| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 4087 |
Name | SMAD2 |
Synonymous | JV18|JV18-1|MADH2|MADR2|hMAD-2|hSMAD2;SMAD family member 2;SMAD2;SMAD family member 2 |
Definition | MAD homolog 2|SMAD, mothers against DPP homolog 2|Sma- and Mad-related protein 2|mother against DPP homolog 2|mothers against decapentaplegic homolog 2 |
Position | 18q21.1 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr18:45357922-45457515 | chr18:45410742-45410742 | rs1792668 | Single_Nucleotides|eQTL|SMAD2, Chromatin_Structure|DNase-seq|Hmvecdlyad, Chromatin_Structure|FAIRE|Gm12891 |
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Transcription Factors [Top] |
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Regulation From TransFac database |
SARA(h) + Smad2-L(h) <==> SARA(h):Smad2-L(h) (binding) | Smad2-L(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad2-L(h){p} (phosphorylation) | Smad2-L(h) + NTP --TGFbetaR-I(h)--> Smad2-L(h){p} + NDP (phosphorylation) | Smad2-L(h) + smad4(h) --TGFbetaR-I(h)--> Smad2-L(h):smad4(h) (binding) | Smad2-L(h) + Smad3(h) --TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding) | Smad2-L(h) + Smurf-2(h) <==> Smad2-L(h):Smurf-2(h) (binding) | Smad2-L(h) + n ubiquitin(h) --Smurf-2(h)--> Smad2-L(h){ub(n)} (ubiquitination) | Smad2-L(h) + SARA(h) + HRS(m) <==> Smad2-L(h):SARA(h):HRS(m) (binding) | Smad2-L(h) + NTP --CaMKII-alpha(r)--> Smad2-L(h){p} + NDP (phosphorylation) | Smad2-L(h) + Smad3(h) --TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding) | Smad2-L(h) + smad4(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad2-L(h):smad4(h) (binding) | Smad2-L(h) + Smad3(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding) | TGFbetaR-II(h) + TGFbetaR-I(h) + Smad2-L(h) <==> TGFbetaR-II(h):TGFbetaR-I(h):Smad2-L(h) (binding) | Smad2-L(h) + NTP --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad2-L(h){p} + NDP (phosphorylation) | Smad2-L(h) + ATP --TGFbetaR-I(h)--> Smad2-L(h){p} + ADP (phosphorylation) | p300(h) + Smad2-L(h) <==> p300(h):Smad2-L(h) (binding). | Smad2-L(h) + TGIF(h) <==> Smad2-L(h):TGIF(h) (binding). | FOXH1(m) + Smad2-L(h) <==> FOXH1(m):Smad2-L(h) (binding). | SKIP(h) + Smad2-L(h) <==> SKIP(h):Smad2-L(h) (binding). | p62Dok-1(m) + Smad2-L(h) <==> p62Dok-1(m):Smad2-L(h) (binding) | CBP(m) + Smad2-L(h) <==> CBP(m):Smad2-L(h) (binding) | Smad2-L(h) + 5 ATP --ERK1(h)--> Smad2-L(h){pT8}{pT220}{pS245}{pS250}{pS255} + 5 ADP (phosphorylation) | Smad2-L(h) + 5 ATP --> Smad2-L(h){pT8}{pT220}{pS245}{pS250}{pS255} + 5 ADP (phosphorylation) | Smad2-L(h) + smad4(h) <==> Smad2-L(h):smad4(h) (binding) | Smad2-L(h) + calmodulin(m) <==> Smad2-L(h):calmodulin(m) (binding) | TGFbeta1(h) --> Smad2-L(h) (activation; phosphorylation) | SMAD2(h) --> Smad2-L(h) (expression). | calmodulin(m) --/ Smad2-L(h) (decrease of abundance) | SMAD2(h) --> Smad2 (437 AA)(h) (expression). | Sox9(r) + Smad2(h) <==> Sox9(r):Smad2(h) (binding) | c-Myc(h) + Smad2(h) <==> c-Myc(h):Smad2(h) (binding) | smad4(h) + Smad2(h) <==> smad4(h):Smad2(h) (binding) | c-Myc(m.s.) + Smad2(h) <==> c-Myc(m.s.):Smad2(h) (binding) | Smad2(h) + p53(h) <==> Smad2(h):p53(h) (binding) | Smad2(h) --> collagen-IIalpha1(h) (increase of abundance) | Smad2(h) + ATP --> Smad2(h){p} + ADP (phosphorylation) | Smad2(h) + Dab2(h) <==> Smad2(h):Dab2(h) (binding) | Smad2(h) + ATP --> Smad2(h){pS} + ADP (phosphorylation) | Smad2(h) + PDK1(h) <==> Smad2(h):PDK1(h) (binding) | Smad2(h) + acetyl-CoA --> Smad2(h){aceK} + CoA (acetylation) | Smad2(h) + acetyl-CoA --p300(m.s.)--> Smad2(h){aceK} + CoA (acetylation) | Smad2(h) --> TGFB2(h) (DNA binding). | Smad2(h) --> FBLN5(h) (DNA binding). | Smad2(h) --> TNC(h) (DNA binding). | Smad2(h) --> MMP13(h) (DNA binding). | Smad2(h) --> ACTA2(h) (DNA binding). | Smad2(h) + 2 ATP --> Smad2(h){pS465}{pS467} + 2 ADP (phosphorylation) | c-Ski(h) + Smad2(h) + Smad4(h) <==> c-Ski(h):Smad2(h):Smad4(h) (binding) | Smad2(h) --> c-myc(h) (DNA binding). | Smad2(h) + 2 ATP --> Smad2(h){pS}2 + 2 ADP (phosphorylation) | SMAD2(h) --> Smad2(h) (expression). | CHIP(h) --/ Smad2(h) (decrease of abundance) | SRC3(h) --> Smad2(h) (increase of abundance) | SMAD2(h) --> Smad2-S(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
8 | Phosphothreonine (by MAPK3). | Swiss-Prot 53.0 | 220 | Phosphothreonine (Probable). | Swiss-Prot 53.0 | 240 | Phosphoserine (by CAMK2). | Swiss-Prot 53.0 | 245 | Phosphoserine (Probable). | Swiss-Prot 53.0 | 250 | Phosphoserine (Probable). | Swiss-Prot 53.0 | 255 | Phosphoserine (Probable). | Swiss-Prot 53.0 | 465 | Phosphoserine. | Swiss-Prot 53.0 | 467 | Phosphoserine. | Swiss-Prot 53.0 | 464 | Phosphoserine (TGFbR1) | 9892009 | Phospho.ELM 6.0 | 465 | Phosphoserine (TGFbR1) | 9892009 | Phospho.ELM 6.0 | 467 | Phosphoserine (TGFbR1) | 9892009 | Phospho.ELM 6.0 | 8 | Phosphothreonine (MAP2K1) | 11027280;17081983 | Phospho.ELM 6.0 | 220 | Phosphothreonine (MAP2K1) | 11027280 | Phospho.ELM 6.0 | 245 | Phosphoserine (MAP2K1) | 11027280 | Phospho.ELM 6.0 | 250 | Phosphoserine (MAP2K1) | 11027280 | Phospho.ELM 6.0 | 255 | Phosphoserine (MAP2K1) | 11027280 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr18 |
Promoter: 43711010 - 43713010 | Agilent_014791 |
chr18 |
Promoter: 43711010 - 43713010 | GoldenGate_Methylation_Cancer_Panel_I |
chr18 |
Promoter: 43710424 - 43712424 | GoldenGate_Methylation_Cancer_Panel_I |
chr18 |
Promoter: 43711010 - 43713010 | GSE27584 |
chr18 |
Promoter: 43710424 - 43712424 | GSE27584 |
chr18 |
Promoter: 43711010 - 43713010 | Agilent_014791_44K |
chr18 |
Promoter: 43710424 - 43712424 | Agilent_014791_44K |
chr18 |
Promoter: 43711010 - 43713010 | Agilent_014791 |
chr18 |
Promoter: 43710424 - 43712424 | Agilent_014791 |