| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 4843 |
Name | NOS2 |
Synonymous | HEP-NOS|INOS|NOS|NOS2A;nitric oxide synthase 2, inducible;NOS2;nitric oxide synthase 2, inducible |
Definition | NOS type II|NOS, type II|hepatocyte NOS|inducible NO synthase|inducible NOS|nitric oxide synthase 2A (inducible, hepatocytes)|nitric oxide synthase, inducible|nitric oxide synthase, macrophage|peptidyl-cysteine S-nitrosylase NOS2 |
Position | 17q11.2-q12 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr17:26083792-26127525 | chr17:26104511-26104511 | rs11080344 | Single_Nucleotides|eQTL|SUPT6H, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|FAIRE|Urotsa, Chromatin_Structure|DNase-seq|Gm19240, Chromatin_Structure|DNase-seq|Gm12864, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|DNase-seq|Hee | chr17:26083792-26127525 | chr17:26121921-26121921 | rs3794766 | Single_Nucleotides|eQTL|PIGS, Motifs|PWM|Ddit3::Cebpa, Motifs|PWM|CHOP:C/EBPalpha, Motifs|Footprinting|Ddit3::Cebpa, Motifs|Footprinting|Ddit3::Cebpa, Motifs|Footprinting|Ddit3::Cebpa, Motifs|Footprinting|Ddit3::Cebpa, Motifs|Footprinting|CHOP:C/EBPalpha, Motifs|Footprinting|CHOP:C/EBPalpha, Motifs|Footprinting|CHOP:C/EBPalpha, Motifs|Footprinting|CHOP:C/EBPalpha, Motifs|Footprinting|CHOP:C/EBPalpha, Motifs|Footprinting|Ddit3::Cebpa, Motifs|Footprinting|CHOP:C/EBPalpha, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|DNase-seq|Hepg2, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Huh7, Chromatin_Structure|DNase-seq|Ips, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|DNase-seq|Osteobl, Chromatin_Structure|DNase-seq|H9es, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Caco2, Chromatin_Structure|DNase-seq|K562, Protein_Binding|ChIP-seq|HNF4A | chr17:26083792-26127525 | chr17:26124699-26124699 | rs16949 | Single_Nucleotides|eQTL|PIGS, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|Phte, Chromatin_Structure|DNase-seq|T47d, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Ips, Protein_Binding|ChIP-seq|CDX2, Protein_Binding|ChIP-seq|CDX2, Protein_Binding|ChIP-seq|HNF4A, Protein_Binding|ChIP-seq|RFX3, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|RAD21, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF |
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Transcription Factors [Top] |
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Regulation From TransFac database |
iNOS(h) + ATP --> iNOS(h){pS} + ADP (phosphorylation) | iNOS(h) + ATP --ERK1(m.s.)--> iNOS(h){pS745} + ADP (phosphorylation) | ERK1(h) + iNOS(h) <==> ERK1(h):iNOS(h) (binding) | ERK(h) + iNOS(h) <==> ERK(h):iNOS(h) (binding) | NOS2(h) --> iNOS(h) (expression). | caveolin-1(m.s.) --/ iNOS(h) (inhibition) | HCV-core-1B(HCV1B) --> iNOS(h) (increase of abundance) | EGF(m.s.) --> iNOS(h) (increase of abundance) | Caveolin-3(m.s.) --/ iNOS(h) (inhibition) | IL-17A(h) --> iNOS(h) (increase of abundance) | NOS2(h) --> iNOS-isoform1(h) (expression). | NOS2(h) --> iNOS-isoform2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
There is no record for NOS2 | |||
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr17 |
Promoter: 23151182 - 23153182 | GoldenGate_Methylation_Cancer_Panel_I |
chr17 |
Promoter: 23151182 - 23153182 | GSE27584 |