| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 4087 |
Name | SMAD2 |
Synonym | JV18|JV18-1|MADH2|MADR2|hMAD-2|hSMAD2;SMAD family member 2;SMAD2;SMAD family member 2 |
Definition | MAD homolog 2|SMAD, mothers against DPP homolog 2|Sma- and Mad-related protein 2|mother against DPP homolog 2|mothers against decapentaplegic homolog 2 |
Position | 18q21.1 |
Gene Type | protein-coding |
|
PAH Type |
Description |
PAH | A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension. |
PH | "The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension." |
| More detail of all Human literatures about SMAD2 | |
|
Pathways and Diseases |
|
Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Regulation of cytoplasmic and nuclear SMAD2/3 signaling;PID Curated;200152 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Glypican 1 network;PID Curated;200021 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | tgf beta signaling pathway;PID BioCarta;100017 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Signaling by TGF beta;Reactome;REACT:6844 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Disease | Colorectal cancer;KEGG DISEASE;H00020 |
Disease | Amyotrophic lateral sclerosis;FunDO |
Disease | Cancers;KEGG DISEASE |
Disease | Dermatitis;FunDO |
Disease | Skin cancer;FunDO |
Disease | Asthma;FunDO |
Disease | Cancer;FunDO |
Disease | Cancers of the digestive system;KEGG DISEASE |
|
External Links |
|
Links to Entrez Gene | 4087 |
Links to all GeneRIF Items | 4087 |
Links to iHOP | 4087 |
|
Sequence Information |
|
Nucleotide Sequence |
>4087 : length: 1404 atgtcgtccatcttgccattcacgccgccagttgtgaagagactgctgggatggaagaag tcagctggtgggtctggaggagcaggcggaggagagcagaatgggcaggaagaaaagtgg tgtgagaaagcagtgaaaagtctggtgaagaagctaaagaaaacaggacgattagatgag cttgagaaagccatcaccactcaaaactgtaatactaaatgtgttaccataccaagcact tgctctgaaatttggggactgagtacaccaaatacgatagatcagtgggatacaacaggc ctttacagcttctctgaacaaaccaggtctcttgatggtcgtctccaggtatcccatcga aaaggattgccacatgttatatattgccgattatggcgctggcctgatcttcacagtcat catgaactcaaggcaattgaaaactgcgaatatgcttttaatcttaaaaaggatgaagta tgtgtaaacccttaccactatcagagagttgagacaccagttttgcctccagtattagtg ccccgacacaccgagatcctaacagaacttccgcctctggatgactatactcactccatt ccagaaaacactaacttcccagcaggaattgagccacagagtaattatattccagaaacg ccacctcctggatatatcagtgaagatggagaaacaagtgaccaacagttgaatcaaagt atggacacaggctctccagcagaactatctcctactactctttcccctgttaatcatagc ttggatttacagccagttacttactcagaacctgcattttggtgttcgatagcatattat gaattaaatcagagggttggagaaaccttccatgcatcacagccctcactcactgtagat ggctttacagacccatcaaattcagagaggttctgcttaggtttactctccaatgttaac cgaaatgccacggtagaaatgacaagaaggcatataggaagaggagtgcgcttatactac ataggtggggaagtttttgctgagtgcctaagtgatagtgcaatctttgtgcagagcccc aattgtaatcagagatatggctggcaccctgcaacagtgtgtaaaattccaccaggctgt aatctgaagatcttcaacaaccaggaatttgctgctcttctggctcagtctgttaatcag ggttttgaagccgtctatcagctaactagaatgtgcaccataagaatgagttttgtgaaa gggtggggagcagaataccgaaggcagacggtaacaagtactccttgctggattgaactt catctgaatggacctctacagtggttggacaaagtattaactcagatgggatccccttca gtgcgttgctcaagcatgtcataa |
Protein Sequence |
>4087 : length: 467 MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDE LEKAITTQNCNTKCVTIPSTCSEIWGLSTPNTIDQWDTTGLYSFSEQTRSLDGRLQVSHR KGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFNLKKDEVCVNPYHYQRVETPVLPPVLV PRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQS MDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVD GFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSP NCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVK GWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS |