4 | chr1:65886248-66107242 | chr1:65950340-65950340 | rs7513047 | Single_Nucleotides|eQTL|LEPR, Chromatin_Structure|DNase-seq|Hepg2, Chromatin_Structure|FAIRE|Hepg2, Chromatin_Structure|DNase-seq|Caco2, Protein_Binding|ChIP-seq|AR, Protein_Binding|ChIP-seq|FOXA1, Protein_Binding|ChIP-seq|FOXA1, Protein_Binding|ChIP-seq|HDAC2, Protein_Binding|ChIP-seq|FOSL2, Protein_Binding|ChIP-seq|NR3C1, Protein_Binding|ChIP-seq|NR3C1, Protein_Binding|ChIP-seq|RFX5 | chr1:65886248-66107242 | chr1:65952741-65952741 | rs17412723 | Single_Nucleotides|eQTL|LEPR, Chromatin_Structure|DNase-seq|K562 | chr1:65886248-66107242 | chr1:65987205-65987205 | rs11587159 | Single_Nucleotides|eQTL|LEPR, Chromatin_Structure|DNase-seq|Medullo | chr1:65886248-66107242 | chr1:66035739-66035739 | rs3790432 | Single_Nucleotides|eQTL|LEPR, Motifs|PWM|HNF3beta, Motifs|PWM|HNF3, Motifs|PWM|FOXJ2, Motifs|PWM|Foxd3, Motifs|PWM|HFH1(FOXQ1), Motifs|PWM|FOXD3, Motifs|PWM|FOXI1, Motifs|PWM|FOXfactors, Motifs|PWM|HFH4(FOXJ1), Motifs|PWM|HFH3(FOXI1), Motifs|PWM|HNF3, Motifs|PWM|FOXJ2, Motifs|PWM|HNF3alpha, Motifs|PWM|FOXO4, Motifs|PWM|FOXO3A, Motifs|PWM|FOXO3, Motifs|PWM|Freac-7, Motifs|PWM|HFH1(FOXQ1), Motifs|PWM|FOXI1, Motifs|PWM|HFH3(FOXI1), Motifs|PWM|HFH8(FOXF1A), Motifs|PWM|TEF, Motifs|PWM|Foxa2, Motifs|PWM|Foxj1, Motifs|PWM|Foxj3, Motifs|PWM|Foxk1, Motifs|PWM|Foxl1, Motifs|PWM|Tbp, Protein_Binding|ChIP-seq|SMARCA4 | chr1:65886248-66107242 | chr1:66036028-66036028 | rs3790431 | Single_Nucleotides|eQTL|LEPR, Motifs|Footprinting|HNF1, Motifs|PWM|HNF1, Chromatin_Structure|DNase-seq|Rptec | chr1:65886248-66107242 | chr1:66043019-66043019 | rs3790426 | Single_Nucleotides|eQTL|LEPR, Single_Nucleotides|eQTL|LEPR, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|TAL1 |
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Transcription Factors [Top] |
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Regulation From TransFac database |
2 lepr-B(h) <==> (lepr-B(h))2 (oligomerization) | lepr-B(h) + ATP --> lepr-B(h){pY} + ADP (phosphorylation) | leptin(m.s.) + lepr-B(h) <==> leptin(m.s.):lepr-B(h) (binding) | LEPR(h) --> lepr-B(h) (expression). | leptin(h) + lepr(h) <==> leptin(h):lepr(h) (binding) | lepr(h) --> lepr(h) (expression). | lepr(h){gly} --> lepr(h) + NDP-Gly (deglycosylation) | leptin(m.s.) + lepr-A(h) <==> leptin(m.s.):lepr-A(h) (binding) | LEPR(h) --> lepr-A(h) (expression). | leptin(m.s.) + lepr-C(h) <==> leptin(m.s.):lepr-C(h) (binding) | LEPR(h) --> lepr-C(h) (expression). | leptin(m.s.) + lepr-D(h) <==> leptin(m.s.):lepr-D(h) (binding) | LEPR(h) --> lepr-D(h) (expression). | leptin(h) + lepr-E(h) <==> leptin(h):lepr-E(h) (binding) | LEPR(h) --> lepr-E(h) (expression). | lepr-E(h){gly} --> lepr-E(h) + NDP-Gly (deglycosylation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
23 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 41 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 56 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 73 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 81 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 98 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 187 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 206 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 276 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 347 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 397 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 516 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 624 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 659 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 688 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 697 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 728 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 750 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 986 | Phosphotyrosine (by JAK2) (Bysimilarity). | Swiss-Prot 53.0 | 1141 | Phosphotyrosine (by JAK2) (Bysimilarity). | Swiss-Prot 53.0 | 1141 | Phosphotyrosine | 14625304 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr1 |
Promoter: 65657406 - 65659406 | Agilent_014791 |
chr1 |
Promoter: 65657406 - 65659406 | GSE27584 |
chr1 |
Promoter: 65657406 - 65659406 | GSE27584 |
chr1 |
Promoter: 65657406 - 65659406 | GSE27584 |
chr1 |
Promoter: 65657406 - 65659406 | Agilent_014791_44K |
chr1 |
Promoter: 65657406 - 65659406 | E-GEOD-20553 |
chr1 |
Promoter: 65657406 - 65659406 | E-GEOD-20553 |
chr1 |
Promoter: 65657406 - 65659406 | E-GEOD-20553 |