Entrez Gene

Basic Information
Gene ID	5578
Name	PRKCA
Synonymous	AAG6\|PKC-alpha\|PKCA\|PRKACA;protein kinase C, alpha;PRKCA;protein kinase C, alpha
Definition	PKC-A\|aging-associated gene 6\|protein kinase C alpha type
Position	17q22-q23.2
Gene Type	protein-coding
Gene Regulation:	ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

ENCODE RegulomeDB [Top]
	There is no record for PRKCA

Regulation From TransFac database
Transcription Factors [Top]
PKCalpha(h) --> pld1(r) (activation)
PKCalpha(h) + pld1a(h) <==> PKCalpha(h):pld1a(h) (binding)
PKCalpha(h) --> pld1b(h) (binding)
PKCalpha(h) + akap5(h) <==> PKCalpha(h):akap5(h) (binding)
PKCalpha(h) + pld2(r) <==> PKCalpha(h):pld2(r) (binding)
PKCalpha(h) + ATP --> PKCalpha(h){p} + ADP (phosphorylation; automodification)
CD91(h) + PKCalpha(h) <==> CD91(h):PKCalpha(h) (binding)
NG2(r) + PKCalpha(h) <==> NG2(r):PKCalpha(h) (binding)
pld1a(h) + PKCalpha(h) <==> pld1a(h):PKCalpha(h) (binding)
PKCalpha(h) --> eNOS(h){pS1179} (increase of phosphorylation)
Syk(h) + PKCalpha(h) <==> Syk(h):PKCalpha(h) (binding)
PKCalpha(h) + SHP-1(h) <==> PKCalpha(h):SHP-1(h) (binding)
SHP1-isoform1(h) + PKCalpha(h) <==> SHP1-isoform1(h):PKCalpha(h) (binding)
c-Cbl(h) + PKCalpha(h) <==> c-Cbl(h):PKCalpha(h) (binding)
PKCalpha(h) + c-Cbl(h) <==> PKCalpha(h):c-Cbl(h) (binding)
PKCalpha(h) + PP2ACalpha(h) <==> PKCalpha(h):PP2ACalpha(h) (binding)
PKCalpha(h) + gja1(h) <==> PKCalpha(h):gja1(h) (binding)
PKCalpha(h) + ATP --> PKCalpha(h){pT250} + ADP (phosphorylation)
PKCalpha(h) --> PKCalpha(h) (translocation)
PKCalpha(h) + ATP --> PKCalpha(h){pY} + ADP (phosphorylation)
Src(h) + PKCalpha(h) <==> Src(h):PKCalpha(h) (binding)
PKCalpha(h) + cytosolic phospholipase A2(h) <==> PKCalpha(h):cytosolic phospholipase A2(h) (binding)
PKCalpha(h) --> IFNB1(h) (transactivation)
PKCalpha(h) --> IRF3(h) (transactivation)
PKCalpha(h) --> IFNbeta(h) (increase of abundance)
IKK(h) + PKCalpha(h) <==> IKK(h):PKCalpha(h) (binding)
PKCalpha(h) + ATP --> PKCalpha(h){p} + ADP (phosphorylation)
PKCalpha(h) --/ UBPY(h) (decrease of abundance)
PRKCA(h) --> PKCalpha(h) (expression).
PKCalpha(h) --> PKCalpha(h) (translocation)
phlpp1(h) --/ PKCalpha(h) (decrease of abundance)
phlpp2(h) --/ PKCalpha(h) (decrease of abundance)
Dkk-1(h) --> PKCalpha(h) (increase of abundance)
Raf-1(h) + ATP --PKCalpha(h)--> Raf-1(h){pS499} + ADP (phosphorylation)
Dvl-2(m) + ATP --PKCalpha(h)--> Dvl-2(m){p} + ADP (phosphorylation)
pld2(r) + 2 NTP --PKCalpha(h)--> pld2(r){pS}{pT} + 2 NDP (phosphorylation)
beta4-integrin(h) + ATP --PKCalpha(h)--> beta4-integrin(h){pS1360}{pS1364} + ADP (phosphorylation)
Bcl-2(m) + ATP --PKCalpha(h)--> Bcl-2(m){pS70} + ADP (phosphorylation)
CD91(h) + ATP --PKCalpha(h)--> CD91(h){pT16}{pS73}{pS76}{pS79} + ADP (phosphorylation)
cTnI(b):cTnT(b):TNNC(b) + 2 ATP --PKCalpha(h)--> cTnT(b){p}:cTnI(b){p}:TNNC(b) + 2 ADP (phosphorylation)
cTnI(b) + 2 ATP --PKCalpha(h)--> cTnI(b){pS78}{pT144} + 2 ADP (phosphorylation)
cTnT(b) + 3 ATP --PKCalpha(h)--> cTnT(b){pS194}{pT199}{pT280} + 3 ADP (phosphorylation)
Bcl-2(h) + ATP --PKCalpha(h)--> Bcl-2(h){pS70} + ADP (phosphorylation)
AKT-1(m.s.) + ATP --PKCalpha(h)--> AKT-1(m.s.){pY} + ADP (phosphorylation)
SHP1-isoform1(h) + ATP --PKCalpha(h)--> SHP1-isoform1(h){pS591} + ADP (phosphorylation)
PKCalpha(h) + beta1-integrin(h) <==> PKCalpha(h):beta1-integrin(h) (binding)
PKCdelta(h) + PKCalpha(h) <==> PKCdelta(h):PKCalpha(h) (binding)
PKCalpha(h) --/ IGF-1(m.s.) (inhibition)
PKCalpha(h) --/ PLCbeta1(r) (inhibition)
PKCalpha(h) + Fascin(h) <==> PKCalpha(h):Fascin(h) (binding)
PKCalpha(h) + RhoA(m.s.) <==> PKCalpha(h):RhoA(m.s.) (binding)
PRKCA(h) --> PKCalpha(h) (expression).
c-Cbl(h) + ATP --PKCalpha(h)--> c-Cbl(h){p} + ADP (phosphorylation)
c-Cbl(h) + ATP --PKCalpha(h)--> c-Cbl(h){p} + ADP (phosphorylation)
PLCbeta1(r) + ATP --PKCalpha(h)--> PLCbeta1(r){pS887} + ADP (phosphorylation)
cTnI(m) + 3 ATP --PKCalpha(h)--> cTnI(m){pS43}{pS45}{pT144} + 3 ADP (phosphorylation)
cTnI(r) + 3 ATP --PKCalpha(h)--> cTnI(r){pS43}{pS45}{pT144} + 3 ADP (phosphorylation)
p300(m.s.) + ATP --PKCalpha(h)--> p300(m.s.){pS89} + ADP (phosphorylation)
PPARalpha(m.s.) + 2 ATP --PKCalpha(h)--> PPARalpha(m.s.){pS179}{pS230} + 2 ADP (phosphorylation)
CYP7(h) + ATP --PKCalpha(h)--> CYP7(h){p} + ADP (phosphorylation)
CLIC1(m.s.) + ATP --PKCalpha(h)--> CLIC1(m.s.){p} + ADP (phosphorylation)
CLIC4(m.s.) + ATP --PKCalpha(h)--> CLIC4(m.s.){p} + ADP (phosphorylation)

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
226	Phosphoserine.		Swiss-Prot 53.0
319	Phosphoserine.		Swiss-Prot 53.0
494	Phosphothreonine (By similarity).		Swiss-Prot 53.0
495	Phosphothreonine (By similarity).		Swiss-Prot 53.0
497	Phosphothreonine.		Swiss-Prot 53.0
501	Phosphothreonine.		Swiss-Prot 53.0
631	Phosphothreonine (by autocatalysis)(Potential).		Swiss-Prot 53.0
638	Phosphothreonine (by autocatalysis).		Swiss-Prot 53.0
657	Phosphoserine (By similarity).		Swiss-Prot 53.0
658	Phosphotyrosine.		Swiss-Prot 53.0
225	Phosphoserine	17081983	Phospho.ELM 6.0
318	Phosphoserine	17081983	Phospho.ELM 6.0
657	Phosphotyrosine (Syk)	12881490	Phospho.ELM 6.0
656	Phosphoserine (PKC alpha)	8856079	Phospho.ELM 6.0
637	Phosphothreonine	15314172;14581488	Phospho.ELM 6.0

Chromosome	Location	Source
Methylation Profile [Top]
chr17	Promoter: 61727888 - 61729888	Agilent_014791
chr17	Promoter: 61727888 - 61729888	IlluminaMethylation27
chr17	Promoter: 61727888 - 61729888	GSE27584
chr17	Promoter: 61727888 - 61729888	Agilent_014791_44K
chr17	Promoter: 61727888 - 61729888	Agilent_014791

ENCODE RegulomeDB [Top]

Transcription Factors [Top]

Post Transcriptional Modification [Top]

Methylation Profile [Top]