| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 5159 |
Name | PDGFRB |
Synonymous | CD140B|IBGC4|JTK12|PDGFR|PDGFR-1|PDGFR1;platelet-derived growth factor receptor, beta polypeptide;PDGFRB;platelet-derived growth factor receptor, beta polypeptide |
Definition | CD140 antigen-like family member B|PDGF-R-beta|PDGFR-beta|beta-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 1|platelet-derived growth factor receptor beta |
Position | 5q33.1 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr5:149493400-149535423 | chr5:149520092-149520092 | rs11738308 | Single_Nucleotides|eQTL|PDGFRB, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF | chr5:149493400-149535423 | chr5:149523176-149523176 | rs13171150 | Single_Nucleotides|eQTL|PDGFRB, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|Footprinting|Zfx, Motifs|PWM|Zfx, Chromatin_Structure|DNase-seq|A549, Chromatin_Structure|DNase-seq|Htr8, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|DNase-seq|Helas3Ifna4h, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Phte, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|DNase-seq|UrotsaUt189, Chromatin_Structure|DNase-seq|Urotsa, Chromatin_Structure|DNase-seq|Helas3, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|DNase-seq|Hepg2, Chromatin_Structure|DNase-seq|Mcf7, Chromatin_Structure|DNase-seq|Myometr, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Nhek, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Progfib, Chromatin_Structure|DNase-seq|Osteobl, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Melano, Chromatin_Structure|DNase-seq|Huh75, Chromatin_Structure|DNase-seq|Fibrobl, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|Huh7, Chromatin_Structure|DNase-seq|K562, Chromatin_Structure|DNase-seq|Panislets, Chromatin_Structure|DNase-seq|Wi38, Chromatin_Structure|FAIRE|Urotsa, Chromatin_Structure|FAIRE|UrotsaUt189, Chromatin_Structure|DNase-seq|Ips, Chromatin_Structure|DNase-seq|T47d, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|E2F6, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|EP300, Protein_Binding|ChIP-seq|USF1, Protein_Binding|ChIP-seq|GTF2F1, Protein_Binding|ChIP-seq|MAX, Protein_Binding|ChIP-seq|USF2, Protein_Binding|ChIP-seq|E2F4 | chr5:149493400-149535423 | chr5:149527844-149527844 | rs9324641 | Single_Nucleotides|eQTL|PDGFRB, Motifs|Footprinting|, Protein_Binding|ChIP-seq|SRF | chr5:149493400-149535423 | chr5:149531801-149531801 | rs4583877 | Single_Nucleotides|eQTL|PDGFRB, Motifs|Footprinting|HNF1, Motifs|PWM|HNF1, Motifs|PWM|HNF3beta, Chromatin_Structure|DNase-seq|Hrpe, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Ag10803, Chromatin_Structure|DNase-seq|Nhdfneo, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|T47d | chr5:149493400-149535423 | chr5:149532107-149532107 | rs3776081 | Single_Nucleotides|eQTL|PDGFRB, Motifs|Footprinting|C/EBP, Motifs|PWM|C/EBP, Motifs|PWM|Sox13, Motifs|Footprinting|C/EBP, Motifs|Footprinting|C/EBP, Chromatin_Structure|DNase-seq|Hepatocytes, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Sknshra | chr5:149493400-149535423 | chr5:149535255-149535255 | rs2302273 | Single_Nucleotides|eQTL|PDGFRB, Single_Nucleotides|eQTL|PDGFRB, Chromatin_Structure|DNase-seq|Gm12878, Chromatin_Structure|DNase-seq|Cll, Chromatin_Structure|DNase-seq|Gm12892, Chromatin_Structure|DNase-seq|Stellate, Chromatin_Structure|DNase-seq|Osteobl, Chromatin_Structure|DNase-seq|Medullo, Chromatin_Structure|DNase-seq|Gm19240, Chromatin_Structure|DNase-seq|Gm19238, Chromatin_Structure|DNase-seq|Gm12891, Chromatin_Structure|DNase-seq|Gm19239, Chromatin_Structure|DNase-seq|Huvec, Chromatin_Structure|DNase-seq|Hsmm, Chromatin_Structure|DNase-seq|Ips, Chromatin_Structure|DNase-seq|Hmec, Chromatin_Structure|DNase-seq|Phte, Chromatin_Structure|DNase-seq|H9es, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|K562, Chromatin_Structure|DNase-seq|UrotsaUt189, Chromatin_Structure|DNase-seq|Urotsa, Chromatin_Structure|DNase-seq|Hsmmt, Chromatin_Structure|DNase-seq|H1hesc, Chromatin_Structure|DNase-seq|Panisd, Chromatin_Structure|DNase-seq|Myometr, Chromatin_Structure|DNase-seq|Htr8, Chromatin_Structure|DNase-seq|Melano, Chromatin_Structure|DNase-seq|Hpde6e6e7, Chromatin_Structure|DNase-seq|Caco2, Chromatin_Structure|DNase-seq|Hipe, Chromatin_Structure|DNase-seq|Lncap, Chromatin_Structure|DNase-seq|Progfib, Chromatin_Structure|DNase-seq|H7es, Chromatin_Structure|DNase-seq|Hnpce, Chromatin_Structure|DNase-seq|Hre, Chromatin_Structure|FAIRE|Helas3, Chromatin_Structure|DNase-seq|Fibrop, Chromatin_Structure|DNase-seq|Gliobla, Chromatin_Structure|DNase-seq|Chorion, Chromatin_Structure|DNase-seq|Aosmc, Chromatin_Structure|DNase-seq|8988t, Chromatin_Structure|DNase-seq|Gm18507, Protein_Binding|ChIP-seq|CTCF, Protein_Binding|ChIP-seq|CTCF |
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Transcription Factors [Top] |
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Regulation From TransFac database |
2 PDGFRbeta(h) <==> PDGFRbeta(h):PDGFRbeta(h) (binding) | PDGFRbeta(h) + ATP --> PDGFRbeta(h){pY} + ADP (phosphorylation) | PDGFRbeta(h) + STAT1alpha(h) <==> PDGFRbeta(h):STAT1alpha(h) (binding) | PDGFRbeta(h) + NHERF-1(rb) <==> PDGFRbeta(h):NHERF-1(rb) (binding) | PDGFRbeta(h) + ATP --> PDGFRbeta(h){pY716} + ADP (phosphorylation; automodification) | PDGFRbeta(h) + ATP --> PDGFRbeta(h){pY775} + ADP (phosphorylation; automodification) | PDGFRbeta(h) + SHP-1(v.s.) <==> PDGFRbeta(h):SHP-1(v.s.) (binding) | PDGFRbeta(h) + p85alpha(ca) <==> PDGFRbeta(h):p85alpha(ca) (binding) | PDGFRbeta(h) + ATP --> PDGFRbeta(h){pY} + ADP (phosphorylation; automodification) | PDGFRbeta(h) + ATP --> PDGFRbeta(h){pY751} + ADP (phosphorylation) | ErbB1(h) + PDGFRbeta(h) <==> ErbB1(h):PDGFRbeta(h) (binding) | PDGFRbeta(h) + KAP4.12(h) <==> PDGFRbeta(h):KAP4.12(h) (binding) | PDGFB(h) --> PDGFRbeta(h) (activation) | PDGFRbeta(h){pY} --RPTPalpha(m)--> PDGFRbeta(h) + p (dephosphorylation) | PDGFRB(h) --> PDGFRbeta(h) (expression). | Protor-1(h) --> PDGFRbeta(h) (increase of abundance) | PDGFRbeta(h) + 2 ATP --> PDGFRbeta(h){pY}{pS} + 2 ADP (phosphorylation) | PDGFRbeta(h) + betaARK-1(b) <==> PDGFRbeta(h):betaARK-1(b) (binding) | PDGFRbeta(h) + ATP --betaARK-1(h)--> PDGFRbeta(h){pS} + ADP (phosphorylation) | PDGFRbeta(h) + ubiquitin(h) --> PDGFRbeta(h){ub} (ubiquitination) | ErbB1(h) + PDGFRbeta(h) <==> ErbB1(h):PDGFRbeta(h) (binding) | PDGFRB(h) --> PDGFRbeta(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
45 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 89 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 103 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 215 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 230 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 292 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 307 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 354 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 371 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 468 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 479 | N-linked (GlcNAc...) (Potential). | Swiss-Prot 53.0 | 751 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 857 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 579 | Phosphotyrosine (PDGFR beta) | 8195171 | Phospho.ELM 6.0 | 1009 | Phosphotyrosine (PDGFR beta) | 8195171 | Phospho.ELM 6.0 | 581 | Phosphotyrosine (PDGFR beta) | 8617789 | Phospho.ELM 6.0 | 1021 | Phosphotyrosine (PDGFR beta) | 12062403 | Phospho.ELM 6.0 | 740 | Phosphotyrosine (PDGFR beta) | 8195171 | Phospho.ELM 6.0 | 751 | Phosphotyrosine (PDGFR beta;P) | 8195171 | Phospho.ELM 6.0 | 771 | Phosphotyrosine (PDGFR beta) | 8195171 | Phospho.ELM 6.0 | 775 | Phosphotyrosine (PDGFR beta) | 8940081 | Phospho.ELM 6.0 | 857 | Phosphotyrosine (PDGFR beta;P) | 10821867;2550144 | Phospho.ELM 6.0 | 716 | Phosphotyrosine (PDGFR beta) | 8940081;7935391 | Phospho.ELM 6.0 | 778 | Phosphotyrosine (PDGFR beta) | 10821867;98055834 | Phospho.ELM 6.0 | 763 | Phosphotyrosine (PDGFR beta) | 10821867;N.N.;10391677 | Phospho.ELM 6.0 | 562 | Phosphotyrosine (PDGFR beta) | 10821867 | Phospho.ELM 6.0 | 1104 | Phosphoserine (GRK-2) | 15271984 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
There is no record for PDGFRB | ||