Pulmonary Arterial Hypertension KnowledgeBase (PAHKB)
PAHKB
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

652

Name

BMP4

Synonym

BMP2B|BMP2B1|MCOPS6|OFC11|ZYME;bone morphogenetic protein 4;BMP4;bone morphogenetic protein 4

Definition

BMP-2B|BMP-4|bone morphogenetic protein 2B

Position

14q22-q23

Gene Type

protein-coding

PAH Type

Description

HPH

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension.

PAH

BMP4 inhibits proliferation and promotes myocyte differentiation of lung fibroblasts via Smad1 and JNK pathways.

PAH

Functional characterization of bone morphogenetic protein binding sites and Smad1/5 activation in human vascular cells.
More detail of all Mouse literatures about BMP4

Pathways and Diseases

Pathway

alk in cardiac myocytes;PID BioCarta;100244

Pathway

Glypican 3 network;PID Curated;200193

Pathway

TGF-beta signaling pathway;PANTHER;P00052

Pathway

Basal cell carcinoma;KEGG PATHWAY;hsa05217

Pathway

Hedgehog signaling pathway;KEGG PATHWAY;hsa04340

Pathway

TGF-beta signaling pathway;KEGG PATHWAY;hsa04350

Pathway

Pathways in cancer;KEGG PATHWAY;hsa05200

Disease

Hypertension;FunDO

Disease

Colorectal cancer;NHGRI

Disease

Diabetes mellitus;FunDO

Disease

Microphthalmia, syndromic 6;OMIM

Disease

Parkinson's disease;GAD

Disease

Spinal dysraphism;FunDO

Disease

Rheumatoid arthritis;FunDO

Disease

Parkinson's disease;NHGRI

Disease

Cleft palate;FunDO

Disease

CANCER;GAD

Disease

Cancer;FunDO

Disease

Polyarthritis;FunDO

Disease

Orofacial cleft 11;OMIM

Disease

NEUROLOGICAL;GAD

Disease

colorectal cancer;GAD

External Links

Links to Entrez Gene

652

Links to all GeneRIF Items

652

Links to iHOP

652

Sequence Information

Nucleotide Sequence

>652 : length: 1227
atgattcctggtaaccgaatgctgatggtcgttttattatgccaagtcctgctaggaggc
gcgagccatgctagtttgatacctgagacggggaagaaaaaagtcgccgagattcagggc
cacgcgggaggacgccgctcagggcagagccatgagctcctgcgggacttcgaggcgaca
cttctgcagatgtttgggctgcgccgccgcccgcagcctagcaagagtgccgtcattccg
gactacatgcgggatctttaccggcttcagtctggggaggaggaggaagagcagatccac
agcactggtcttgagtatcctgagcgcccggccagccgggccaacaccgtgaggagcttc
caccacgaagaacatctggagaacatcccagggaccagtgaaaactctgcttttcgtttc
ctctttaacctcagcagcatccctgagaacgaggtgatctcctctgcagagcttcggctc
ttccgggagcaggtggaccagggccctgattgggaaaggggcttccaccgtataaacatt
tatgaggttatgaagcccccagcagaagtggtgcctgggcacctcatcacacgactactg
gacacgagactggtccaccacaatgtgacacggtgggaaacttttgatgtgagccctgcg
gtccttcgctggacccgggagaagcagccaaactatgggctagccattgaggtgactcac
ctccatcagactcggacccaccagggccagcatgtcaggattagccgatcgttacctcaa
gggagtgggaattgggcccagctccggcccctcctggtcacctttggccatgatggccgg
ggccatgccttgacccgacgccggagggccaagcgtagccctaagcatcactcacagcgg
gccaggaagaagaataagaactgccggcgccactcgctctatgtggacttcagcgatgtg
ggctggaatgactggattgtggccccaccaggctaccaggccttctactgccatggggac
tgcccctttccactggctgaccacctcaactcaaccaaccatgccattgtgcagaccctg
gtcaattctgtcaattccagtatccccaaagcctgttgtgtgcccactgaactgagtgcc
atctccatgctgtacctggatgagtatgataaggtggtactgaaaaattatcaggagatg
gtagtagagggatgtgggtgccgctga

Protein Sequence

>652 : length: 408
MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEAT
LLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEQIHSTGLEYPERPASRANTVRSF
HHEEHLENIPGTSENSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWERGFHRINI
YEVMKPPAEVVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTH
LHQTRTHQGQHVRISRSLPQGSGNWAQLRPLLVTFGHDGRGHALTRRRRAKRSPKHHSQR
ARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTL
VNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR



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