| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5578 |
Name | PRKCA |
Synonym | AAG6|PKC-alpha|PKCA|PRKACA;protein kinase C, alpha;PRKCA;protein kinase C, alpha |
Definition | PKC-A|aging-associated gene 6|protein kinase C alpha type |
Position | 17q22-q23.2 |
Gene Type | protein-coding |
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PAH Type |
Description |
HPH | PKC-alpha expression was elevated in rats with chronic hypoxic pulmonary hypertension. |
| More detail of all Rat literatures about PRKCA | |
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Pathways and Diseases |
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Pathway | Vascular smooth muscle contraction;KEGG PATHWAY;hsa04270 |
Pathway | Fc gamma R-mediated phagocytosis;KEGG PATHWAY;hsa04666 |
Pathway | Syndecan-4-mediated signaling events;PID Curated;200115 |
Pathway | Non-small cell lung cancer;KEGG PATHWAY;hsa05223 |
Pathway | Phosphatidylinositol signaling system;KEGG PATHWAY;hsa04070 |
Pathway | Integration of energy metabolism;Reactome;REACT:1505 |
Pathway | Vibrio cholerae infection;KEGG PATHWAY;hsa05110 |
Pathway | Signaling by GPCR;Reactome;REACT:14797 |
Pathway | VEGFR1 specific signals;PID Curated;200151 |
Pathway | MAPK signaling pathway;KEGG PATHWAY;hsa04010 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | 5HT2 type receptor mediated signaling pathway;PANTHER;P04374 |
Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway;PANTHER;P00042 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | TCR signaling in naive CD4+ T cells;PID Curated;200022 |
Pathway | Thyrotropin-releasing hormone receptor signaling pathway;PANTHER;P04394 |
Pathway | Salivary secretion;KEGG PATHWAY;hsa04970 |
Pathway | telomeres telomerase cellular aging and immortality;PID BioCarta;100021 |
Pathway | FGF signaling pathway;PANTHER;P00021 |
Pathway | ATF-2 transcription factor network;PID Curated;200116 |
Pathway | Ras signaling in the CD4+ TCR pathway;PID Curated;200088 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Wnt signaling pathway;KEGG PATHWAY;hsa04310 |
Pathway | Amoebiasis;KEGG PATHWAY;hsa05146 |
Pathway | Melanogenesis;KEGG PATHWAY;hsa04916 |
Pathway | Opioid Signalling;Reactome;REACT:15295 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Endothelin signaling pathway;PANTHER;P00019 |
Pathway | Diabetes pathways;Reactome;REACT:15380 |
Pathway | Alpha adrenergic receptor signaling pathway;PANTHER;P00002 |
Pathway | ionomycin and phorbal ester signaling pathway;PID BioCarta;100121 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | Leukocyte transendothelial migration;KEGG PATHWAY;hsa04670 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | TCR signaling in naive CD8+ T cells;PID Curated;200062 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | Aldosterone-regulated sodium reabsorption;KEGG PATHWAY;hsa04960 |
Pathway | Regulation of Insulin Secretion by Acetylcholine;PID Reactome;500136 |
Pathway | Pathogenic Escherichia coli infection;KEGG PATHWAY;hsa05130 |
Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway;PANTHER;P00027 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | Histamine H1 receptor mediated signaling pathway;PANTHER;P04385 |
Pathway | VEGF signaling pathway;PANTHER;P00056 |
Pathway | Long-term potentiation;KEGG PATHWAY;hsa04720 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Fc epsilon RI signaling pathway;KEGG PATHWAY;hsa04664 |
Pathway | keratinocyte differentiation;PID BioCarta;100119 |
Pathway | Downstream signaling in naive CD8+ T cells;PID Curated;200184 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Canonical NF-kappaB pathway;PID Curated;200026 |
Pathway | Calcium signaling pathway;KEGG PATHWAY;hsa04020 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | a6b1 and a6b4 Integrin signaling;PID Curated;200162 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | mTOR signaling pathway;PID Curated;200080 |
Pathway | Alzheimer disease-amyloid secretase pathway;PANTHER;P00003 |
Pathway | Glioma;KEGG PATHWAY;hsa05214 |
Pathway | Pancreatic secretion;KEGG PATHWAY;hsa04972 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Oxytocin receptor mediated signaling pathway;PANTHER;P04391 |
Pathway | Retinoic acid receptors-mediated signaling;PID Curated;200142 |
Pathway | Gastric acid secretion;KEGG PATHWAY;hsa04971 |
Pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes;PID Curated;200076 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | Apoptosis signaling pathway;PANTHER;P00006 |
Pathway | Long-term depression;KEGG PATHWAY;hsa04730 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | Synaptic Transmission;Reactome;REACT:13685 |
Pathway | Natural killer cell mediated cytotoxicity;KEGG PATHWAY;hsa04650 |
Disease | Pituitary tumor, invasive;OMIM |
Disease | multiple sclerosis;GAD |
Disease | IMMUNE;GAD |
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External Links |
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Links to Entrez Gene | 5578 |
Links to all GeneRIF Items | 5578 |
Links to iHOP | 5578 |
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Sequence Information |
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Nucleotide Sequence |
>5578 : length: 2019 atggctgacgttttcccgggcaacgactccacggcgtctcaggacgtggccaaccgcttc gcccgcaaaggggcgctgaggcagaagaacgtgcacgaggtgaaggaccacaaattcatc gcgcgcttcttcaagcagcccaccttctgcagccactgcaccgacttcatctgggggttt gggaaacaaggcttccagtgccaagtttgctgttttgtggtccacaagaggtgccatgaa tttgttactttttcttgtccgggtgcggataagggacccgacactgatgaccccaggagc aagcacaagttcaaaatccacacttacggaagccccaccttctgcgatcactgtgggtca ctgctctatggacttatccatcaagggatgaaatgtgacacctgcgatatgaacgttcac aagcaatgcgtcatcaatgtccccagcctctgcggaatggatcacactgagaagaggggg cggatttacctaaaggctgaggttgctgatgaaaagctccatgtcacagtacgagatgca aaaaatctaatccctatggatccaaacgggctttcagatccttatgtgaagctgaaactt attcctgatcccaagaatgaaagcaagcaaaaaaccaaaaccatccgctccacactaaat ccgcagtggaatgagtcctttacattcaaattgaaaccttcagacaaagaccgacgactg tctgtagaaatctgggactgggatcgaacaacaaggaatgacttcatgggatccctttcc tttggagtttcggagctgatgaagatgccggccagtggatggtacaagttgcttaaccaa gaagaaggtgagtactacaacgtacccattccggaaggggacgaggaaggaaacatggaa ctcaggcagaaattcgagaaagccaaacttggccctgctggcaacaaagtcatcagtccc tctgaagacaggaaacaaccttccaacaaccttgaccgagtgaaactcacggacttcaat ttcctcatggtgttgggaaaggggagttttggaaaggtgatgcttgccgacaggaagggc acagaagaactgtatgcaatcaaaatcctgaagaaggatgtggtgattcaggatgatgac gtggagtgcaccatggtagaaaagcgagtcttggccctgcttgacaaacccccgttcttg acgcagctgcactcctgcttccagacagtggatcggctgtacttcgtcatggaatatgtc aacggtggggacctcatgtaccacattcagcaagtaggaaaatttaaggaaccacaagca gtattctatgcggcagagatttccatcggattgttctttcttcataaaagaggaatcatt tatagggatctgaagttagataacgtcatgttggattcagaaggacatatcaaaattgct gactttgggatgtgcaaggaacacatgatggatggagtcacgaccaggaccttctgtggg actccagattatatcgccccagagataatcgcttatcagccgtatggaaaatctgtggac tggtgggcctatggcgtcctgttgtatgaaatgcttgccgggcagcctccatttgatggt gaagatgaagacgagctatttcagtctatcatggagcacaacgtttcctatccaaaatcc ttgtccaaggaggctgtttctatctgcaaaggactgatgaccaaacacccagccaagcgg ctgggctgtgggcctgagggggagagggacgtgagagagcatgccttcttccggaggatc gactgggaaaaactggagaacagggagatccagccaccattcaagcccaaagtgtgtggc aaaggagcagagaactttgacaagttcttcacacgaggacagcccgtcttaacaccacct gatcagctggttattgctaacatagaccagtctgattttgaagggttctcgtatgtcaac ccccagtttgtgcaccccatcttacagagtgcagtatga |
Protein Sequence |
>5578 : length: 672 MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGF GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGS LLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDA KNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRL SVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNME LRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKG TEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIA DFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDG EDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPEGERDVREHAFFRRI DWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVN PQFVHPILQSAV |