| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5159 |
Name | PDGFRB |
Synonym | CD140B|IBGC4|JTK12|PDGFR|PDGFR-1|PDGFR1;platelet-derived growth factor receptor, beta polypeptide;PDGFRB;platelet-derived growth factor receptor, beta polypeptide |
Definition | CD140 antigen-like family member B|PDGF-R-beta|PDGFR-beta|beta-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 1|platelet-derived growth factor receptor beta |
Position | 5q33.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | PDGFR-beta- and EGFR-immunoreactivity of pulmonary vessels distinguishes pulmonary arterial hypertension patients from controls. |
PAH | Blockade of the PDGF tyrosine kinase receptor by imatinib had a similar effect. |
| More detail of all Human literatures about PDGFRB | |
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Pathways and Diseases |
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Pathway | Melanoma;KEGG PATHWAY;hsa05218 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | S1P1 pathway;PID Curated;200071 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | Regulation of actin cytoskeleton;KEGG PATHWAY;hsa04810 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | S1P3 pathway;PID Curated;200035 |
Pathway | Prostate cancer;KEGG PATHWAY;hsa05215 |
Pathway | Validated targets of C-MYC transcriptional repression;PID Curated;200171 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | Nectin adhesion pathway;PID Curated;200053 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Disease | Glioma;KEGG DISEASE;H00042 |
Disease | Cancers of the nervous system;KEGG DISEASE |
Disease | Myeloproliferative disorder with eosinophilia;OMIM |
Disease | Cancers;KEGG DISEASE |
Disease | Myelomonocytic leukemia, chronic;OMIM |
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External Links |
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Links to Entrez Gene | 5159 |
Links to all GeneRIF Items | 5159 |
Links to iHOP | 5159 |
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Sequence Information |
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Nucleotide Sequence |
>5159 : length: 3321 atgcggcttccgggtgcgatgccagctctggccctcaaaggcgagctgctgttgctgtct ctcctgttacttctggaaccacagatctctcagggcctggtcgtcacacccccggggcca gagcttgtcctcaatgtctccagcaccttcgttctgacctgctcgggttcagctccggtg gtgtgggaacggatgtcccaggagcccccacaggaaatggccaaggcccaggatggcacc ttctccagcgtgctcacactgaccaacctcactgggctagacacgggagaatacttttgc acccacaatgactcccgtggactggagaccgatgagcggaaacggctctacatctttgtg ccagatcccaccgtgggcttcctccctaatgatgccgaggaactattcatctttctcacg gaaataactgagatcaccattccatgccgagtaacagacccacagctggtggtgacactg cacgagaagaaaggggacgttgcactgcctgtcccctatgatcaccaacgtggcttttct ggtatctttgaggacagaagctacatctgcaaaaccaccattggggacagggaggtggat tctgatgcctactatgtctacagactccaggtgtcatccatcaacgtctctgtgaacgca gtgcagactgtggtccgccagggtgagaacatcaccctcatgtgcattgtgatcgggaat gaggtggtcaacttcgagtggacatacccccgcaaagaaagtgggcggctggtggagccg gtgactgacttcctcttggatatgccttaccacatccgctccatcctgcacatccccagt gccgagttagaagactcggggacctacacctgcaatgtgacggagagtgtgaatgaccat caggatgaaaaggccatcaacatcaccgtggttgagagcggctacgtgcggctcctggga gaggtgggcacactacaatttgctgagctgcatcggagccggacactgcaggtagtgttc gaggcctacccaccgcccactgtcctgtggttcaaagacaaccgcaccctgggcgactcc agcgctggcgaaatcgccctgtccacgcgcaacgtgtcggagacccggtatgtgtcagag ctgacactggttcgcgtgaaggtggcagaggctggccactacaccatgcgggccttccat gaggatgctgaggtccagctctccttccagctacagatcaatgtccctgtccgagtgctg gagctaagtgagagccaccctgacagtggggaacagacagtccgctgtcgtggccggggc atgccccagccgaacatcatctggtctgcctgcagagacctcaaaaggtgtccacgtgag ctgccgcccacgctgctggggaacagttccgaagaggagagccagctggagactaacgtg acgtactgggaggaggagcaggagtttgaggtggtgagcacactgcgtctgcagcacgtg gatcggccactgtcggtgcgctgcacgctgcgcaacgctgtgggccaggacacgcaggag gtcatcgtggtgccacactccttgccctttaaggtggtggtgatctcagccatcctggcc ctggtggtgctcaccatcatctcccttatcatcctcatcatgctttggcagaagaagcca cgttacgagatccgatggaaggtgattgagtctgtgagctctgacggccatgagtacatc tacgtggaccccatgcagctgccctatgactccacgtgggagctgccgcgggaccagctt gtgctgggacgcaccctcggctctggggcctttgggcaggtggtggaggccacggctcat ggcctgagccattctcaggccacgatgaaagtggccgtcaagatgcttaaatccacagcc cgcagcagtgagaagcaagcccttatgtcggagctgaagatcatgagtcaccttgggccc cacctgaacgtggtcaacctgttgggggcctgcaccaaaggaggacccatctatatcatc actgagtactgccgctacggagacctggtggactacctgcaccgcaacaaacacaccttc ctgcagcaccactccgacaagcgccgcccgcccagcgcggagctctacagcaatgctctg cccgttgggctccccctgcccagccatgtgtccttgaccggggagagcgacggtggctac atggacatgagcaaggacgagtcggtggactatgtgcccatgctggacatgaaaggagac gtcaaatatgcagacatcgagtcctccaactacatggccccttacgataactacgttccc tctgcccctgagaggacctgccgagcaactttgatcaacgagtctccagtgctaagctac atggacctcgtgggcttcagctaccaggtggccaatggcatggagtttctggcctccaag aactgcgtccacagagacctggcggctaggaacgtgctcatctgtgaaggcaagctggtc aagatctgtgactttggcctggctcgagacatcatgcgggactcgaattacatctccaaa ggcagcacctttttgcctttaaagtggatggctccggagagcatcttcaacagcctctac accaccctgagcgacgtgtggtccttcgggatcctgctctgggagatcttcaccttgggt ggcaccccttacccagagctgcccatgaacgagcagttctacaatgccatcaaacggggt taccgcatggcccagcctgcccatgcctccgacgagatctatgagatcatgcagaagtgc tgggaagagaagtttgagattcggccccccttctcccagctggtgctgcttctcgagaga ctgttgggcgaaggttacaaaaagaagtaccagcaggtggatgaggagtttctgaggagt gaccacccagccatccttcggtcccaggcccgcttgcctgggttccatggcctccgatct cccctggacaccagctccgtcctctatactgccgtgcagcccaatgagggtgacaacgac tatatcatccccctgcctgaccccaaacccgaggttgctgacgagggcccactggagggt tcccccagcctagccagctccaccctgaatgaagtcaacacctcctcaaccatctcctgt gacagccccctggagccccaggacgaaccagagccagagccccagcttgagctccaggtg gagccggagccagagctggaacagttgccggattcggggtgccctgcgcctcgggcggaa gcagaggatagcttcctgtag |
Protein Sequence |
>5159 : length: 1106 MRLPGAMPALALKGELLLLSLLLLLEPQISQGLVVTPPGPELVLNVSSTFVLTCSGSAPV VWERMSQEPPQEMAKAQDGTFSSVLTLTNLTGLDTGEYFCTHNDSRGLETDERKRLYIFV PDPTVGFLPNDAEELFIFLTEITEITIPCRVTDPQLVVTLHEKKGDVALPVPYDHQRGFS GIFEDRSYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQTVVRQGENITLMCIVIGN EVVNFEWTYPRKESGRLVEPVTDFLLDMPYHIRSILHIPSAELEDSGTYTCNVTESVNDH QDEKAINITVVESGYVRLLGEVGTLQFAELHRSRTLQVVFEAYPPPTVLWFKDNRTLGDS SAGEIALSTRNVSETRYVSELTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQINVPVRVL ELSESHPDSGEQTVRCRGRGMPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNV TYWEEEQEFEVVSTLRLQHVDRPLSVRCTLRNAVGQDTQEVIVVPHSLPFKVVVISAILA LVVLTIISLIILIMLWQKKPRYEIRWKVIESVSSDGHEYIYVDPMQLPYDSTWELPRDQL VLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLGP HLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNAL PVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADIESSNYMAPYDNYVP SAPERTCRATLINESPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLV KICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFTLG GTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLLER LLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDND YIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQDEPEPEPQLELQV EPEPELEQLPDSGCPAPRAEAEDSFL |