Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

4088

Name

SMAD3

Synonymous

HSPC193|HsT17436|JV15-2|LDS1C|LDS3|MADH3;SMAD family member 3;SMAD3;SMAD family member 3

Definition

MAD homolog 3|MAD, mothers against decapentaplegic homolog 3|SMA- and MAD-related protein 3|SMAD, mothers against DPP homolog 3|hMAD-3|hSMAD3|mad homolog JV15-2|mad protein homolog|mad3|mothers against DPP homolog 3|mothers against decapentaplegic homolog

Position

15q22.33

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

There is no record for SMAD3

Transcription Factors   [Top]

Regulation From TransFac database

Smad3(h) + NTP --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad3(h){p} + NDP (phosphorylation)
Smad3(h) + ATP --TGFbetaR-I(h)--> Smad3(h){p} + ADP (phosphorylation)
Smad2-L(h) + Smad3(h) --TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding)
Smad3(h) + Smurf-2(h) <==> Smad3(h):Smurf-2(h) (binding)
SARA(h) + Smad3(h) <==> SARA(h):Smad3(h) (binding)
HEF1(h) + Smad3(h) <==> HEF1(h):Smad3(h) (binding)
Smad2-L(h) + Smad3(h) --TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding)
TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h) + Smad3(h) <==> TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h):Smad3(h) (binding)
Smad3(h) + smad4(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad3(h):smad4(h) (binding)
Smad2-L(h) + Smad3(h) --TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h)--> Smad2-L(h):Smad3(h) (binding)
Smad3(h) + smad4(h) --TGFbetaR-I(h)--> Smad3(h):smad4(h) (binding)
Smad3(h) + NTP --PKCgamma(r)--> Smad3(h){p} + NDP (phosphorylation)
Smad3(h) --> MMP1(h) (DNA binding).
Smad3(h) --> JUN(h) (DNA binding).
Smad3(h) --> Col7A1(h) (DNA binding).
Smad3(h) --> SERPINE1(h) (DNA binding).
Smad3(h) --> Junb(m) (DNA binding).
Smad3(h) --> SMAD7(m) (DNA binding).
Smad3(h) --> vent-2(x) (DNA binding).
Smad3(h) + TGIF(h) <==> Smad3(h):TGIF(h) (binding).
SKIP(h) + Smad3(h) <==> SKIP(h):Smad3(h) (binding).
p62Dok-1(m) + Smad3(h) <==> p62Dok-1(m):Smad3(h) (binding)
MAGI-2(m) + Smad3(h) <==> MAGI-2(m):Smad3(h) (binding)
ActR-II(m) + MAGI-2(m) + Smad3(h) <==> ActR-II(m):MAGI-2(m):Smad3(h) (binding)
beta-catenin(h) + Smad3(h) <==> beta-catenin(h):Smad3(h) (binding)
LEF-1(m) + Smad3(h) <==> LEF-1(m):Smad3(h) (binding)
LEF1-isoform1(h) + Smad3(h) <==> LEF1-isoform1(h):Smad3(h) (binding)
Evi-1(h) + Smad3(h) <==> Evi-1(h):Smad3(h) (binding)
Smad3(h) + smad4(h) <==> Smad3(h):smad4(h) (binding)
Smad3(h) --> twin(x) (DNA binding; transactivation).
Smad3(h) + HIF-1alpha(h) <==> Smad3(h):HIF-1alpha(h) (binding)
HNF-4alpha(h) + Smad3(h) <==> HNF-4alpha(h):Smad3(h) (binding).
HNF-4alpha(r) + Smad3(h) <==> HNF-4alpha(r):Smad3(h) (binding).
Smad3(h) --> PTHLH(h) (DNA binding; transactivation).
Smad3(h) --> COL1A2(h) (DNA binding; transactivation).
Smad3(h) + NICD1(m) <==> Smad3(h):NICD1(m) (binding)
Smad3(h) + axin(r) <==> Smad3(h):axin(r) (binding)
conductin(r) + Smad3(h) <==> conductin(r):Smad3(h) (binding)
axin(r) + Smad3(h) + TGFbetaR-I(m.s.) <==> axin(r):Smad3(h):TGFbetaR-I(m.s.) (binding)
SARA(m.s.) + Smad3(h) <==> SARA(m.s.):Smad3(h) (binding)
Smad3(h) --> Smad3(h) (translocation)
4E-T(m) + Smad3(h) <==> 4E-T(m):Smad3(h) (binding)
Sf3b-2(m) + Smad3(h) <==> Sf3b-2(m):Smad3(h) (binding)
Smad3(h) + Pex-6(m) <==> Smad3(h):Pex-6(m) (binding)
Smad3(h) + Znf-198(m) <==> Smad3(h):Znf-198(m) (binding)
EIF4ENIF1(m.s.) + Smad3(h) <==> EIF4ENIF1(m.s.):Smad3(h) (binding)
SF3B2(m.s.) + Smad3(h) <==> SF3B2(m.s.):Smad3(h) (binding)
PEX6(m.s.) + Smad3(h) <==> PEX6(m.s.):Smad3(h) (binding)
ZNF198(m.s.) + Smad3(h) <==> ZNF198(m.s.):Smad3(h) (binding)
p68(m) + Smad3(h) <==> p68(m):Smad3(h) (binding)
Dvl-1(m) + Smad3(h) <==> Dvl-1(m):Smad3(h) (binding)
Par3(m) + Smad3(h) <==> Par3(m):Smad3(h) (binding)
Smad3(h) + Erbin(m) <==> Smad3(h):Erbin(m) (binding)
Dvl-1(m.s.) + Smad3(h) <==> Dvl-1(m.s.):Smad3(h) (binding)
Erbin(m.s.) + Smad3(h) <==> Erbin(m.s.):Smad3(h) (binding)
Smad3(h) + Par3(m.s.) <==> Smad3(h):Par3(m.s.) (binding)
col1a2(m) + Smad3(h) <==> col1a2(m):Smad3(h) (binding)
COL3A-1(m) + Smad3(h) <==> COL3A-1(m):Smad3(h) (binding)
COL5A-2(m) + Smad3(h) <==> COL5A-2(m):Smad3(h) (binding)
Smad3(h) + col1a2(m.s.) <==> Smad3(h):col1a2(m.s.) (binding)
COL3A1(m.s.) + Smad3(h) <==> COL3A1(m.s.):Smad3(h) (binding)
COL5A2(m.s.) + Smad3(h) <==> COL5A2(m.s.):Smad3(h) (binding)
Smad3(h) + AR-isoform1(h) <==> Smad3(h):AR-isoform1(h) (binding)
Smad3(h) + HDAC1(h) <==> Smad3(h):HDAC1(h) (binding)
HDAC1(h) + Smad3(h) <==> HDAC1(h):Smad3(h) (binding)
c-Ski(m.s.) + Smad3(h) <==> c-Ski(m.s.):Smad3(h) (binding)
SnoN(m.s.) + Smad3(h) <==> SnoN(m.s.):Smad3(h) (binding)
Smad3(h) + TGIF(m.s.) <==> Smad3(h):TGIF(m.s.) (binding)
sin3a(m.s.) + Smad3(h) <==> sin3a(m.s.):Smad3(h) (binding)
TCF-4(h) + Smad3(h) <==> TCF-4(h):Smad3(h) (binding)
foxl2(m) + Smad3(h) <==> foxl2(m):Smad3(h) (binding)
Smad3(h) --> TNC(h) (DNA binding).
Smad3(h) + mkl1(ca) <==> Smad3(h):mkl1(ca) (binding)
Smad3(h) + mkl2(ca) <==> Smad3(h):mkl2(ca) (binding)
Smad3(h) --> c-myc(h) (DNA binding).
SMAD3(h) --> Smad3(h) (expression).
Smad3(h) --> Smad3(h) (translocation)
Sox9(r) + Smad3(h) <==> Sox9(r):Smad3(h) (binding)
c-Myc(h) + Smad3(h) <==> c-Myc(h):Smad3(h) (binding)
c-Myc(m.s.) + Smad3(h) <==> c-Myc(m.s.):Smad3(h) (binding)
Smad3(h) + p53(h) <==> Smad3(h):p53(h) (binding)
Smad3(h) --> alpha-actin-2(m) (increase of promoter activity)
Smad3(h) --> collagen-IIalpha1(h) (increase of abundance)
Smad3(h) + axin(r) <==> Smad3(h):axin(r) (binding)
Smad3(h) + 3 ATP --Cdk4(h)--> Smad3(h){pT8}{pT178}{pS212} + 3 ADP (phosphorylation)
Smad3(h) + 3 ATP --Cdk2(h)--> Smad3(h){pT8}{pT178}{pS212} + 3 ADP (phosphorylation)
Smad3(h) + 3 ATP --ERK(h)--> Smad3(h){pT178}{pS203}{pS207} + 3 ADP (phosphorylation)
Smad3(h) + ATP --> Smad3(h){p} + ADP (phosphorylation)
DACH1(h) + Smad3(h) <==> DACH1(h):Smad3(h) (binding)
Smad3(h) + c-Ski(h) <==> Smad3(h):c-Ski(h) (binding)
Smad3(h) + PML(h) <==> Smad3(h):PML(h) (binding)
PML(h) + Smad3(h) + SARA(m.s.) <==> PML(h):Smad3(h):SARA(m.s.) (binding)
Dab2(h) + Smad3(h) <==> Dab2(h):Smad3(h) (binding)
Cdc25A(h) + Smad3(h) <==> Cdc25A(h):Smad3(h) (binding)
Smad3(h) + ATP --> Smad3(h){pS} + ADP (phosphorylation)
p300(h) + Smad3(h) <==> p300(h):Smad3(h) (binding)
Smad3(h) + PDK1(h) <==> Smad3(h):PDK1(h) (binding)
Smad3(h) + ATP --PDK1(h)--> Smad3(h){p} + ADP (phosphorylation)
Smad3(h) --> TGFB2(h) (DNA binding).
brca1(h) + Smad3(h) <==> brca1(h):Smad3(h) (binding)
Smad3(h) --> SERPINE1(h) (DNA binding).
Smad3(h) --> FBLN5(h) (DNA binding).
Smad3(h) --> Gast(m) (DNA binding).
pax6(m.s.) + Smad3(h) <==> pax6(m.s.):Smad3(h) (binding)
Smad3(h) --> ELN(h) (DNA binding).
ER-alpha(h) + Smad3(h) <==> ER-alpha(h):Smad3(h) (binding)
Smad3(h) --> SMAD7(h) (DNA binding).
Smad3(h) --> TERT(h) (DNA binding).
Smad3(h) --> MMP13(h) (DNA binding).
Smad3(h) --/ SEPP1(h) (DNA binding; transrepression).
Smad3(h) --> ACTA2(h) (DNA binding).
Smad3(h) --> IgH(m) (DNA binding).
Smad3(h) --> c-myc(h) (DNA binding).
SMAD3(h) --> Smad3(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

423Phosphoserine (By similarity).Swiss-Prot 53.0
425Phosphoserine (By similarity).Swiss-Prot 53.0
422Phosphoserine (MAP3K7)9380693Phospho.ELM 6.0
423Phosphoserine (MAP3K7)9380693Phospho.ELM 6.0
425Phosphoserine (MAP3K7)9380693Phospho.ELM 6.0
8Phosphothreonine (CDK2;CDK4)15241418;15520018Phospho.ELM 6.0
213Phosphoserine (CDK2;CDK4)15241418;15520018;10197981Phospho.ELM 6.0
179Phosphothreonine (CDK2;CDK4)15241418;15520018;10197981;16156666Phospho.ELM 6.0
204Phosphoserine (MAPK1)15241418;15520018;10197981;16156666Phospho.ELM 6.0
208Phosphoserine (MAPK1)15241418;15520018;10197981;16156666Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr15

 Promoter: 65143749 - 65145749Agilent_014791

chr15

 Promoter: 65143749 - 65145749GSE27584

chr15

 Promoter: 65143749 - 65145749Agilent_014791_44K

chr15

 Promoter: 65143749 - 65145749Agilent_014791

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