| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5578 |
Name | PRKCA |
Synonymous | AAG6|PKC-alpha|PKCA|PRKACA;protein kinase C, alpha;PRKCA;protein kinase C, alpha |
Definition | PKC-A|aging-associated gene 6|protein kinase C alpha type |
Position | 17q22-q23.2 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for PRKCA | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
PKCalpha(h) --> pld1(r) (activation) | PKCalpha(h) + pld1a(h) <==> PKCalpha(h):pld1a(h) (binding) | PKCalpha(h) --> pld1b(h) (binding) | PKCalpha(h) + akap5(h) <==> PKCalpha(h):akap5(h) (binding) | PKCalpha(h) + pld2(r) <==> PKCalpha(h):pld2(r) (binding) | PKCalpha(h) + ATP --> PKCalpha(h){p} + ADP (phosphorylation; automodification) | CD91(h) + PKCalpha(h) <==> CD91(h):PKCalpha(h) (binding) | NG2(r) + PKCalpha(h) <==> NG2(r):PKCalpha(h) (binding) | pld1a(h) + PKCalpha(h) <==> pld1a(h):PKCalpha(h) (binding) | PKCalpha(h) --> eNOS(h){pS1179} (increase of phosphorylation) | Syk(h) + PKCalpha(h) <==> Syk(h):PKCalpha(h) (binding) | PKCalpha(h) + SHP-1(h) <==> PKCalpha(h):SHP-1(h) (binding) | SHP1-isoform1(h) + PKCalpha(h) <==> SHP1-isoform1(h):PKCalpha(h) (binding) | c-Cbl(h) + PKCalpha(h) <==> c-Cbl(h):PKCalpha(h) (binding) | PKCalpha(h) + c-Cbl(h) <==> PKCalpha(h):c-Cbl(h) (binding) | PKCalpha(h) + PP2ACalpha(h) <==> PKCalpha(h):PP2ACalpha(h) (binding) | PKCalpha(h) + gja1(h) <==> PKCalpha(h):gja1(h) (binding) | PKCalpha(h) + ATP --> PKCalpha(h){pT250} + ADP (phosphorylation) | PKCalpha(h) --> PKCalpha(h) (translocation) | PKCalpha(h) + ATP --> PKCalpha(h){pY} + ADP (phosphorylation) | Src(h) + PKCalpha(h) <==> Src(h):PKCalpha(h) (binding) | PKCalpha(h) + cytosolic phospholipase A2(h) <==> PKCalpha(h):cytosolic phospholipase A2(h) (binding) | PKCalpha(h) --> IFNB1(h) (transactivation) | PKCalpha(h) --> IRF3(h) (transactivation) | PKCalpha(h) --> IFNbeta(h) (increase of abundance) | IKK(h) + PKCalpha(h) <==> IKK(h):PKCalpha(h) (binding) | PKCalpha(h) + ATP --> PKCalpha(h){p} + ADP (phosphorylation) | PKCalpha(h) --/ UBPY(h) (decrease of abundance) | PRKCA(h) --> PKCalpha(h) (expression). | PKCalpha(h) --> PKCalpha(h) (translocation) | phlpp1(h) --/ PKCalpha(h) (decrease of abundance) | phlpp2(h) --/ PKCalpha(h) (decrease of abundance) | Dkk-1(h) --> PKCalpha(h) (increase of abundance) | Raf-1(h) + ATP --PKCalpha(h)--> Raf-1(h){pS499} + ADP (phosphorylation) | Dvl-2(m) + ATP --PKCalpha(h)--> Dvl-2(m){p} + ADP (phosphorylation) | pld2(r) + 2 NTP --PKCalpha(h)--> pld2(r){pS}{pT} + 2 NDP (phosphorylation) | beta4-integrin(h) + ATP --PKCalpha(h)--> beta4-integrin(h){pS1360}{pS1364} + ADP (phosphorylation) | Bcl-2(m) + ATP --PKCalpha(h)--> Bcl-2(m){pS70} + ADP (phosphorylation) | CD91(h) + ATP --PKCalpha(h)--> CD91(h){pT16}{pS73}{pS76}{pS79} + ADP (phosphorylation) | cTnI(b):cTnT(b):TNNC(b) + 2 ATP --PKCalpha(h)--> cTnT(b){p}:cTnI(b){p}:TNNC(b) + 2 ADP (phosphorylation) | cTnI(b) + 2 ATP --PKCalpha(h)--> cTnI(b){pS78}{pT144} + 2 ADP (phosphorylation) | cTnT(b) + 3 ATP --PKCalpha(h)--> cTnT(b){pS194}{pT199}{pT280} + 3 ADP (phosphorylation) | Bcl-2(h) + ATP --PKCalpha(h)--> Bcl-2(h){pS70} + ADP (phosphorylation) | AKT-1(m.s.) + ATP --PKCalpha(h)--> AKT-1(m.s.){pY} + ADP (phosphorylation) | SHP1-isoform1(h) + ATP --PKCalpha(h)--> SHP1-isoform1(h){pS591} + ADP (phosphorylation) | PKCalpha(h) + beta1-integrin(h) <==> PKCalpha(h):beta1-integrin(h) (binding) | PKCdelta(h) + PKCalpha(h) <==> PKCdelta(h):PKCalpha(h) (binding) | PKCalpha(h) --/ IGF-1(m.s.) (inhibition) | PKCalpha(h) --/ PLCbeta1(r) (inhibition) | PKCalpha(h) + Fascin(h) <==> PKCalpha(h):Fascin(h) (binding) | PKCalpha(h) + RhoA(m.s.) <==> PKCalpha(h):RhoA(m.s.) (binding) | PRKCA(h) --> PKCalpha(h) (expression). | c-Cbl(h) + ATP --PKCalpha(h)--> c-Cbl(h){p} + ADP (phosphorylation) | c-Cbl(h) + ATP --PKCalpha(h)--> c-Cbl(h){p} + ADP (phosphorylation) | PLCbeta1(r) + ATP --PKCalpha(h)--> PLCbeta1(r){pS887} + ADP (phosphorylation) | cTnI(m) + 3 ATP --PKCalpha(h)--> cTnI(m){pS43}{pS45}{pT144} + 3 ADP (phosphorylation) | cTnI(r) + 3 ATP --PKCalpha(h)--> cTnI(r){pS43}{pS45}{pT144} + 3 ADP (phosphorylation) | p300(m.s.) + ATP --PKCalpha(h)--> p300(m.s.){pS89} + ADP (phosphorylation) | PPARalpha(m.s.) + 2 ATP --PKCalpha(h)--> PPARalpha(m.s.){pS179}{pS230} + 2 ADP (phosphorylation) | CYP7(h) + ATP --PKCalpha(h)--> CYP7(h){p} + ADP (phosphorylation) | CLIC1(m.s.) + ATP --PKCalpha(h)--> CLIC1(m.s.){p} + ADP (phosphorylation) | CLIC4(m.s.) + ATP --PKCalpha(h)--> CLIC4(m.s.){p} + ADP (phosphorylation) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
226 | Phosphoserine. | Swiss-Prot 53.0 | 319 | Phosphoserine. | Swiss-Prot 53.0 | 494 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 495 | Phosphothreonine (By similarity). | Swiss-Prot 53.0 | 497 | Phosphothreonine. | Swiss-Prot 53.0 | 501 | Phosphothreonine. | Swiss-Prot 53.0 | 631 | Phosphothreonine (by autocatalysis)(Potential). | Swiss-Prot 53.0 | 638 | Phosphothreonine (by autocatalysis). | Swiss-Prot 53.0 | 657 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 658 | Phosphotyrosine. | Swiss-Prot 53.0 | 225 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 318 | Phosphoserine | 17081983 | Phospho.ELM 6.0 | 657 | Phosphotyrosine (Syk) | 12881490 | Phospho.ELM 6.0 | 656 | Phosphoserine (PKC alpha) | 8856079 | Phospho.ELM 6.0 | 637 | Phosphothreonine | 15314172;14581488 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr17 |
Promoter: 61727888 - 61729888 | Agilent_014791 |
chr17 |
Promoter: 61727888 - 61729888 | IlluminaMethylation27 |
chr17 |
Promoter: 61727888 - 61729888 | GSE27584 |
chr17 |
Promoter: 61727888 - 61729888 | Agilent_014791_44K |
chr17 |
Promoter: 61727888 - 61729888 | Agilent_014791 |