| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 57154 |
Name | SMURF1 |
Synonym | -;SMAD specific E3 ubiquitin protein ligase 1;SMURF1;SMAD specific E3 ubiquitin protein ligase 1 |
Definition | E3 ubiquitin ligase SMURF1|E3 ubiquitin-protein ligase SMURF1|SMAD-specific E3 ubiquitin-protein ligase 1|Smad ubiquitination regulatory factor 1|Smad-specific E3 ubiquitin ligase 1|hSMURF1 |
Position | 7q22.1 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Smurf1 ubiquitin ligase causes downregulation of BMP receptors and is induced in monocrotaline and hypoxia models of pulmonary arterial hypertension. |
| More detail of all Mouse literatures about SMURF1 | |
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Pathways and Diseases |
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Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | estrogen responsive protein efp controls cell cycle and breast tumors growth;PID BioCarta;100182 |
Pathway | BMP receptor signaling;PID Curated;200123 |
Pathway | TGF-beta receptor signaling;PID Curated;200195 |
Pathway | Ubiquitin proteasome pathway;PANTHER;P00060 |
Pathway | Ubiquitin mediated proteolysis;KEGG PATHWAY;hsa04120 |
Pathway | Signaling by BMP;Reactome;REACT:12034 |
Pathway | Signaling events mediated by HDAC Class I;PID Curated;200070 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Signaling by TGF beta;Reactome;REACT:6844 |
Disease | Scleroderma;FunDO |
Disease | IMMUNE;GAD |
Disease | Systemic scleroderma;FunDO |
Disease | Ulcerative colitis;NHGRI |
Disease | Pancreas cancer;FunDO |
Disease | ulcerative colitis;GAD |
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External Links |
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Links to Entrez Gene | 57154 |
Links to all GeneRIF Items | 57154 |
Links to iHOP | 57154 |
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Sequence Information |
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Nucleotide Sequence |
>57154 : length: 2187 atgtcgaaccccgggacacgcaggaacggctccagcatcaagatccgtctgacagtgtta tgtgccaagaaccttgcaaagaaagacttcttcaggctccctgacccttttgcaaagatt gtcgtggatgggtctgggcagtgccactcaaccgacactgtgaaaaacacattggaccca aagtggaaccagcactatgatctatatgttgggaaaacggattcgataaccattagcgtg tggaaccataagaaaattcacaagaaacagggagctggcttcctgggctgtgtgcggctg ctctccaatgccatcagcagattaaaagataccggataccagcgtttggatctatgcaaa ctaaacccctcagatactgatgcagttcgtggccagatagtggtcagtttacagacacga gacagaataggaaccggcggctcggtggtggactgcagaggactgttagaaaatgaagga acggtgtatgaagactccgggcctgggaggccgctcagctgcttcatggaggaaccagcc ccttacacagatagcaccggtgctgctgctggaggagggaattgcaggttcgtggagtcc ccaagtcaagatcaaagacttcaggcacagcggcttcgaaaccctgatgtgcgaggttca ctacagacgccccagaaccgaccacacggccaccagtccccggaactgcccgaaggctac gaacaaagaacaacagtccagggccaagtttactttttgcatacacagactggagttagc acgtggcacgaccccaggataccaagagaccttaacagtgtgaactgtgatgaacttgga ccactgccgccaggctgggaagtcagaagtacagtttctgggaggatatattttgtagat cataataaccgaacaacccagtttacagacccaaggttacaccacatcatgaatcaccag tgccaactcaaggagcccagccagccgctgccactgcccagtgagggctctctggaggac gaggagcttcctgcccagagatacgaaagagatctagtccagaagctgaaagtcctcaga cacgaactgtcgcttcagcagccccaagctggtcattgccgcatcgaagtgtccagagaa gaaatctttgaggagtcttaccgccagataatgaagatgcgaccgaaagacttgaaaaaa cggctgatggtgaaattccgtggggaagaaggtttggattacggtggtgtggccagggag tggctttacttgctgtgccatgaaatgctgaatccttattacgggctcttccagtattct acggacaatatttacatgttgcaaataaatccggattcttcaatcaaccccgaccacttg tcttatttccactttgtggggcggatcatggggctggctgtgttccatggacactacatc aacgggggcttcacagtgcccttctacaagcagctgctggggaagcccatccagctctca gatctggaatctgtggacccagagctgcataagagcttggtgtggatcctagagaacgac atcacgcctgtactggaccacaccttctgcgtggaacacaacgccttcgggcggatcctg cagcatgaactgaaacccaatggcagaaatgtgccagtcacagaggagaataagaaagaa tacgtccggttgtatgtaaactggaggtttatgagaggaatcgaagcccagttcttagct ctgcagaaggggttcaatgagctcatccctcaacatctgctgaagccttttgaccagaag gaactggagctgatcataggcggcctggataaaatagacttgaacgactggaagtcgaac acgcggctgaagcactgtgtggccgacagcaacatcgtgcggtggttctggcaagcggtg gagacgttcgatgaagaaaggagggccaggctcctgcagtttgtgactgggtccacgcga gtcccgctccaaggcttcaaggctttgcaaggcgcggcagggccccggctgttcaccatc cacctgatagacgcgaacacagacaaccttccgaaggcccatacctgctttaaccggatc gacattccaccatatgagtcctatgagaagctctacgagaagctgctgacagccgtggag gagacctgcgggtttgctgtggagtga |
Protein Sequence |
>57154 : length: 728 MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDP KWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCK LNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPA PYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGY EQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVD HNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLR HELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVARE WLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYI NGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRIL QHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQK ELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTR VPLQGFKALQGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVE ETCGFAVE |