| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4086 |
Name | SMAD1 |
Synonym | BSP-1|BSP1|JV4-1|JV41|MADH1|MADR1;SMAD family member 1;SMAD1;SMAD family member 1 |
Definition | MAD homolog 1|MAD, mothers against decapentaplegic homolog 1|Mad-related protein 1|SMAD, mothers against DPP homolog 1|TGF-beta signaling protein 1|mothers against DPP homolog 1|mothers against decapentaplegic homolog 1|transforming growth factor-beta sig |
Position | 4q31 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. |
PAH | Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. |
PH | Smad signaling in the rat model of monocrotaline pulmonary hypertension. |
PH | Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo. |
| More detail of all Human literatures about SMAD1 | |
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Pathways and Diseases |
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Pathway | ctcf: first multivalent nuclear factor;PID BioCarta;100194 |
Pathway | BMP receptor signaling;PID Curated;200123 |
Pathway | alk in cardiac myocytes;PID BioCarta;100244 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Signaling by BMP;Reactome;REACT:12034 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | ALK1 signaling events;PID Curated;200126 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | BMP Signalling Pathway;BioCyc;PWY66-11 |
Pathway | ALK2 signaling events;PID Curated;200138 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Disease | Pancreas cancer;FunDO |
Disease | Lung cancer;FunDO |
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External Links |
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Links to Entrez Gene | 4086 |
Links to all GeneRIF Items | 4086 |
Links to iHOP | 4086 |
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Sequence Information |
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Nucleotide Sequence |
>4086 : length: 1398 atgaatgtgacaagtttattttcctttacaagtccagctgtgaagagacttcttgggtgg aaacagggcgatgaagaagaaaaatgggcagagaaagctgttgatgctttggtgaaaaaa ctgaagaaaaagaaaggtgccatggaggaactggaaaaggccttgagctgcccagggcaa ccgagtaactgtgtcaccattccccgctctctggatggcaggctgcaagtctcccaccgg aagggactgcctcatgtcatttactgccgtgtgtggcgctggcccgatcttcagagccac catgaactaaaaccactggaatgctgtgagtttccttttggttccaagcagaaggaggtc tgcatcaatccctaccactataagagagtagaaagccctgtacttcctcctgtgctggtt ccaagacacagcgaatataatcctcagcacagcctcttagctcagttccgtaacttagga caaaatgagcctcacatgccactcaacgccacttttccagattctttccagcaacccaac agccacccgtttcctcactctcccaatagcagttacccaaactctcctgggagcagcagc agcacctaccctcactctcccaccagctcagacccaggaagccctttccagatgccagct gatacgcccccacctgcttacctgcctcctgaagaccccatgacccaggatggctctcag ccgatggacacaaacatgatggcgcctcccctgccctcagaaatcaacagaggagatgtt caggcggttgcttatgaggaaccaaaacactggtgctctattgtctactatgagctcaac aatcgtgtgggtgaagcgttccatgcctcctccacaagtgtgttggtggatggtttcact gatccttccaacaataagaaccgtttctgccttgggctgctctccaatgttaaccggaat tccactattgaaaacaccaggcggcatattggaaaaggagttcatctttattatgttgga ggggaggtgtatgccgaatgccttagtgacagtagcatctttgtgcaaagtcggaactgc aactaccatcatggatttcatcctactactgtttgcaagatccctagtgggtgtagtctg aaaatttttaacaaccaagaatttgctcagttattggcacagtctgtgaaccatggattt gagacagtctatgagcttacaaaaatgtgtactatacgtatgagctttgtgaagggctgg ggagcagaataccaccgccaggatgttactagcaccccctgctggattgagatacatctg cacggccccctccagtggctggataaagttcttactcaaatgggttcacctcataatcct atttcatctgtatcttaa |
Protein Sequence |
>4086 : length: 465 MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEV CINPYHYKRVESPVLPPVLVPRHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN SHPFPHSPNSSYPNSPGSSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMTQDGSQ PMDTNMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS |