| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 5054 |
Name | SERPINE1 |
Synonym | PAI|PAI-1|PAI1|PLANH1;serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1;SERPINE1;serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
Definition | endothelial plasminogen activator inhibitor|plasminogen activator inhibitor 1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1|serpin E1 |
Position | 7q22.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Fibrinogen Aalpha Thr312Ala polymorphism is associated with chronic thromboembolic pulmonary hypertension. |
PAH | Plasminogen activator inhibitor type 1 inhibits smooth muscle cell proliferation in pulmonary arterial hypertension. |
PH | Plasminogen activator inhibitor type 1 inhibits smooth muscle cell proliferation in pulmonary arterial hypertension. |
PH | t-plasminogen activator inhibitor-1 polymorphism in idiopathic pulmonary arterial hypertension. |
| More detail of all Human literatures about SERPINE1 | |
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Pathways and Diseases |
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Pathway | Chagas disease;KEGG PATHWAY;hsa05142 |
Pathway | E2F transcription factor network;PID Curated;200027 |
Pathway | p53 pathway;PANTHER;P00059 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Dissolution of Fibrin Clot;PID Reactome;500304 |
Pathway | Direct p53 effectors;PID Curated;200101 |
Pathway | Regulation of nuclear SMAD2/3 signaling;PID Curated;200002 |
Pathway | Complement and coagulation cascades;KEGG PATHWAY;hsa04610 |
Pathway | fibrinolysis pathway;PID BioCarta;100164 |
Pathway | Blood coagulation;PANTHER;P00011 |
Pathway | HIF-2-alpha transcription factor network;PID Curated;200030 |
Pathway | platelet amyloid precursor protein pathway;PID BioCarta;100072 |
Pathway | p53 signaling pathway;KEGG PATHWAY;hsa04115 |
Pathway | HIF-1-alpha transcription factor network;PID Curated;200172 |
Pathway | Plasminogen activating cascade;PANTHER;P00050 |
Disease | Cardiovascular disease;FunDO |
Disease | coronary heart disease;GAD |
Disease | asthma, dust mite-sensitive;GAD |
Disease | Polyarthritis;FunDO |
Disease | Respiratory distress syndrome;FunDO |
Disease | DEVELOPMENTAL;GAD |
Disease | Metabolism disease;FunDO |
Disease | Influenza;FunDO |
Disease | IMMUNE;GAD |
Disease | endometriosis;GAD |
Disease | meningococcal disease;GAD |
Disease | cholesterol triglycerides;GAD |
Disease | Polycystic ovary syndrome;FunDO |
Disease | Hyperthyroidism;FunDO |
Disease | kidney dysfunction;GAD |
Disease | Colon cancer;FunDO |
Disease | Inherited thrombophilia;KEGG DISEASE;H00223 |
Disease | PSYCH;GAD |
Disease | plasmatic PAI-1 activity;GAD |
Disease | Stroke;GAD |
Disease | encephalopathy stroke;GAD |
Disease | Fibromatosis, Aggressive;GAD |
Disease | Infectious lung disease;FunDO |
Disease | pneumonia;GAD |
Disease | lumen loss, late;GAD |
Disease | coronary atherosclerosis;GAD |
Disease | myocardial infarct;GAD |
Disease | Periodontal disease;FunDO |
Disease | pregnancy loss, recurrent;GAD |
Disease | kidney disease;GAD |
Disease | Lung cancer;FunDO |
Disease | Melanoma;FunDO |
Disease | sudden cardiac death;GAD |
Disease | plasminogen activator;GAD |
Disease | Liver cancer;FunDO |
Disease | Malignant glioma;FunDO |
Disease | Intracranial Embolism;GAD |
Disease | oral cancer;GAD |
Disease | hypertension;GAD |
Disease | stroke, ischemic;GAD |
Disease | atherosclerosis, coronary;GAD |
Disease | Brain Ischemia;GAD |
Disease | cardiovascular disease;GAD |
Disease | prostate cancer;GAD |
Disease | Systemic infection;FunDO |
Disease | Plasminogen activator inhibitor, type I;OMIM |
Disease | Cerebral Infarction;GAD |
Disease | allergic disease, IgE mediated;GAD |
Disease | multiorgan failure septic shock mortality;GAD |
Disease | METABOLIC;GAD |
Disease | coagulopathy;GAD |
Disease | preeclampsia;GAD |
Disease | Hyperinsulinism;FunDO |
Disease | Crohn's disease;GAD |
Disease | hypertension, pregnancy induced;GAD |
Disease | Abortion;FunDO |
Disease | Ovarian cancer;FunDO |
Disease | chronic obstructive pulmonary disease/COPD;GAD |
Disease | thromboembolism, venous;GAD |
Disease | Hematologic diseases;KEGG DISEASE |
Disease | decreased risk of cerebrovascular mortality;GAD |
Disease | circadian variability in plasma PAI-1;GAD |
Disease | gastric ulcer;GAD |
Disease | HEMATOLOGICAL;GAD |
Disease | diabetes, gestational;GAD |
Disease | Hyperglycemia;FunDO |
Disease | Asthma;FunDO |
Disease | Esophagus cancer;FunDO |
Disease | Neoplasm metastasis;FunDO |
Disease | fibrinolytic activities;GAD |
Disease | Prostate cancer;FunDO |
Disease | Leukemia;FunDO |
Disease | Dental plaque;FunDO |
Disease | Infiltrating cancer;FunDO |
Disease | systemic lupus erythematosus;GAD |
Disease | colorectal cancer;GAD |
Disease | Coronary Artery Disease;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | cerebrovascular infart;GAD |
Disease | Glomerulonephritis;FunDO |
Disease | INFECTION;GAD |
Disease | REPRODUCTION;GAD |
Disease | breast cancer;GAD |
Disease | Obesity;FunDO |
Disease | polycystic ovary syndrome;GAD |
Disease | Thrombophilia;FunDO |
Disease | depression;GAD |
Disease | obesity;GAD |
Disease | Lupus Nephritis;GAD |
Disease | Breast cancer;FunDO |
Disease | Stomach cancer;FunDO |
Disease | antiphospholipid syndrome;GAD |
Disease | Embryoma;FunDO |
Disease | Chronic simple glaucoma;FunDO |
Disease | Circulatory system diseases;KEGG DISEASE |
Disease | Thrombosis;GAD |
Disease | VISION;GAD |
Disease | nephropathy in other diseases;GAD |
Disease | Aseptic necrosis of bone;FunDO |
Disease | Rheumatoid arthritis;FunDO |
Disease | Liver disease;FunDO |
Disease | Asthma;GAD |
Disease | periodontitis;GAD |
Disease | Pancreas cancer;FunDO |
Disease | Transcription of plasminogen activator inhibitor, modulator of;OMIM |
Disease | bone density;GAD |
Disease | Diabetes mellitus;FunDO |
Disease | lipoprotein, LDL;GAD |
Disease | albuminuria retinopathy, diabetic;GAD |
Disease | Multiple sclerosis;FunDO |
Disease | CANCER;GAD |
Disease | Myocardial Infarction;GAD |
Disease | Cerebral Arterial Diseases;GAD |
Disease | NEUROLOGICAL;GAD |
Disease | PAI-1 levels;GAD |
Disease | aneurysm, abdominal aortic;GAD |
Disease | limb deficiency anomalies;GAD |
Disease | RENAL;GAD |
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External Links |
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Links to Entrez Gene | 5054 |
Links to all GeneRIF Items | 5054 |
Links to iHOP | 5054 |
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Sequence Information |
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Nucleotide Sequence |
>5054 : length: 1209 atgcagatgtctccagccctcacctgcctagtcctgggcctggcccttgtctttggtgaa gggtctgctgtgcaccatcccccatcctacgtggcccacctggcctcagacttcggggtg agggtgtttcagcaggtggcgcaggcctccaaggaccgcaacgtggttttctcaccctat ggggtggcctcggtgttggccatgctccagctgacaacaggaggagaaacccagcagcag attcaagcagctatgggattcaagattgatgacaagggcatggcccccgccctccggcat ctgtacaaggagctcatggggccatggaacaaggatgagatcagcaccacagacgcgatc ttcgtccagcgggatctgaagctggtccagggcttcatgccccacttcttcaggctgttc cggagcacggtcaagcaagtggacttttcagaggtggagagagccagattcatcatcaat gactgggtgaagacacacacaaaaggtatgatcagcaacttgcttgggaaaggagccgtg gaccagctgacacggctggtgctggtgaatgccctctacttcaacggccagtggaagact cccttccccgactccagcacccaccgccgcctcttccacaaatcagacggcagcactgtc tctgtgcccatgatggctcagaccaacaagttcaactatactgagttcaccacgcccgat ggccattactacgacatcctggaactgccctaccacggggacaccctcagcatgttcatt gctgccccttatgaaaaagaggtgcctctctctgccctcaccaacattctgagtgcccag ctcatcagccactggaaaggcaacatgaccaggctgccccgcctcctggttctgcccaag ttctccctggagactgaagtcgacctcaggaagcccctagagaacctgggaatgaccgac atgttcagacagtttcaggctgacttcacgagtctttcagaccaagagcctctccacgtc gcgcaggcgctgcagaaagtgaagatcgaggtgaacgagagtggcacggtggcctcctca tccacagctgtcatagtctcagcccgcatggcccccgaggagatcatcatggacagaccc ttcctctttgtggtccggcacaaccccacaggaacagtccttttcatgggccaagtgatg gaaccctga |
Protein Sequence |
>5054 : length: 402 MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP |