| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 4843 |
Name | NOS2 |
Synonym | HEP-NOS|INOS|NOS|NOS2A;nitric oxide synthase 2, inducible;NOS2;nitric oxide synthase 2, inducible |
Definition | NOS type II|NOS, type II|hepatocyte NOS|inducible NO synthase|inducible NOS|nitric oxide synthase 2A (inducible, hepatocytes)|nitric oxide synthase, inducible|nitric oxide synthase, macrophage|peptidyl-cysteine S-nitrosylase NOS2 |
Position | 17q11.2-q12 |
Gene Type | protein-coding |
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PAH Type |
Description |
HPH | Pulmonary vascular iNOS induction participates in the onset of chronic hypoxic pulmonary hypertension. |
PAH | Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase. |
PAH | NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity. |
PAH | Nitric oxide synthases in infants and children with pulmonary hypertension and congenital heart disease. |
PH | Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice. |
PH | [Transforming growth factor beta1 correlates inducible nitric oxide synthase in pulmonary arteries of rats with hypoxia-induced pulmonary hypertension]. |
PH | Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase. |
PH | NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity. |
PH | "A novel inhibitor of inducible nitric oxide synthase, ONO-1714, does not ameliorate hypoxia-induced pulmonary hypertension in rats." |
PH | "Cellular expression of renal, cardiac and pulmonary inducible nitric oxide synthase in double-transgenic mice expressing human renin and angiotensinogen genes." |
| More detail of all Rat literatures about NOS2 | |
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Pathways and Diseases |
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Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | superpathway of citrulline metabolism;BioCyc;PWY-5004 |
Pathway | no2-dependent il-12 pathway in nk cells;PID BioCarta;100093 |
Pathway | Small cell lung cancer;KEGG PATHWAY;hsa05222 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Arginine and proline metabolism;KEGG PATHWAY;hsa00330 |
Pathway | IL23-mediated signaling events;PID Curated;200131 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | ATF-2 transcription factor network;PID Curated;200116 |
Pathway | Signaling mediated by p38-alpha and p38-beta;PID Curated;200154 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Peroxisome;KEGG PATHWAY;hsa04146 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | IL12-mediated signaling events;PID Curated;200034 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | citrulline-nitric oxide cycle;BioCyc;PWY-4983 |
Disease | atopy;GAD |
Disease | asthma atopy;GAD |
Disease | preterm delivery;GAD |
Disease | malaria, plasmodium falciparum;GAD |
Disease | Type 2 Diabetes (Retinopathy);GAD |
Disease | bladder cancer;GAD |
Disease | cirrhosis;GAD |
Disease | Essential Hypertension;GAD |
Disease | hypertension;GAD |
Disease | Dementia;GAD |
Disease | atherosclerosis, coronary;GAD |
Disease | IMMUNE;GAD |
Disease | Parkinson's disease;GAD |
Disease | Asthma;GAD |
Disease | METABOLIC;GAD |
Disease | Cancers of the digestive system;KEGG DISEASE |
Disease | rheumatoid arthritis;GAD |
Disease | retinopathy, diabetic;GAD |
Disease | INFECTION;GAD |
Disease | systemic lupus erythematosus;GAD |
Disease | tuberculosis;GAD |
Disease | diabetes, type 2;GAD |
Disease | diabetes, type 1;GAD |
Disease | REPRODUCTION;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | CANCER;GAD |
Disease | malaria;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | nephropathy, diabetic;GAD |
Disease | Cancers;KEGG DISEASE |
Disease | Hypertension, susceptibility to;OMIM |
Disease | Malaria, resistance to;OMIM |
Disease | microalbuminuria, diabetic;GAD |
Disease | Esophageal cancer;KEGG DISEASE;H00017 |
Disease | neuropathy, diabetic;GAD |
Disease | purpura, Henoch-Schonlein;GAD |
Disease | increased nitric oxide production and protection from malaria;GAD |
Disease | stomach cancer;GAD |
Disease | RENAL;GAD |
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External Links |
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Links to Entrez Gene | 4843 |
Links to all GeneRIF Items | 4843 |
Links to iHOP | 4843 |
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Sequence Information |
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Nucleotide Sequence |
>4843 : length: 3462 atggcctgtccttggaaatttctgttcaagaccaaattccaccagtatgcaatgaatggg gaaaaagacatcaacaacaatgtggagaaagccccctgtgccacctccagtccagtgaca caggatgaccttcagtatcacaacctcagcaagcagcagaatgagtccccgcagcccctc gtggagacgggaaagaagtctccagaatctctggtcaagctggatgcaaccccattgtcc tccccacggcatgtgaggatcaaaaactggggcagcgggatgactttccaagacacactt caccataaggccaaagggattttaacttgcaggtccaaatcttgcctggggtccattatg actcccaaaagtttgaccagaggacccagggacaagcctacccctccagatgagcttcta cctcaagctatcgaatttgtcaaccaatattacggctccttcaaagaggcaaaaatagag gaacatctggccagggtggaagcggtaacaaaggagatagaaacaacaggaacctaccaa ctgacgggagatgagctcatcttcgccaccaagcaggcctggcgcaatgccccacgctgc attgggaggatccagtggtccaacctgcaggtcttcgatgcccgcagctgttccactgcc cgggaaatgtttgaacacatctgcagacacgtgcgttactccaccaacaatggcaacatc aggtcggccatcaccgtgttcccccagcggagtgatggcaagcacgacttccgggtgtgg aatgctcagctcatccgctatgctggctaccagatgccagatggcagcatcagaggggac cctgccaacgtggaattcactcagctgtgcatcgacctgggctggaagcccaagtacggc cgcttcgatgtggtccccctggtcctgcaggccaatggccgtgaccctgagctcttcgaa atcccacctgaccttgtgcttgaggtggccatggaacatcccaaatacgagtggtttcgg gaactggagctaaagtggtacgccctgcctgcagtggccaacatgctgcttgaggtgggc ggcctggagttcccagggtgccccttcaatggctggtacatgggcacagagatcggagtc cgggacttctgtgacgtccagcgctacaacatcctggaggaagtgggcaggagaatgggc ctggaaacgcacaagctggcctcgctctggaaagaccaggctgtcgttgagatcaacatt gctgtgctccatagtttccagaagcagaatgtgaccatcatggaccaccactcggctgca gaatccttcatgaagtacatgcagaatgaataccggtcccgtgggggctgcccggcagac tggatttggctggtccctcccatgtctgggagcatcacccccgtgtttcaccaggagatg ctgaactacgtcctgtcccctttctactactatcaggtagaggcctggaaaacccatgtc tggcaggacgagaagcggagacccaagagaagagagattccattgaaagtcttggtcaaa gctgtgctctttgcctgtatgctgatgcgcaagacaatggcgtcccgagtcagagtcacc atcctctttgcgacagagacaggaaaatcagaggcgctggcctgggacctgggggcctta ttcagctgtgccttcaaccccaaggttgtctgcatggataagtacaggctgagctgcctg gaggaggaacggctgctgttggtggtgaccagtacgtttggcaatggagactgccctggc aatggagagaaactgaagaaatcgctcttcatgctgaaagagctcaacaacaaattcagg tacgctgtgtttggcctcggctccagcatgtaccctcggttctgcgcctttgctcatgac attgatcagaagctgtcccacctgggggcctctcagctcaccccgatgggagaaggggat gagctcagtgggcaggaggacgccttccgcagctgggccgtgcaaaccttcaaggcagcc tgtgagacgtttgatgtccgaggcaaacagcacattcagatccccaagctctacacctcc aatgtgacctgggacccgcaccactacaggctcgtgcaggactcacagcctttggacctc agcaaagccctcagcagcatgcatgccaagaacgtgttcaccatgaggctcaaatctcgg cagaatctacaaagtccgacatccagccgtgccaccatcctggtggaactctcctgtgag gatggccaaggcctgaactacctgccgggggagcaccttggggtttgcccaggcaaccag ccggccctggtccaaggtatcctggagcgagtggtggatggccccacaccccaccagaca gtgcgcctggaggccctggatgagagtggcagctactgggtcagtgacaagaggctgccc ccctgctcactcagccaggccctcacctacttcctggacatcaccacacccccaacccag ctgctgctccaaaagctggcccaggtggccacagaagagcctgagagacagaggctggag gccctgtgccagccctcagagtacagcaagtggaagttcaccaacagccccacattcctg gaggtgctagaggagttcccgtccctgcgggtgtctgctggcttcctgctttcccagctc cccattctgaagcccaggttctactccatcagctcctcccgggatcacacgcccacagag atccacctgactgtggccgtggtcacctaccacacccgagatggccagggtcccctgcac cacggcgtctgcagcacatggctcaacagcctgaagccccaagacccagtgccctgcttt gtgcggaatgccagcggcttccacctccccgaggatccctcccatccttgcatcctcatc gggcctggcacaggcatcgcgcccttccgcagtttctggcagcaacggctccatgactcc cagcacaagggagtgcggggaggccgcatgaccttggtgtttgggtgccgccgcccagat gaggaccacatctaccaggaggagatgctggagatggcccagaagggggtgctgcatgcg gtgcacacagcctattcccgcctgcctggcaagcccaaggtctatgttcaggacatcctg cggcagcagctggccagcgaggtgctccgtgtgctccacaaggagccaggccacctctat gtttgcggggatgtgcgcatggcccgggacgtggcccacaccctgaagcagctggtggct gccaagctgaaattgaatgaggagcaggtcgaggactatttctttcagctcaagagccag aagcgctatcacgaagatatctttggtgctgtatttccttacgaggcgaagaaggacagg gtggcggtgcagcccagcagcctggagatgtcagcgctctga |
Protein Sequence |
>4843 : length: 1153 MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPL VETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIM TPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQ LTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNI RSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYG RFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVG GLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINI AVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEM LNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVT ILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPG NGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGD ELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDL SKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQ PALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQ LLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQL PILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCF VRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPD EDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLY VCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDR VAVQPSSLEMSAL |