| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 3984 |
Name | LIMK1 |
Synonymous | LIMK|LIMK-1;LIM domain kinase 1;LIMK1;LIM domain kinase 1 |
Definition | LIM motif-containing protein kinase |
Position | 7q11.23 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for LIMK1 | |||
Transcription Factors [Top] |
|
Regulation From TransFac database |
LIMK1(h) + p65PAK(h) <==> LIMK1(h):p65PAK(h) (binding) | LIMK1(h) + CREB1(m.s.) <==> LIMK1(h):CREB1(m.s.) (binding) | LIMK1(h) --> LIMK1(h) (expression). | LIMK1-isoform1(h) + parkin-isoform1(h) <==> LIMK1-isoform1(h):parkin-isoform1(h) (binding) | parkin-isoform1(h) + LIMK1-isoform1(h) + CHIP(h) <==> parkin-isoform1(h):LIMK1-isoform1(h):CHIP(h) (binding) | LIMK1-isoform1(h) + CHIP(h) <==> LIMK1-isoform1(h):CHIP(h) (binding) | Hsp70-1(h) + LIMK1-isoform1(h) <==> Hsp70-1(h):LIMK1-isoform1(h) (binding) | LIMK1-isoform1(h) + ubiquitin(h) --parkin-isoform1(h)--> LIMK1-isoform1(h){ub} (ubiquitination) | LIMK1-isoform1(h) + ubiquitin(h) --E1(h),UbcH7(h),parkin-isoform1(h)--> LIMK1-isoform1(h){ub} (ubiquitination) | LIMK1-isoform1(h) + ATP --> LIMK1-isoform1(h){p} + ADP (phosphorylation) | LIMK1(h) --> LIMK1-isoform1(h) (expression). | cofilin-1(h) + ATP --LIMK1-isoform1(h)--> cofilin-1(h){pS3} + ADP (phosphorylation) | cofilin-2(h) + ATP --LIMK1-isoform1(h)--> cofilin-2(h){p} + ADP (phosphorylation) | LIMK1(h) --> LIMK1-isoform2(h) (expression). | LIMK1(h) --> LIMK1-isoform3(h) (expression). |
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Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
298 | Phosphoserine. | Swiss-Prot 53.0 | 310 | Phosphoserine. | Swiss-Prot 53.0 | 508 | Phosphothreonine (by ROCK1). | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 73134592 - 73136592 | GoldenGate_Methylation_Cancer_Panel_I |
chr7 |
Promoter: 73134592 - 73136592 | GSE27584 |
chr7 |
Promoter: 73134592 - 73136592 | Agilent_014791_44K |