| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4086 |
Name | SMAD1 |
Synonymous | BSP-1|BSP1|JV4-1|JV41|MADH1|MADR1;SMAD family member 1;SMAD1;SMAD family member 1 |
Definition | MAD homolog 1|MAD, mothers against decapentaplegic homolog 1|Mad-related protein 1|SMAD, mothers against DPP homolog 1|TGF-beta signaling protein 1|mothers against DPP homolog 1|mothers against decapentaplegic homolog 1|transforming growth factor-beta sig |
Position | 4q31 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for SMAD1 | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
Smad1(h) + NTP --BMPR-IA(h)--> Smad1(h){p} + NDP (phosphorylation) | Smad1(h) + NTP --BMPR-IB(m)--> Smad1(h){p} + NDP (phosphorylation) | Smad1(h) + Smurf-2(h) <==> Smad1(h):Smurf-2(h) (binding) | Smad1(h) + n ubiquitin(h) --Smurf-2(h)--> Smad1(h){ub(n)} (ubiquitination) | Smad1(h) + HRS(m) <==> Smad1(h):HRS(m) (binding) | Smad1(h) + NTP --ERK2(m)--> Smad1(h){p} + NDP (phosphorylation) | Smad1(h) + NTP --BMPR-IB(h)--> Smad1(h){p} + NDP (phosphorylation) | Smad1(h) + NTP --ActR-I(h)--> Smad1(h){p} + NDP (phosphorylation) | Smad1(h) + NTP --ALK-1(h)--> Smad1(h){p} + NDP (phosphorylation) | BMP7(h) + BMPR-II(h) + BMPR-IB(m) + Smad1(h) <==> BMP7(h):BMPR-II(h):BMPR-IB(m):Smad1(h) (binding) | Smad1(h) + Smad6(h) <==> Smad1(h):Smad6(h) (binding) | Smad1(h) + NTP --BMP7(h):BMPR-II(h):BMPR-IB(h)--> Smad1(h){p} + NDP (phosphorylation) | Smad1(h) + NTP --BMP7(h):BMPR-II(h):ActR-I(h)--> Smad1(h){p} + NDP (phosphorylation) | Smad1(h) + smad4(h) <==> Smad1(h):smad4(h) (binding) | Smad1(h) + ATP --BMP7(h):BMPR-II(h):ActR-I(h)--> Smad1(h){p} (phosphorylation) | Smad1(h) + Smurf-1(h) <==> Smad1(h):Smurf-1(h) (binding) | smad4(h) + Smad1(h) + RbAp48(h) + RbAp46(h) + sin3a(h) + HDAC1(h) + Nkx3-2(c) <==> smad4(h):Smad1(h):RbAp48(h):RbAp46(h):sin3a(h):HDAC1(h):Nkx3-2(c) (binding) | Smad1(h) --> vent-2(x) (DNA binding). | Smad1(h) --> IBSP(h) (DNA binding). | SMAD1(h) --> Smad1(h) (expression). | Smad1(h) --> vent-2(x) (DNA binding). | Smad1(h) + EIF4ENIF1(m.s.) <==> Smad1(h):EIF4ENIF1(m.s.) (binding) | Smad1(h) + ZNF198(m.s.) <==> Smad1(h):ZNF198(m.s.) (binding) | PEX6(m.s.) + Smad1(h) <==> PEX6(m.s.):Smad1(h) (binding) | Smad1(h) + SF3B2(m.s.) <==> Smad1(h):SF3B2(m.s.) (binding) | p68(m) + Smad1(h) <==> p68(m):Smad1(h) (binding) | Smad1(h) + Erbin(m.s.) <==> Smad1(h):Erbin(m.s.) (binding) | Smad1(h) + Dvl-1(m.s.) <==> Smad1(h):Dvl-1(m.s.) (binding) | Smad1(h) + Par3(m.s.) <==> Smad1(h):Par3(m.s.) (binding) | Smad1(h) + col1a2(m.s.) <==> Smad1(h):col1a2(m.s.) (binding) | Smad1(h) + COL3A1(m.s.) <==> Smad1(h):COL3A1(m.s.) (binding) | Smad1(h) + COL5A2(m.s.) <==> Smad1(h):COL5A2(m.s.) (binding) | Smad1(h) + Nkx3-2(c) <==> Smad1(h):Nkx3-2(c) (binding) | Smad1(h) --> c-myc(h) (DNA binding). | SMAD1(h) --> Smad1(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
463 | Phosphoserine. | Swiss-Prot 53.0 | 465 | Phosphoserine. | Swiss-Prot 53.0 | 462 | Phosphoserine (TGFbR1;BMPR1) | 9748228;9136927;10085121;9335504 | Phospho.ELM 6.0 | 463 | Phosphoserine (TGFbR1;BMPR1) | 9748228;9136927;10085121;9335504 | Phospho.ELM 6.0 | 465 | Phosphoserine (TGFbR1;BMPR1) | 9748228;9136927;10085121;9335504 | Phospho.ELM 6.0 | 187 | Phosphoserine (MAPK1) | 9335504 | Phospho.ELM 6.0 | 195 | Phosphoserine (MAPK1) | 9335504 | Phospho.ELM 6.0 | 206 | Phosphoserine (MAPK1) | 9335504 | Phospho.ELM 6.0 | 214 | Phosphoserine (MAPK1) | 9335504 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr4 |
Promoter: 146621907 - 146623907 | Agilent_014791 |
chr4 |
Promoter: 146621907 - 146623907 | GSE27584 |
chr4 |
Promoter: 146620901 - 146622901 | GSE27584 |
chr4 |
Promoter: 146621907 - 146623907 | Agilent_014791_44K |