| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 652 |
Name | BMP4 |
Synonym | BMP2B|BMP2B1|MCOPS6|OFC11|ZYME;bone morphogenetic protein 4;BMP4;bone morphogenetic protein 4 |
Definition | BMP-2B|BMP-4|bone morphogenetic protein 2B |
Position | 14q22-q23 |
Gene Type | protein-coding |
|
PAH Type |
Description |
HPH | Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension. |
PAH | BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways. |
PAH | Functional characterization of bone morphogenetic protein binding sites and Smad1/5 activation in human vascular cells. |
| More detail of all Mouse literatures about BMP4 | |
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Pathways and Diseases |
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Pathway | alk in cardiac myocytes;PID BioCarta;100244 |
Pathway | Glypican 3 network;PID Curated;200193 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | Basal cell carcinoma;KEGG PATHWAY;hsa05217 |
Pathway | Hedgehog signaling pathway;KEGG PATHWAY;hsa04340 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Disease | Hypertension;FunDO |
Disease | Colorectal cancer;NHGRI |
Disease | Diabetes mellitus;FunDO |
Disease | Microphthalmia, syndromic 6;OMIM |
Disease | Parkinson's disease;GAD |
Disease | Spinal dysraphism;FunDO |
Disease | Rheumatoid arthritis;FunDO |
Disease | Parkinson's disease;NHGRI |
Disease | Cleft palate;FunDO |
Disease | CANCER;GAD |
Disease | Cancer;FunDO |
Disease | Polyarthritis;FunDO |
Disease | Orofacial cleft 11;OMIM |
Disease | NEUROLOGICAL;GAD |
Disease | colorectal cancer;GAD |
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External Links |
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Links to Entrez Gene | 652 |
Links to all GeneRIF Items | 652 |
Links to iHOP | 652 |
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Sequence Information |
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Nucleotide Sequence |
>652 : length: 1227 atgattcctggtaaccgaatgctgatggtcgttttattatgccaagtcctgctaggaggc gcgagccatgctagtttgatacctgagacggggaagaaaaaagtcgccgagattcagggc cacgcgggaggacgccgctcagggcagagccatgagctcctgcgggacttcgaggcgaca cttctgcagatgtttgggctgcgccgccgcccgcagcctagcaagagtgccgtcattccg gactacatgcgggatctttaccggcttcagtctggggaggaggaggaagagcagatccac agcactggtcttgagtatcctgagcgcccggccagccgggccaacaccgtgaggagcttc caccacgaagaacatctggagaacatcccagggaccagtgaaaactctgcttttcgtttc ctctttaacctcagcagcatccctgagaacgaggtgatctcctctgcagagcttcggctc ttccgggagcaggtggaccagggccctgattgggaaaggggcttccaccgtataaacatt tatgaggttatgaagcccccagcagaagtggtgcctgggcacctcatcacacgactactg gacacgagactggtccaccacaatgtgacacggtgggaaacttttgatgtgagccctgcg gtccttcgctggacccgggagaagcagccaaactatgggctagccattgaggtgactcac ctccatcagactcggacccaccagggccagcatgtcaggattagccgatcgttacctcaa gggagtgggaattgggcccagctccggcccctcctggtcacctttggccatgatggccgg ggccatgccttgacccgacgccggagggccaagcgtagccctaagcatcactcacagcgg gccaggaagaagaataagaactgccggcgccactcgctctatgtggacttcagcgatgtg ggctggaatgactggattgtggccccaccaggctaccaggccttctactgccatggggac tgcccctttccactggctgaccacctcaactcaaccaaccatgccattgtgcagaccctg gtcaattctgtcaattccagtatccccaaagcctgttgtgtgcccactgaactgagtgcc atctccatgctgtacctggatgagtatgataaggtggtactgaaaaattatcaggagatg gtagtagagggatgtgggtgccgctga |
Protein Sequence |
>652 : length: 408 MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR |