| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5156 |
Name | PDGFRA |
Synonym | CD140A|PDGFR-2|PDGFR2|RHEPDGFRA;platelet-derived growth factor receptor, alpha polypeptide;PDGFRA;platelet-derived growth factor receptor, alpha polypeptide |
Definition | CD140 antigen-like family member A|CD140a antigen|PDGF-R-alpha|PDGFR-alpha|PDGFRA/BCR fusion|alpha-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 2|platelet-derived growth factor receptor alpha|rearranged-in-hypereosi |
Position | 4q12 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | PDGF receptor and its antagonists: role in treatment of PAH. |
| More detail of all Human literatures about PDGFRA | |
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Pathways and Diseases |
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Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | role of pi3k subunit p85 in regulation of actin organization and cell migration;PID BioCarta;100211 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | rac1 cell motility signaling pathway;PID BioCarta;100056 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | ATF-2 transcription factor network;PID Curated;200116 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | phospholipids as signalling intermediaries;PID BioCarta;100183 |
Pathway | PDGFR-alpha signaling pathway;PID Curated;200140 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Disease | Cancers of the nervous system;KEGG DISEASE |
Disease | Height;NHGRI |
Disease | Cancers;KEGG DISEASE |
Disease | Hematological and biochemical traits;NHGRI |
Disease | Glioma;KEGG DISEASE;H00042 |
Disease | heart transplant complications;GAD |
Disease | IMMUNE;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | neural tube defects;GAD |
Disease | Asthma;GAD |
Disease | Gastrointestinal stromal tumor, somatic;OMIM |
Disease | Hypereosinophilic syndrome, idiopathic, resistant to imatinib;OMIM |
Disease | DEVELOPMENTAL;GAD |
Disease | height;GAD |
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External Links |
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Links to Entrez Gene | 5156 |
Links to all GeneRIF Items | 5156 |
Links to iHOP | 5156 |
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Sequence Information |
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Nucleotide Sequence |
>5156 : length: 3270 atggggacttcccatccggcgttcctggtcttaggctgtcttctcacagggctgagccta atcctctgccagctttcattaccctctatccttccaaatgaaaatgaaaaggttgtgcag ctgaattcatccttttctctgagatgctttggggagagtgaagtgagctggcagtacccc atgtctgaagaagagagctccgatgtggaaatcagaaatgaagaaaacaacagcggcctt tttgtgacggtcttggaagtgagcagtgcctcggcggcccacacagggttgtacacttgc tattacaaccacactcagacagaagagaatgagcttgaaggcaggcacatttacatctat gtgccagacccagatgtagcctttgtacctctaggaatgacggattatttagtcatcgtg gaggatgatgattctgccattataccttgtcgcacaactgatcccgagactcctgtaacc ttacacaacagtgagggggtggtacctgcctcctacgacagcagacagggctttaatggg accttcactgtagggccctatatctgtgaggccaccgtcaaaggaaagaagttccagacc atcccatttaatgtttatgctttaaaagcaacatcagagctggatctagaaatggaagct cttaaaaccgtgtataagtcaggggaaacgattgtggtcacctgtgctgtttttaacaat gaggtggttgaccttcaatggacttaccctggagaagtgaaaggcaaaggcatcacaatg ctggaagaaatcaaagtcccatccatcaaattggtgtacactttgacggtccccgaggcc acggtgaaagacagtggagattacgaatgtgctgcccgccaggctaccagggaggtcaaa gaaatgaagaaagtcactatttctgtccatgagaaaggtttcattgaaatcaaacccacc ttcagccagttggaagctgtcaacctgcatgaagtcaaacattttgttgtagaggtgcgg gcctacccacctcccaggatatcctggctgaaaaacaatctgactctgattgaaaatctc actgagatcaccactgatgtggaaaagattcaggaaataaggtatcgaagcaaattaaag ctgatccgtgctaaggaagaagacagtggccattatactattgtagctcaaaatgaagat gctgtgaagagctatacttttgaactgttaactcaagttccttcatccattctggacttg gtcgatgatcaccatggctcaactgggggacagacggtgaggtgcacagctgaaggcacg ccgcttcctgatattgagtggatgatatgcaaagatattaagaaatgtaataatgaaact tcctggactattttggccaacaatgtctcaaacatcatcacggagatccactcccgagac aggagtaccgtggagggccgtgtgactttcgccaaagtggaggagaccatcgccgtgcga tgcctggctaagaatctccttggagctgagaaccgagagctgaagctggtggctcccacc ctgcgttctgaactcacggtggctgctgcagtcctggtgctgttggtgattgtgatcatc tcacttattgtcctggttgtcatttggaaacagaaaccgaggtatgaaattcgctggagg gtcattgaatcaatcagcccagatggacatgaatatatttatgtggacccgatgcagctg ccttatgactcaagatgggagtttccaagagatggactagtgcttggtcgggtcttgggg tctggagcgtttgggaaggtggttgaaggaacagcctatggattaagccggtcccaacct gtcatgaaagttgcagtgaagatgctaaaacccacggccagatccagtgaaaaacaagct ctcatgtctgaactgaagataatgactcacctggggccacatttgaacattgtaaacttg ctgggagcctgcaccaagtcaggccccatttacatcatcacagagtattgcttctatgga gatttggtcaactatttgcataagaatagggatagcttcctgagccaccacccagagaag ccaaagaaagagctggatatctttggattgaaccctgctgatgaaagcacacggagctat gttattttatcttttgaaaacaatggtgactacatggacatgaagcaggctgatactaca cagtatgtccccatgctagaaaggaaagaggtttctaaatattccgacatccagagatca ctctatgatcgtccagcctcatataagaagaaatctatgttagactcagaagtcaaaaac ctcctttcagatgataactcagaaggccttactttattggatttgttgagcttcacctat caagttgcccgaggaatggagtttttggcttcaaaaaattgtgtccaccgtgatctggct gctcgcaacgtcctcctggcacaaggaaaaattgtgaagatctgtgactttggcctggcc agagacatcatgcatgattcgaactatgtgtcgaaaggcagtacctttctgcccgtgaag tggatggctcctgagagcatctttgacaacctctacaccacactgagtgatgtctggtct tatggcattctgctctgggagatcttttcccttggtggcaccccttaccccggcatgatg gtggattctactttctacaataagatcaagagtgggtaccggatggccaagcctgaccac gctaccagtgaagtctacgagatcatggtgaaatgctggaacagtgagccggagaagaga ccctccttttaccacctgagtgagattgtggagaatctgctgcctggacaatataaaaag agttatgaaaaaattcacctggacttcctgaagagtgaccatcctgctgtggcacgcatg cgtgtggactcagacaatgcatacattggtgtcacctacaaaaacgaggaagacaagctg aaggactgggagggtggtctggatgagcagagactgagcgctgacagtggctacatcatt cctctgcctgacattgaccctgtccctgaggaggaggacctgggcaagaggaacagacac agctcgcagacctctgaagagagtgccattgagacgggttccagcagttccaccttcatc aagagagaggacgagaccattgaagacatcgacatgatggatgacatcggcatagactct tcagacctggtggaagacagcttcctgtaa |
Protein Sequence |
>5156 : length: 1089 MGTSHPAFLVLGCLLTGLSLILCQLSLPSILPNENEKVVQLNSSFSLRCFGESEVSWQYP MSEEESSDVEIRNEENNSGLFVTVLEVSSASAAHTGLYTCYYNHTQTEENELEGRHIYIY VPDPDVAFVPLGMTDYLVIVEDDDSAIIPCRTTDPETPVTLHNSEGVVPASYDSRQGFNG TFTVGPYICEATVKGKKFQTIPFNVYALKATSELDLEMEALKTVYKSGETIVVTCAVFNN EVVDLQWTYPGEVKGKGITMLEEIKVPSIKLVYTLTVPEATVKDSGDYECAARQATREVK EMKKVTISVHEKGFIEIKPTFSQLEAVNLHEVKHFVVEVRAYPPPRISWLKNNLTLIENL TEITTDVEKIQEIRYRSKLKLIRAKEEDSGHYTIVAQNEDAVKSYTFELLTQVPSSILDL VDDHHGSTGGQTVRCTAEGTPLPDIEWMICKDIKKCNNETSWTILANNVSNIITEIHSRD RSTVEGRVTFAKVEETIAVRCLAKNLLGAENRELKLVAPTLRSELTVAAAVLVLLVIVII SLIVLVVIWKQKPRYEIRWRVIESISPDGHEYIYVDPMQLPYDSRWEFPRDGLVLGRVLG SGAFGKVVEGTAYGLSRSQPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNL LGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFLSHHPEKPKKELDIFGLNPADESTRSY VILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKN LLSDDNSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLA RDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMM VDSTFYNKIKSGYRMAKPDHATSEVYEIMVKCWNSEPEKRPSFYHLSEIVENLLPGQYKK SYEKIHLDFLKSDHPAVARMRVDSDNAYIGVTYKNEEDKLKDWEGGLDEQRLSADSGYII PLPDIDPVPEEEDLGKRNRHSSQTSEESAIETGSSSSTFIKREDETIEDIDMMDDIGIDS SDLVEDSFL |