| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 468 |
Name | ATF4 |
Synonym | CREB-2|CREB2|TAXREB67|TXREB;activating transcription factor 4 (tax-responsive enhancer element B67);ATF4;activating transcription factor 4 (tax-responsive enhancer element B67) |
Definition | DNA-binding protein TAXREB67|cAMP response element-binding protein 2|cAMP-dependent transcription factor ATF-4|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-4|cyclic AMP-responsive element-binding protein 2|tax-re |
Position | 22q13.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "Several ER stress/UPR genes, including Immunoglobulin-heavy-chain binding protein (BiP), Activating Transcription Factor-4 and -6 (ATF4 and ATF6) and a spliced form of X-box binding protein (XBP1) were upregulated in lcSSc PBMCs, with the highest levels in patients with PAH. TG upregulated Heat shock proteins (HSP) and Interferon-regulated genes in control PBMCs. Selected HSP genes, particularly DNAJB1, and IFN-related genes were also found at significantly elevated levels in PBMCs from lcSSc patients, while IRF4 was significantly decreased. There was a positive correlation between DNAJB1 and severity of PAH disease (PAP) (r = 0.56, p<0.05) and between ER stress markers and IL-6 levels (r = 0.53, p< 0.0001) in lcSSc PBMCs." |
| More detail of all Human literatures about ATF4 | |
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Pathways and Diseases |
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Pathway | Neurotrophin signaling pathway;KEGG PATHWAY;hsa04722 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | PERK regulated gene expression;PID Reactome;500132 |
Pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2;PID Curated;200044 |
Pathway | Protein processing in endoplasmic reticulum;KEGG PATHWAY;hsa04141 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Disease | Embryoma;FunDO |
Disease | Bipolar disorder;FunDO |
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External Links |
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Links to Entrez Gene | 468 |
Links to all GeneRIF Items | 468 |
Links to iHOP | 468 |
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Sequence Information |
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Nucleotide Sequence |
>468 : length: 1056 atgaccgaaatgagcttcctgagcagcgaggtgttggtgggggacttgatgtcccccttc gaccagtcgggtttgggggctgaagaaagcctaggtctcttagatgattacctggaggtg gccaagcacttcaaacctcatgggttctccagcgacaaggctaaggcgggctcctccgaa tggctggctgtggatgggttggtcagtccctccaacaacagcaaggaggatgccttctcc gggacagattggatgttggagaaaatggatttgaaggagttcgacttggatgccctgttg ggtatagatgacctggaaaccatgccagatgaccttctgaccacgttggatgacacttgt gatctctttgcccccctagtccaggagactaataagcagcccccccagacggtgaaccca attggccatctcccagaaagtttaacaaaacccgaccaggttgcccccttcaccttctta caacctcttcccctttccccaggggtcctgtcctccactccagatcattcctttagttta gagctgggcagtgaagtggatatcactgaaggagataggaagccagactacactgcttac gttgccatgatccctcagtgcataaaggaggaagacaccccttcagataatgatagtggc atctgtatgagcccagagtcctatctggggtctcctcagcacagcccctctaccaggggc tctccaaataggagcctcccatctccaggtgttctctgtgggtctgcccgtcccaaacct tacgatcctcctggagagaagatggtagcagcaaaagtaaagggtgagaaactggataag aagctgaaaaaaatggagcaaaacaagacagcagccactaggtaccgccagaagaagagg gcggagcaggaggctcttactggtgagtgcaaagagctggaaaagaagaacgaggctcta aaagagagggcggattccctggccaaggagatccagtacctgaaagatttgatagaagag gtccgcaaggcaagggggaagaaaagggtcccctag |
Protein Sequence |
>468 : length: 351 MTEMSFLSSEVLVGDLMSPFDQSGLGAEESLGLLDDYLEVAKHFKPHGFSSDKAKAGSSE WLAVDGLVSPSNNSKEDAFSGTDWMLEKMDLKEFDLDALLGIDDLETMPDDLLTTLDDTC DLFAPLVQETNKQPPQTVNPIGHLPESLTKPDQVAPFTFLQPLPLSPGVLSSTPDHSFSL ELGSEVDITEGDRKPDYTAYVAMIPQCIKEEDTPSDNDSGICMSPESYLGSPQHSPSTRG SPNRSLPSPGVLCGSARPKPYDPPGEKMVAAKVKGEKLDKKLKKMEQNKTAATRYRQKKR AEQEALTGECKELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP |