| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 468 |
Name | ATF4 |
Synonymous | CREB-2|CREB2|TAXREB67|TXREB;activating transcription factor 4 (tax-responsive enhancer element B67);ATF4;activating transcription factor 4 (tax-responsive enhancer element B67) |
Definition | DNA-binding protein TAXREB67|cAMP response element-binding protein 2|cAMP-dependent transcription factor ATF-4|cAMP-responsive element-binding protein 2|cyclic AMP-dependent transcription factor ATF-4|cyclic AMP-responsive element-binding protein 2|tax-re |
Position | 22q13.1 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for ATF4 | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
ATF-4(h) + ATF-4(h) <==> ATF-4(h):ATF-4(h) (binding). | C/EBPbeta(p35)(m) + ATF-4(h) <==> C/EBPbeta(p35)(m):ATF-4(h) (binding). | C/EBPalpha(m) + ATF-4(h) <==> C/EBPalpha(m):ATF-4(h) (binding). | C/EBPalpha(h) + ATF-4(h) <==> C/EBPalpha(h):ATF-4(h) (binding). | C/EBPalpha(r) + ATF-4(h) <==> C/EBPalpha(r):ATF-4(h) (binding). | c-Fos(m) + ATF-4(h) <==> c-Fos(m):ATF-4(h) (binding). | c-Fos(h) + ATF-4(h) <==> c-Fos(h):ATF-4(h) (binding). | c-Fos(r) + ATF-4(h) <==> c-Fos(r):ATF-4(h) (binding). | c-Fos(c) + ATF-4(h) <==> c-Fos(c):ATF-4(h) (binding). | c-Jun(m) + ATF-4(h) <==> c-Jun(m):ATF-4(h) (binding). | c-Jun(r) + ATF-4(h) <==> c-Jun(r):ATF-4(h) (binding). | ATF-4(h) + c-Jun(h) <==> ATF-4(h):c-Jun(h) (binding). | c-Jun(HA) + ATF-4(h) <==> c-Jun(HA):ATF-4(h) (binding). | cebpe(r) + ATF-4(h) <==> cebpe(r):ATF-4(h) (binding). | C/EBPgamma(m) + ATF-4(h) <==> C/EBPgamma(m):ATF-4(h) (binding). | Fra-1(m) + ATF-4(h) <==> Fra-1(m):ATF-4(h) (binding). | C/EBPbeta(LAP)(r) + ATF-4(h) <==> C/EBPbeta(LAP)(r):ATF-4(h) (binding). | C/EBPbeta(h) + ATF-4(h) <==> C/EBPbeta(h):ATF-4(h) (binding). | Fra-1(r) + ATF-4(h) <==> Fra-1(r):ATF-4(h) (binding). | LANA(KSHV) + ATF-4(h) <==> LANA(KSHV):ATF-4(h) (binding). | ATF-4(h) + GPS2(h) <==> ATF-4(h):GPS2(h) (binding) | ATF-4(h) + TBPA(h) <==> ATF-4(h):TBPA(h) (binding) | ATF-4(h) + TREX2(h) <==> ATF-4(h):TREX2(h) (binding) | ATF-4(h) + BCUR1(h) <==> ATF-4(h):BCUR1(h) (binding) | ATF-4(h) + TRG-15(h) <==> ATF-4(h):TRG-15(h) (binding) | ATF-4(h) + ATP --RSK2(m)--> ATF-4(h){pS245} + ADP (phosphorylation) | ATF4(h) --> ATF-4(h) (expression). | ATF-4(h) --> Sst(r) (DNA binding). | ATF-4(h) --> TCR-alpha(h) (DNA binding; transregulation). | C/EBPalpha(h) + ATF-4(h) <==> C/EBPalpha(h):ATF-4(h) (binding) | NF-IL6-1(h) + ATF-4(h) <==> NF-IL6-1(h):ATF-4(h) (binding) | C/EBPgamma(h) + ATF-4(h) <==> C/EBPgamma(h):ATF-4(h) (binding) | C/EBPdelta(h) + ATF-4(h) <==> C/EBPdelta(h):ATF-4(h) (binding) | cebpe(h) + ATF-4(h) <==> cebpe(h):ATF-4(h) (binding) | CHOP-10(h) + ATF-4(h) <==> CHOP-10(h):ATF-4(h) (binding) | ATF-4(h) + Zhangfei(h) <==> ATF-4(h):Zhangfei(h) (binding) | ATFa-isoform3(h) + ATF-4(h) <==> ATFa-isoform3(h):ATF-4(h) (binding) | CREBPA-Alpha(h) + ATF-4(h) <==> CREBPA-Alpha(h):ATF-4(h) (binding) | c-Fos(h) + ATF-4(h) <==> c-Fos(h):ATF-4(h) (binding) | ATF-4(h) + FosB(h) <==> ATF-4(h):FosB(h) (binding) | ATF-3(h) + ATF-4(h) <==> ATF-3(h):ATF-4(h) (binding) | B-ATF(h) + ATF-4(h) <==> B-ATF(h):ATF-4(h) (binding) | ATF-4(h) + batf3(h) <==> ATF-4(h):batf3(h) (binding) | ATF-4(h) + Hlf(h) <==> ATF-4(h):Hlf(h) (binding) | ATF-4(h) + c-MAF-isoform2(h) <==> ATF-4(h):c-MAF-isoform2(h) (binding) | ATF-4(h) + Nfe2l1-xbb1(h) <==> ATF-4(h):Nfe2l1-xbb1(h) (binding) | ATF-4(h) --> Bglap2(m) (DNA binding). | ATF-4(h) --> Pdgfra(m) (DNA binding; transactivation). | ATF4(h) --> ATF-4(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
219 | Phosphoserine | 11238952 | Phospho.ELM 6.0 | 245 | Phosphoserine (RSK-2) | 15109498 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr22 |
Promoter: 38245015 - 38247015 | Agilent_014791 |
chr22 |
Promoter: 38245015 - 38247015 | GSE27584 |
chr22 |
Promoter: 38245015 - 38247015 | GSE27584 |
chr22 |
Promoter: 38245015 - 38247015 | Agilent_014791_44K |