| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 57154 |
Name | SMURF1 |
Synonymous | -;SMAD specific E3 ubiquitin protein ligase 1;SMURF1;SMAD specific E3 ubiquitin protein ligase 1 |
Definition | E3 ubiquitin ligase SMURF1|E3 ubiquitin-protein ligase SMURF1|SMAD-specific E3 ubiquitin-protein ligase 1|Smad ubiquitination regulatory factor 1|Smad-specific E3 ubiquitin ligase 1|hSMURF1 |
Position | 7q22.1 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr7:98625061-98741723 | chr7:98644032-98644032 | rs219823 | Single_Nucleotides|eQTL|BUD31, Motifs|PWM|IRC900814, Chromatin_Structure|DNase-seq|Sknmc | chr7:98625061-98741723 | chr7:98650099-98650099 | rs219798 | Single_Nucleotides|eQTL|PTCD1, Motifs|PWM|Rfx3, Chromatin_Structure|DNase-seq|A549 | chr7:98625061-98741723 | chr7:98733337-98733337 | rs6952161 | Single_Nucleotides|eQTL|TECPR1, Motifs|PWM|MECP2, Chromatin_Structure|FAIRE|Mcf7, Chromatin_Structure|DNase-seq|Saec |
|---|---|---|---|
Transcription Factors [Top] |
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Regulation From TransFac database |
TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h):Smad7(m){p} + Smurf-1(h) <==> TGFbeta1(h):TGFbetaR-II(h):TGFbetaR-I(h):Smad7(m){p}:Smurf-1(h) (binding) | Smad1(h) + Smurf-1(h) <==> Smad1(h):Smurf-1(h) (binding) | Smad5(m) + Smurf-1(h) <==> Smad5(m):Smurf-1(h) (binding) | Smad6(m){p} + Smurf-1(h) <==> Smad6(m){p}:Smurf-1(h) (binding) | Smad7(m){p} + Smurf-1(h) <==> Smad7(m){p}:Smurf-1(h) (binding) | talin head(m) + Smurf-1(h) <==> talin head(m):Smurf-1(h) (binding) | Smad7(m){p}:Smurf-1(h) + n ubiquitin(h) --> Smad7(m){p}{ub(n)} + Smurf-1(h) (ubiquitination; dissociation) | SMURF1(h) --> Smurf-1(h) (expression). | Smad1(x) + n ubiquitin(v.s.) --Smurf-1(h)--> Smad1(x){ub(n)} (ubiquitination) | TGFbetaR-I(h) + n ubiquitin(h) --Smurf-1(h)--> TGFbetaR-I(h){ub(n)} (ubiquitination) | SMURF1(h) --> Smurf-1-xbb1(h) (expression). | SMURF1(h) --> Smurf-1-L(h) (expression). | SMURF1(h) --> Smurf-1-S(h) (expression). |
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Post Transcriptional Modification [Top] | |||
There is no record for SMURF1 | |||
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr7 |
Promoter: 98579159 - 98581159 | Agilent_014791 |
chr7 |
Promoter: 98579159 - 98581159 | GSE27584 |
chr7 |
Promoter: 98579159 - 98581159 | GSE27584 |
chr7 |
Promoter: 98579159 - 98581159 | Agilent_014791_44K |