| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5155 |
Name | PDGFB |
Synonym | PDGF-2|PDGF2|SIS|SSV|c-sis;platelet-derived growth factor beta polypeptide;PDGFB;platelet-derived growth factor beta polypeptide |
Definition | PDGF subunit B|PDGF, B chain|becaplermin|platelet-derived growth factor 2|platelet-derived growth factor B chain|platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)|platelet-derived growth factor subunit B|plate |
Position | 22q13.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | PDGF receptor and its antagonists: role in treatment of PAH. |
| More detail of all Human literatures about PDGFB | |
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Pathways and Diseases |
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Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | transcriptional activation of dbpb from mrna;PID BioCarta;100190 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Renal cell carcinoma;KEGG PATHWAY;hsa05211 |
Disease | Cancers of the nervous system;KEGG DISEASE |
Disease | Cancers;KEGG DISEASE |
Disease | Giant-cell fibroblastoma;OMIM |
Disease | Cancers of the lung and pleura;KEGG DISEASE |
Disease | Systemic scleroderma;FunDO |
Disease | Glioma;KEGG DISEASE;H00042 |
Disease | Bone marrow disease;FunDO |
Disease | Cancer;FunDO |
Disease | Meningioma, SIS-related;OMIM |
Disease | Dermatofibrosarcoma protuberans;OMIM |
Disease | Malignant pleural mesothelioma;KEGG DISEASE;H00015 |
Disease | Atherosclerosis;FunDO |
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External Links |
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Links to Entrez Gene | 5155 |
Links to all GeneRIF Items | 5155 |
Links to iHOP | 5155 |
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Sequence Information |
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Nucleotide Sequence |
>5155 : length: 726 atgaatcgctgctgggcgctcttcctgtctctctgctgctacctgcgtctggtcagcgcc gagggggaccccattcccgaggagctttatgagatgctgagtgaccactcgatccgctcc tttgatgatctccaacgcctgctgcacggagaccccggagaggaagatggggccgagttg gacctgaacatgacccgctcccactctggaggcgagctggagagcttggctcgtggaaga aggagcctgggttccctgaccattgctgagccggccatgatcgccgagtgcaagacgcgc accgaggtgttcgagatctcccggcgcctcatagaccgcaccaacgccaacttcctggtg tggccgccctgtgtggaggtgcagcgctgctccggctgctgcaacaaccgcaacgtgcag tgccgccccacccaggtgcagctgcgacctgtccaggtgagaaagatcgagattgtgcgg aagaagccaatctttaagaaggccacggtgacgctggaagaccacctggcatgcaagtgt gagacagtggcagctgcacggcctgtgacccgaagcccggggggttcccaggagcagcga gccaaaacgccccaaactcgggtgaccattcggacggtgcgagtccgccggccccccaag ggcaagcaccggaaattcaagcacacgcatgacaagacggcactgaaggagacccttgga gcctag |
Protein Sequence |
>5155 : length: 241 MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAEL DLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLV WPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKC ETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLG A |