| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4088 |
Name | SMAD3 |
Synonym | HSPC193|HsT17436|JV15-2|LDS1C|LDS3|MADH3;SMAD family member 3;SMAD3;SMAD family member 3 |
Definition | MAD homolog 3|MAD, mothers against decapentaplegic homolog 3|SMA- and MAD-related protein 3|SMAD, mothers against DPP homolog 3|hMAD-3|hSMAD3|mad homolog JV15-2|mad protein homolog|mad3|mothers against DPP homolog 3|mothers against decapentaplegic homolog |
Position | 15q22.33 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "The transforming growth factor-beta/Smad2,3 signalling axis is impaired in experimental pulmonary hypertension." |
| More detail of all Rat literatures about SMAD3 | |
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Pathways and Diseases |
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Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Regulation of Telomerase;PID Curated;200072 |
Pathway | Regulation of cytoplasmic and nuclear SMAD2/3 signaling;PID Curated;200152 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Chronic myeloid leukemia;KEGG PATHWAY;hsa05220 |
Pathway | Validated targets of C-MYC transcriptional activation;PID Curated;200045 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | cell cycle: g1/s check point;PID BioCarta;100160 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | nfkb activation by nontypeable hemophilus influenzae;PID BioCarta;100088 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | tgf beta signaling pathway;PID BioCarta;100017 |
Pathway | Cell cycle;KEGG PATHWAY;hsa04110 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Signaling by TGF beta;Reactome;REACT:6844 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Colorectal cancer;KEGG PATHWAY;hsa05210 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Disease | Amyotrophic lateral sclerosis;FunDO |
Disease | Herpes;FunDO |
Disease | Embryoma;FunDO |
Disease | Dermatitis;FunDO |
Disease | Adenoma;FunDO |
Disease | Prostate cancer;FunDO |
Disease | Bacteremia;GAD |
Disease | Systemic scleroderma;FunDO |
Disease | CARDIOVASCULAR;GAD |
Disease | Scleroderma;FunDO |
Disease | Coronary heart disease;NHGRI |
Disease | Coronary Disease;GAD |
Disease | Rabies;FunDO |
Disease | Polyarthritis;FunDO |
Disease | Asthma;NHGRI |
Disease | Eating disorder;FunDO |
Disease | INFECTION;GAD |
Disease | Stomach cancer;FunDO |
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External Links |
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Links to Entrez Gene | 4088 |
Links to all GeneRIF Items | 4088 |
Links to iHOP | 4088 |
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Sequence Information |
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Nucleotide Sequence |
>4088 : length: 963 atggagctgtgtgagttcgccttcaatatgaagaaggacgaggtctgcgtgaatccctac cactaccagagagtagagacaccagttctacctcctgtgttggtgccacgccacacagag atcccggccgagttccccccactggacgactacagccattccatccccgaaaacactaac ttccccgcaggcatcgagccccagagcaatattccagagaccccaccccctggctacctg agtgaagatggagaaaccagtgaccaccagatgaaccacagcatggacgcaggttctcca aacctatccccgaatccgatgtccccagcacataataacttggacctgcagccagttacc tactgcgagccggccttctggtgctccatctcctactacgagctgaaccagcgcgtcggg gagacattccacgcctcgcagccatccatgactgtggatggcttcaccgacccctccaat tcggagcgcttctgcctagggctgctctccaatgtcaacaggaatgcagcagtggagctg acacggagacacatcggaagaggcgtgcggctctactacatcggaggggaggtcttcgca gagtgcctcagtgacagcgctatttttgtccagtctcccaactgtaaccagcgctatggc tggcacccggccaccgtctgcaagatcccaccaggatgcaacctgaagatcttcaacaac caggagttcgctgccctcctggcccagtcggtcaaccagggctttgaggctgtctaccag ttgacccgaatgtgcaccatccgcatgagcttcgtcaaaggctggggagcggagtacagg agacagactgtgaccagtaccccctgctggattgagctgcacctgaatgggcctttgcag tggcttgacaaggtcctcacccagatgggctccccaagcatccgctgttccagtgtgtct tag |
Protein Sequence |
>4088 : length: 320 MELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTN FPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVT YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVEL TRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNN QEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQ WLDKVLTQMGSPSIRCSSVS |