| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 3984 |
Name | LIMK1 |
Synonym | LIMK|LIMK-1;LIM domain kinase 1;LIMK1;LIM domain kinase 1 |
Definition | LIM motif-containing protein kinase |
Position | 7q11.23 |
Gene Type | protein-coding |
|
PAH Type |
Description |
PAH | Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. |
| More detail of all Human literatures about LIMK1 | |
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Pathways and Diseases |
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Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | Sema3A PAK dependent Axon repulsion;PID Reactome;500076 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | role of mal in rho-mediated activation of srf;PID BioCarta;100114 |
Pathway | ccr3 signaling in eosinophils;PID BioCarta;100215 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Sema4D induced cell migration and growth-cone collapse;PID Reactome;500074 |
Pathway | rho cell motility signaling pathway;PID BioCarta;100041 |
Pathway | Caspase cascade in apoptosis;PID Curated;200148 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | RhoA signaling pathway;PID Curated;200007 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | RAC1 signaling pathway;PID Curated;200190 |
Pathway | rac1 cell motility signaling pathway;PID BioCarta;100056 |
Pathway | Cytoskeletal regulation by Rho GTPase;PANTHER;P00016 |
Disease | brain aneurysm;GAD |
Disease | Breast cancer;FunDO |
Disease | CARDIOVASCULAR;GAD |
Disease | Prostate cancer;FunDO |
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External Links |
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Links to Entrez Gene | 3984 |
Links to all GeneRIF Items | 3984 |
Links to iHOP | 3984 |
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Sequence Information |
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Nucleotide Sequence |
>3984 : length: 1842 atgctgttggcttcagccccaagaagacgccgcttcctccagagggctaagtgttgtgac tgcagtgcctccctgtcgcaccagtactatgagaaggatgggcagctcttctgcaagaag gactactgggcccgctatggcgagtcctgccatgggtgctctgagcaaatcaccaaggga ctggttatggtggctggggagctgaagtaccaccccgagtgtttcatctgcctcacgtgt gggacctttatcggtgacggggacacctacacgctggtggagcactccaagctgtactgc gggcactgctactaccagactgtggtgacccccgtcatcgagcagatcctgcctgactcc cctggctcccacctgccccacaccgtcaccctggtgtccatcccagcctcatctcatggc aagcgtggactttcagtctccattgaccccccgcacggcccaccgggctgtggcaccgag cactcacacaccgtccgcgtccagggagtggatccgggctgcatgagcccagatgtgaag aattccatccacgtcggagaccggatcttggaaatcaatggcacgcccatccgaaatgtg cccctggacgagattgacctgctgattcaggaaaccagccgcctgctccagctgaccctc gagcatgaccctcacgatacactgggccacgggctggggcctgagaccagccccctgagc tctccggcttatactcccagcggggaggcgggcagctctgcccggcagaaacctgtcttg aggagctgcagcatcgacaggtctccgggcgctggctcactgggctccccggcctcccag cgcaaggacctgggtcgctctgagtccctccgcgtagtctgccggccacaccgcatcttc cggccgtcggacctcatccacggggaggtgctgggcaagggctgcttcggccaggctatc aaggtgacacaccgtgagacaggtgaggtgatggtgatgaaggagctgatccggttcgac gaggagacccagaggacgttcctcaaggaggtgaaggtcatgcgatgcctggaacacccc aacgtgctcaagttcatcggggtgctctacaaggacaagaggctcaacttcatcactgag tacatcaagggcggcacgctccggggcatcatcaagagcatggacagccagtacccatgg agccagagagtgagctttgccaaggacatcgcatcagggatggcctacctccactccatg aacatcatccaccgagacctcaactcccacaactgcctggtccgcgagaacaagaatgtg gtggtggctgacttcgggctggcgcgtctcatggtggacgagaagactcagcctgagggc ctgcggagcctcaagaagccagaccgcaagaagcgctacaccgtggtgggcaacccctac tggatggcacctgagatgatcaacggccgcagctatgatgagaaggtggatgtgttctcc tttgggatcgtcctgtgcgagatcatcgggcgggtgaacgcagaccctgactacctgccc cgcaccatggactttggcctcaacgtgcgaggattcctggaccgctactgccccccaaac tgccccccgagcttcttccccatcaccgtgcgctgttgcgatctggaccccgagaagagg ccatcctttgtgaagctggaacactggctggagaccctccgcatgcacctggccggccac ctgccactgggcccacagctggagcagctggacagaggtttctgggagacctaccggcgc ggcgagagcggactgcctgcccaccctgaggtccccgactga |
Protein Sequence |
>3984 : length: 613 MLLASAPRRRRFLQRAKCCDCSASLSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKG LVMVAGELKYHPECFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDS PGSHLPHTVTLVSIPASSHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVK NSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLS SPAYTPSGEAGSSARQKPVLRSCSIDRSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIF RPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHP NVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSM NIIHRDLNSHNCLVRENKNVVVADFGLARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPY WMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPN CPPSFFPITVRCCDLDPEKRPSFVKLEHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRR GESGLPAHPEVPD |