| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 4773 |
Name | NFATC2 |
Synonym | NFAT1|NFATP;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2;NFATC2;nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 |
Definition | NF-ATc2|NFAT pre-existing subunit|NFAT transcription complex, preexisting component|T cell transcription factor NFAT1|T-cell transcription factor NFAT1|nuclear factor of activated T-cells, cytoplasmic 2|nuclear factor of activated T-cells, preexisting com |
Position | 20q13.2 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | "Heightened expression of the transcription factor nuclear factor of activated T cells c2 (NFATc2), which is associated with activated inflammatory cells, may underlie PAH." |
PH | The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted. |
| More detail of all Human literatures about NFATC2 | |
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Pathways and Diseases |
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Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | Axon guidance mediated by netrin;PANTHER;P00009 |
Pathway | B cell receptor signaling pathway;KEGG PATHWAY;hsa04662 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | T cell receptor signaling pathway;KEGG PATHWAY;hsa04660 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | Downstream signaling in naive CD8+ T cells;PID Curated;200184 |
Pathway | Axon guidance;KEGG PATHWAY;hsa04360 |
Pathway | Noncanonical Wnt signaling pathway;PID Curated;200016 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | Fc-epsilon receptor I signaling in mast cells;PID Curated;200003 |
Pathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes;PID Curated;200039 |
Pathway | T cell activation;PANTHER;P00053 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Pathway | B cell activation;PANTHER;P00010 |
Pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2;PID Curated;200044 |
Disease | Colon cancer;FunDO |
Disease | Breast cancer;FunDO |
Disease | Aplastic anemia;FunDO |
Disease | Leukoencephalopathy;FunDO |
Disease | Lymphoma;FunDO |
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External Links |
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Links to Entrez Gene | 4773 |
Links to all GeneRIF Items | 4773 |
Links to iHOP | 4773 |
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Sequence Information |
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Nucleotide Sequence |
>4773 : length: 2706 atgcagagagaggctgcgttcagactggggcactgccatcccctccgcatcatggggtct gtggaccaagaagagccgaatgcacataaggtcgccagcccaccctccggacccgcatac cccgatgatgtcctggactatggcctcaagccatacagcccccttgctagtctctctggc gagccccccggccgattcggagagccggatagggtagggccgcagaagtttctgagcgcg gccaagccagcaggggcctcgggcctgagccctcggatcgagatcactccgtcccacgaa ctgatccaggcagtggggcccctccgcatgagagacgcgggcctcctggtggagcagccg cccctggccggggtggccgccagcccgaggttcaccctgcccgtgcccggcttcgagggc taccgcgagccgctttgcttgagccccgctagcagcggctcctctgccagcttcatttct gacaccttctccccctacacctcgccctgcgtctcgcccaataacggcgggcccgacgac ctgtgtccgcagtttcaaaacatccctgctcattattcccccagaacctcgccaataatg tcacctcgaaccagcctcgccgaggacagctgcctgggccgccactcgcccgtgccccgt ccggcctcccgctcctcatcgcctggtgccaagcggaggcattcgtgcgccgaggccttg gttgccctgccgcccggagcctcaccccagcgctcccggagcccctcgccgcagccctca tctcacgtggcaccccaggaccacggctccccggctgggtacccccctgtggctggctct gccgtgatcatggatgccctgaacagcctcgccacggactcgccttgtgggatccccccc aagatgtggaagaccagccctgacccctcgccggtgtctgccgccccatccaaggccggc ctgcctcgccacatctacccggccgtggagttcctggggccctgcgagcagggcgagagg agaaactcggctccagaatccatcctgctggttccgcccacttggcccaagccgctggtg cctgccattcccatctgcagcatcccagtgactgcatccctccctccacttgagtggccg ctgtccagtcagtcaggctcttacgagctgcggatcgaggtgcagcccaagccacatcac cgggcccactatgagacagaaggcagccgaggggctgtcaaagctccaactggaggccac cctgtggttcagctccatggctacatggaaaacaagcctctgggacttcagatcttcatt gggacagctgatgagcggatccttaagccgcacgccttctaccaggtgcaccgaatcacg gggaaaactgtcaccaccaccagctatgagaagatagtgggcaacaccaaagtcctggag atacccttggagcccaaaaacaacatgagggcaaccatcgactgtgcggggatcttgaag cttagaaacgccgacattgagctgcggaaaggcgagacggacattggaagaaagaacacg cgggtgagactggttttccgagttcacatcccagagtccagtggcagaatcgtctcttta cagactgcatctaaccccatcgagtgctcccagcgatctgctcacgagctgcccatggtt gaaagacaagacacagacagctgcctggtctatggcggccagcaaatgatcctcacgggg cagaactttacatccgagtccaaagttgtgtttactgagaagaccacagatggacagcaa atttgggagatggaagccacggtggataaggacaagagccagcccaacatgctttttgtt gagatccctgaatatcggaacaagcatatccgcacacctgtaaaagtgaacttctacgtc atcaatgggaagagaaaacgaagtcagcctcagcactttacctaccacccagtcccagcc atcaagacggagcccacggatgaatatgaccccactctgatctgcagccccacccatgga ggcctggggagccagccttactacccccagcacccgatggtggccgagtccccctcctgc ctcgtggccaccatggctccctgccagcagttccgcacggggctctcatcccctgacgcc cgctaccagcaacagaacccagcggccgtactctaccagcggagcaagagcctgagcccc agcctgctgggctatcagcagccggccctcatggccgccccgctgtcccttgcggacgct caccgctctgtgctggtgcacgccggctcccagggccagagctcagccctgctccacccc tctccgaccaaccagcaggcctcgcctgtgatccactactcacccaccaaccagcagctg cgctgcggaagccaccaggagttccagcacatcatgtactgcgagaatttcgcaccaggc accaccagacctggcccgcccccggtcagtcaaggtcagaggctgagcccgggttcctac cccacagtcattcagcagcagaatgccacgagccaaagagccgccaaaaacggacccccg gtcagtgaccaaaaggaagtattacctgcgggggtgaccattaaacaggagcagaacttg gaccagacctacttggatgatgagctgatagacacacaccttagctggatacaaaacata ttatga |
Protein Sequence |
>4773 : length: 901 MQREAAFRLGHCHPLRIMGSVDQEEPNAHKVASPPSGPAYPDDVLDYGLKPYSPLASLSG EPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQP PLAGVAASPRFTLPVPGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDD LCPQFQNIPAHYSPRTSPIMSPRTSLAEDSCLGRHSPVPRPASRSSSPGAKRRHSCAEAL VALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALNSLATDSPCGIPP KMWKTSPDPSPVSAAPSKAGLPRHIYPAVEFLGPCEQGERRNSAPESILLVPPTWPKPLV PAIPICSIPVTASLPPLEWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGH PVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVHRITGKTVTTTSYEKIVGNTKVLE IPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSL QTASNPIECSQRSAHELPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQ IWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKVNFYVINGKRKRSQPQHFTYHPVPA IKTEPTDEYDPTLICSPTHGGLGSQPYYPQHPMVAESPSCLVATMAPCQQFRTGLSSPDA RYQQQNPAAVLYQRSKSLSPSLLGYQQPALMAAPLSLADAHRSVLVHAGSQGQSSALLHP SPTNQQASPVIHYSPTNQQLRCGSHQEFQHIMYCENFAPGTTRPGPPPVSQGQRLSPGSY PTVIQQQNATSQRAAKNGPPVSDQKEVLPAGVTIKQEQNLDQTYLDDELIDTHLSWIQNI L |