| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 658 |
Name | BMPR1B |
Synonym | ALK-6|ALK6|CDw293;bone morphogenetic protein receptor, type IB;BMPR1B;bone morphogenetic protein receptor, type IB |
Definition | BMP type-1B receptor|BMPR-1B|activin receptor-like kinase 6|bone morphogenetic protein receptor type-1B|serine/threonine receptor kinase |
Position | 4q22-q24 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action. |
PAH | Suggest that BMPR1B mutations are associated with the pathogenesis of childhood idiopathic pulmonary arterial hypertension. |
PH | Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. |
PH | Bone morphogenetic protein signalling in heritable versus idiopathic pulmonary hypertension. |
| More detail of all Human literatures about BMPR1B | |
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Pathways and Diseases |
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Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | Wnt signaling pathway;PANTHER;P00057 |
Pathway | Signaling by BMP;Reactome;REACT:12034 |
Disease | increased ovulation rate;GAD |
Disease | REPRODUCTION;GAD |
Disease | Brachydactyly, type A2;OMIM |
Disease | Attention deficit hyperactivity disorder;NHGRI |
Disease | Prostate cancer;FunDO |
Disease | Chrondrodysplasia, acromesomelic, with genital anomalies;OMIM |
Disease | Asthma;FunDO |
Disease | Hypertension, Pulmonary;FunDO |
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External Links |
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Links to Entrez Gene | 658 |
Links to all GeneRIF Items | 658 |
Links to iHOP | 658 |
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Sequence Information |
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Nucleotide Sequence |
>658 : length: 1509 atgcttttgcgaagtgcaggaaaattaaatgtgggcaccaagaaagaggatggtgagagt acagcccccaccccccgtccaaaggtcttgcgttgtaaatgccaccaccattgtccagaa gactcagtcaacaatatttgcagcacagacggatattgtttcacgatgatagaagaggat gactctgggttgcctgtggtcacttctggttgcctaggactagaaggctcagattttcag tgtcgggacactcccattcctcatcaaagaagatcaattgaatgctgcacagaaaggaac gaatgtaataaagacctacaccctacactgcctccattgaaaaacagagattttgttgat ggacctatacaccacagggctttacttatatctgtgactgtctgtagtttgctcttggtc cttatcatattattttgttacttccggtataaaagacaagaaaccagacctcgatacagc attgggttagaacaggatgaaacttacattcctcctggagaatccctgagagacttaatt gagcagtctcagagctcaggaagtggatcaggcctccctctgctggtccaaaggactata gctaagcagattcagatggtgaaacagattggaaaaggtcgctatggggaagtttggatg ggaaagtggcgtggcgaaaaggtagctgtgaaagtgttcttcaccacagaggaagccagc tggttcagagagacagaaatatatcagacagtgttgatgaggcatgaaaacattttgggt ttcattgctgcagatatcaaagggacagggtcctggacccagttgtacctaatcacagac tatcatgaaaatggttccctttatgattatctgaagtccaccaccctagacgctaaatca atgctgaagttagcctactcttctgtcagtggcttatgtcatttacacacagaaatcttt agtactcaaggcaaaccagcaattgcccatcgagatctgaaaagtaaaaacattctggtg aagaaaaatggaacttgctgtattgctgacctgggcctggctgttaaatttattagtgat acaaatgaagttgacataccacctaacactcgagttggcaccaaacgctatatgcctcca gaagtgttggacgagagcttgaacagaaatcacttccagtcttacatcatggctgacatg tatagttttggcctcatcctttgggaggttgctaggagatgtgtatcaggaggtatagtg gaagaataccagcttccttatcatgacctagtgcccagtgacccctcttatgaggacatg agggagattgtgtgcatcaagaagttacgcccctcattcccaaaccggtggagcagtgat gagtgtctaaggcagatgggaaaactcatgacagaatgctgggctcacaatcctgcatca aggctgacagccctgcgggttaagaaaacacttgccaaaatgtcagagtcccaggacatt aaactctga |
Protein Sequence |
>658 : length: 502 MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS RLTALRVKKTLAKMSESQDIKL |