Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

5154

Name

PDGFA

Synonym

PDGF-A|PDGF1;platelet-derived growth factor alpha polypeptide;PDGFA;platelet-derived growth factor alpha polypeptide

Definition

PDGF A-chain|PDGF subunit A|PDGF-1|platelet-derived growth factor A chain|platelet-derived growth factor alpha chain|platelet-derived growth factor alpha isoform 2 preproprotein|platelet-derived growth factor subunit A

Position

7p22

Gene Type

protein-coding

PAH Type

Description

PAH

PDGF receptor and its antagonists: role in treatment of PAH.
More detail of all Human literatures about PDGFA

Pathways and Diseases

Pathway

Melanoma;KEGG PATHWAY;hsa05218

Pathway

Glioma;KEGG PATHWAY;hsa05214

Pathway

Hemostasis;Reactome;REACT:604

Pathway

Gap junction;KEGG PATHWAY;hsa04540

Pathway

Focal adhesion;KEGG PATHWAY;hsa04510

Pathway

role of pi3k subunit p85 in regulation of actin organization and cell migration;PID BioCarta;100211

Pathway

Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810

Pathway

pdgf signaling pathway;PID BioCarta;100077

Pathway

MAPK signaling pathway;KEGG PATHWAY;hsa04010

Pathway

PDGF signaling pathway;PANTHER;P00047

Pathway

Prostate cancer;KEGG PATHWAY;hsa05215

Pathway

Ceramide signaling pathway;PID Curated;200100

Pathway

Angiogenesis;PANTHER;P00005

Pathway

Signaling by PDGF;Reactome;REACT:16888

Pathway

phospholipids as signalling intermediaries;PID BioCarta;100183

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Pathway

Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060

Disease

Cancers of the nervous system;KEGG DISEASE

Disease

Cancers;KEGG DISEASE

Disease

Cancers of the lung and pleura;KEGG DISEASE

Disease

Glioma;KEGG DISEASE;H00042

Disease

Cancer;FunDO

Disease

Endometriosis;FunDO

Disease

Malignant pleural mesothelioma;KEGG DISEASE;H00015

External Links

Links to Entrez Gene

5154

Links to all GeneRIF Items

5154

Links to iHOP

5154

Sequence Information

Nucleotide Sequence

>5154 : length: 636
atgaggaccttggcttgcctgctgctcctcggctgcggatacctcgcccatgttctggcc
gaggaagccgagatcccccgcgaggtgatcgagaggctggcccgcagtcagatccacagc
atccgggacctccagcgactcctggagatagactccgtagggagtgaggattctttggac
accagcctgagagctcacggggtccatgccactaagcatgtgcccgagaagcggcccctg
cccattcggaggaagagaagcatcgaggaagctgtccccgctgtctgcaagaccaggacg
gtcatttacgagattcctcggagtcaggtcgaccccacgtccgccaacttcctgatctgg
cccccgtgcgtggaggtgaaacgctgcaccggctgctgcaacacgagcagtgtcaagtgc
cagccctcccgcgtccaccaccgcagcgtcaaggtggccaaggtggaatacgtcaggaag
aagccaaaattaaaagaagtccaggtgaggttagaggagcatttggagtgcgcctgcgcg
accacaagcctgaatccggattatcgggaagaggacacgggaaggcctagggagtcaggt
aaaaaacggaaaagaaaaaggttaaaacccacctaa

Protein Sequence

>5154 : length: 211
MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLD
TSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIW
PPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACA
TTSLNPDYREEDTGRPRESGKKRKRKRLKPT



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