| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 5740 |
Name | PTGIS |
Synonym | CYP8|CYP8A1|PGIS|PTGI;prostaglandin I2 (prostacyclin) synthase;PTGIS;prostaglandin I2 (prostacyclin) synthase |
Definition | cytochrome P450, family 8, subfamily A, polypeptide 1|prostacyclin synthase|prostaglandin I2 synthase |
Position | 20q13.13 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Polymorphism of the promoter region of prostacyclin synthase gene in chronic thromboembolic pulmonary hypertension. |
PAH | Adenoassociated virus-mediated prostacyclin synthase expression prevents pulmonary arterial hypertension in rats. |
PAH | Gene transfer therapy by either type 1 or type 2 adeno-associated virus expressing human prostaglandin I2 synthase gene is effective for treatment of pulmonary arterial hypertension. |
PH | Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats. |
| More detail of all Human literatures about PTGIS | |
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Pathways and Diseases |
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Pathway | Prostanoid metabolism;PID Reactome;500770 |
Pathway | Eicosanoids;PID Reactome;500201 |
Pathway | Metabolic pathways;KEGG PATHWAY;hsa01100 |
Pathway | eicosanoid metabolism;PID BioCarta;100180 |
Pathway | Biological oxidations;Reactome;REACT:13433 |
Pathway | Metabolism of lipids and lipoproteins;Reactome;REACT:22258 |
Pathway | prostanoid biosynthesis;BioCyc;PWY66-374 |
Pathway | Hormone biosynthesis;Reactome;REACT:15314 |
Pathway | Arachidonic acid metabolism;KEGG PATHWAY;hsa00590 |
Disease | REPRODUCTION;GAD |
Disease | hypertension;GAD |
Disease | breast cancer;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | cardiovascular;GAD |
Disease | CANCER;GAD |
Disease | Myocardial Infarction;GAD |
Disease | Hypertension, essential;OMIM |
Disease | Cerebral Infarction;GAD |
Disease | patent ductus arteriosus;GAD |
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External Links |
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Links to Entrez Gene | 5740 |
Links to all GeneRIF Items | 5740 |
Links to iHOP | 5740 |
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Sequence Information |
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Nucleotide Sequence |
>5740 : length: 1503 atggcttgggccgcgctcctcggcctcctggccgcactgttgctgctgctgctactgagc cgccgccgcacgcggcgacctggtgagcctcccctggacctgggcagcatcccctggttg gggtatgccttggactttggaaaagatgctgccagcttcctcacgaggatgaaggagaag cacggtgacatctttactatactggttgggggcaggtatgtcaccgttctcctggaccca cactcctacgacgcggtggtgtgggagcctcgcaccaggctcgacttccatgcctatgcc atcttcctcatggagaggatttttgatgtgcagcttccacattacagccccagtgatgaa aaggccaggatgaaactgactcttctccacagagagctccaggcactcacagaagccatg tataccaacctccatgcagtgctgttgggcgatgctacagaagcaggcagtggctggcac gagatgggtctcctcgacttctcctacagcttcctgctcagagccggctacctgactctt tacggaattgaggcgctgccacgcacccatgaaagccaggcccaggaccgcgtccactca gctgatgtcttccacacctttcgccagctcgaccggctgctccccaaactggcccgtggc tccctgtcagtgggggacaaggaccacatgtgcagtgtcaaaagtcgcctgtggaagctg ctatccccagccaggctggccaggcgggcccaccggagcaaatggctggagagttacctg ctgcacctggaggagatgggtgtgtcagaggagatgcaggcacgggccctggtgctgcag ctgtgggccacacaggggaatatgggtcccgctgccttctggctcctgctcttccttctc aagaatcctgaagccctggctgctgtccgcggagagctcgagagtatcctttggcaagcg gagcagcctgtctcgcagacgaccactctcccacagaaggttctagacagcacacctgtg cttgatagcgtgctgagtgagagcctcaggcttacagctgcccccttcatcacccgcgag gttgtggtggacctggccatgcccatggcagacgggcgagaattcaacctgcgacgtggt gaccgcctcctcctcttccccttcctgagcccccagagagacccagaaatctacacagac ccagaggtatttaaatacaaccgattcctgaaccctgacggatcagagaagaaagacttt tacaaggatgggaaacggctgaagaattacaacatgccctggggggcggggcacaatcac tgcctggggaggagttatgcggtcaacagcatcaaacaatttgtgttccttgtgctggtg cacttggacttggagctgatcaacgcagatgtggagatccctgagtttgacctcagcagg tacggcttcggtctgatgcagccggaacacgacgtgcccgtccgctaccgcatccgccca tga |
Protein Sequence |
>5740 : length: 500 MAWAALLGLLAALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYALDFGKDAASFLTRMKEK HGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIFLMERIFDVQLPHYSPSDE KARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWHEMGLLDFSYSFLLRAGYLTL YGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLARGSLSVGDKDHMCSVKSRLWKL LSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL KNPEALAAVRGELESILWQAEQPVSQTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITRE VVVDLAMPMADGREFNLRRGDRLLLFPFLSPQRDPEIYTDPEVFKYNRFLNPDGSEKKDF YKDGKRLKNYNMPWGAGHNHCLGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSR YGFGLMQPEHDVPVRYRIRP |