Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5054

Name

SERPINE1

Synonymous

PAI|PAI-1|PAI1|PLANH1;serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1;SERPINE1;serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Definition

endothelial plasminogen activator inhibitor|plasminogen activator inhibitor 1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1|serpin E1

Position

7q22.1

Gene Type

protein-coding

Gene Regulation:

ENCODE RegulomeDB
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB   [Top]

Link to UCSC genome

Matched SNP location

dbSNP ID

Regulatory information

chr7:100770370-100782547chr7:100776931-100776931rs2227684Single_Nucleotides|eQTL|C7orf43, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hcfaa, Chromatin_Structure|DNase-seq|Panc1, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A
chr7:100770370-100782547chr7:100777267-100777267rs2070682Single_Nucleotides|eQTL|C7orf43, Chromatin_Structure|DNase-seq|Hre, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Aoaf, Chromatin_Structure|DNase-seq|Hac, Chromatin_Structure|DNase-seq|Hmvecdblad, Chromatin_Structure|DNase-seq|Hmvecdneo, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Hpdlf, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Be2c, Chromatin_Structure|DNase-seq|Hee, Chromatin_Structure|DNase-seq|Nha, Chromatin_Structure|DNase-seq|Sknshra, Chromatin_Structure|DNase-seq|Hffmyc, Chromatin_Structure|DNase-seq|Ag09319, Chromatin_Structure|DNase-seq|Ag09309, Chromatin_Structure|DNase-seq|Nhlf, Chromatin_Structure|DNase-seq|Skmc, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hconf, Chromatin_Structure|DNase-seq|Hvmf, Chromatin_Structure|DNase-seq|K562, Chromatin_Structure|DNase-seq|Nhdfad, Chromatin_Structure|DNase-seq|Ag04450, Chromatin_Structure|DNase-seq|Bj, Chromatin_Structure|DNase-seq|Hff, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Nb4, Chromatin_Structure|DNase-seq|Nhdfneo, Chromatin_Structure|DNase-seq|Ag10803, Chromatin_Structure|DNase-seq|Hcfaa, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|EGR1, Protein_Binding|ChIP-seq|EP300, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A
chr7:100770370-100782547chr7:100781084-100781084rs11178Single_Nucleotides|eQTL|C7orf43, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hpaf, Chromatin_Structure|DNase-seq|Caco2, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Hepg2, Chromatin_Structure|DNase-seq|Hgf, Chromatin_Structure|DNase-seq|Hmvecdlyad, Chromatin_Structure|DNase-seq|Hrpe, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hee, Chromatin_Structure|DNase-seq|Nhek, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A
chr7:100770370-100782547chr7:100781445-100781445rs7242Single_Nucleotides|eQTL|C7orf43, Motifs|PWM|EWSR1-FLI1, Chromatin_Structure|DNase-seq|Skmc, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|DNase-seq|Helas3, Chromatin_Structure|DNase-seq|Hbmec, Protein_Binding|ChIP-seq|HEY1, Protein_Binding|ChIP-seq|GATA1, Protein_Binding|ChIP-seq|SMARCA4, Protein_Binding|ChIP-seq|FOXA1
chr7:100770370-100782547chr7:100782460-100782460rs1050955Single_Nucleotides|eQTL|SERPINE1, Motifs|Footprinting|IRF, Motifs|Footprinting|IRF, Motifs|PWM|IRF, Chromatin_Structure|DNase-seq|Hae, Chromatin_Structure|DNase-seq|Ag04449, Chromatin_Structure|DNase-seq|Hee, Chromatin_Structure|DNase-seq|Panc1, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Hah, Chromatin_Structure|DNase-seq|Hcm, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Hmveclbl, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hmvecdneo, Chromatin_Structure|DNase-seq|Hcf, Chromatin_Structure|DNase-seq|Hmf, Chromatin_Structure|DNase-seq|Hmveclly, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Skmc, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Hbmec, Chromatin_Structure|DNase-seq|Hasp, Chromatin_Structure|DNase-seq|Hcfaa, Chromatin_Structure|DNase-seq|Hmvecdblad, Chromatin_Structure|DNase-seq|Hmvecdblneo, Chromatin_Structure|DNase-seq|Saec, Chromatin_Structure|DNase-seq|Hrce, Chromatin_Structure|DNase-seq|Hcpe, Chromatin_Structure|DNase-seq|Hmvecdlyad, Protein_Binding|ChIP-seq|HEY1, Protein_Binding|ChIP-seq|POLR2A

Transcription Factors   [Top]

Regulation From TransFac database

p53(h) --> PAI1(h) (increase of abundance)
SERPINE1(h) --> PAI1(h) (expression).
TGFbeta2(h) --> PAI1(h) (increase of abundance)
SERPINE1(h) --> PAI1(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

232N-linked (GlcNAc...).Swiss-Prot 53.0
288N-linked (GlcNAc...).Swiss-Prot 53.0
352N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr7

 Promoter: 100555672 - 100557672GoldenGate_Methylation_Cancer_Panel_I

chr7

 Promoter: 100555672 - 100557672GSE27584

chr7

 Promoter: 100555672 - 100557672Agilent_014791

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