| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 659 |
Name | BMPR2 |
Synonym | BMPR-II|BMPR3|BMR2|BRK-3|PPH1|T-ALK;bone morphogenetic protein receptor, type II (serine/threonine kinase);BMPR2;bone morphogenetic protein receptor, type II (serine/threonine kinase) |
Definition | BMP type II receptor|BMP type-2 receptor|BMPR-2|bone morphogenetic protein receptor type II|bone morphogenetic protein receptor type-2|type II activin receptor-like kinase|type II receptor for bone morphogenetic protein-4 |
Position | 2q33-q34 |
Gene Type | protein-coding |
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PAH Type |
Description |
HPH | Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature. |
PAH | "Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta family." |
PAH | BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension. |
PAH | BMPR2 germline mutations in pulmonary hypertension associated with fenfluramine derivatives. |
PAH | Pulmonary hypertension in scleroderma spectrum of disease: lack of bone morphogenetic protein receptor 2 mutations. |
PAH | Pulmonary hypertension in transgenic mice expressing a dominant-negative BMPRII gene in smooth muscle. |
PAH | Low frequency of BMPR2 mutations in a German cohort of patients with sporadic idiopathic pulmonary arterial hypertension. |
PAH | Transforming growth factor-beta receptor mutations and pulmonary arterial hypertension in childhood. |
PAH | Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension. |
PAH | A dual-light reporter system to determine the efficiency of protein-protein interactions in mammalian cells. |
| More detail of all Mouse literatures about BMPR2 | |
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Pathways and Diseases |
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Pathway | BMP receptor signaling;PID Curated;200123 |
Pathway | Cytokine-cytokine receptor interaction;KEGG PATHWAY;hsa04060 |
Pathway | Signaling by BMP;Reactome;REACT:12034 |
Pathway | ALK1 signaling events;PID Curated;200126 |
Pathway | TGF-beta signaling pathway;PANTHER;P00052 |
Pathway | ALK2 signaling events;PID Curated;200138 |
Pathway | TGF-beta signaling pathway;KEGG PATHWAY;hsa04350 |
Pathway | alk in cardiac myocytes;PID BioCarta;100244 |
Disease | Renal Cell cancer;FunDO |
Disease | Hypertension;FunDO |
Disease | hypertension;GAD |
Disease | CARDIOVASCULAR;GAD |
Disease | Prostate cancer;FunDO |
Disease | Pulmonary venoocclusive disease;OMIM |
Disease | Asthma;FunDO |
Disease | Lung cancer;FunDO |
Disease | Pulmonary hypertension, familial primary;OMIM |
Disease | Congenital heart disease;FunDO |
Disease | Pulmonary hypertension;FunDO |
Disease | Rabies;FunDO |
Disease | Pulmonary hypertension, primary, fenfluramine-associated;OMIM |
Disease | Breast cancer;FunDO |
Disease | Capillaries disease;FunDO |
Disease | Vascular disease;FunDO |
Disease | Hypertension, Pulmonary;FunDO |
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External Links |
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Links to Entrez Gene | 659 |
Links to all GeneRIF Items | 659 |
Links to iHOP | 659 |
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Sequence Information |
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Nucleotide Sequence |
>659 : length: 3117 atgacttcctcgctgcagcggccctggcgggtgccctggctaccatggaccatcctgctg gtcagcactgcggctgcttcgcagaatcaagaacggctatgtgcgtttaaagatccgtat cagcaagaccttgggataggtgagagtagaatctctcatgaaaatgggacaatattatgc tcgaaaggtagcacctgctatggcctttgggagaaatcaaaaggggacataaatcttgta aaacaaggatgttggtctcacattggagatccccaagagtgtcactatgaagaatgtgta gtaactaccactcctccctcaattcagaatggaacataccgtttctgctgttgtagcaca gatttatgtaatgtcaactttactgagaattttccacctcctgacacaacaccactcagt ccacctcattcatttaaccgagatgagacaataatcattgctttggcatcagtctctgta ttagctgttttgatagttgccttatgctttggatacagaatgttgacaggagaccgtaaa caaggtcttcacagtatgaacatgatggaggcagcagcatccgaaccctctcttgatcta gataatctgaaactgttggagctgattggccgaggtcgatatggagcagtatataaaggc tccttggatgagcgtccagttgctgtaaaagtgttttcctttgcaaaccgtcagaatttt atcaacgaaaagaacatttacagagtgcctttgatggaacatgacaacattgcccgcttt atagttggagatgagagagtcactgcagatggacgcatggaatatttgcttgtgatggag tactatcccaatggatctttatgcaagtatttaagtctccacacaagtgactgggtaagc tcttgccgtcttgctcattctgttactagaggactggcttatcttcacacagaattacca cgaggagatcattataaacctgcaatttcccatcgagatttaaacagcagaaatgtccta gtgaaaaatgatggaacctgtgttattagtgactttggactgtccatgaggctgactgga aatagactggtgcgcccaggggaggaagataatgcagccataagcgaggttggcactatc agatatatggcaccagaagtgctagaaggagctgtgaacttgagggactgtgaatcagct ttgaaacaagtagacatgtatgctcttggactaatctattgggagatatttatgagatgt acagacctcttcccaggggaatccgtaccagagtaccagatggcttttcagacagaggtt ggaaaccatcccacttttgaggatatgcaggttctcgtgtctagggaaaaacagagaccc aagttcccagaagcctggaaagaaaatagcctggcagtgaggtcactcaaggagacaatc gaagactgttgggaccaggatgcagaggctcggcttactgcacagtgtgctgaggaaagg atggctgaacttatgatgatttgggaaagaaacaaatctgtgagcccaacagtcaatcca atgtctactgctatgcagaatgaacgcaacctgtcacataataggcgtgtgccaaaaatt ggtccttatccagattattcttcctcctcatacattgaagactctatccatcatactgac agcatcgtgaagaatatttcctctgagcattctatgtccagcacacctttgactataggg gaaaaaaaccgaaattcaattaactatgaacgacagcaagcacaagctcgaatccccagc cctgaaacaagtgtcaccagcctctccaccaacacaacaaccacaaacaccacaggactc acgccaagtactggcatgactactatatctgagatgccatacccagatgaaacaaatctg cataccacaaatgttgcacagtcaattgggccaacccctgtctgcttacagctgacagaa gaagacttggaaaccaacaagctagacccaaaagaagttgataagaacctcaaggaaagc tctgatgagaatctcatggagcactctcttaaacagttcagtggcccagacccactgagc agtactagttctagcttgctttacccactcataaaacttgcagtagaagcaactggacag caggacttcacacagactgcaaatggccaagcatgtttgattcctgatgttctgcctact cagatctatcctctccccaagcagcagaaccttcccaagagacctactagtttgcctttg aacaccaaaaattcaacaaaagagccccggctaaaatttggcagcaagcacaaatcaaac ttgaaacaagtcgaaactggagttgccaagatgaatacaatcaatgcagcagaacctcat gtggtgacagtcaccatgaatggtgtggcaggtagaaaccacagtgttaactcccatgct gccacaacccaatatgccaatgggacagtactatctggccaaacaaccaacatagtgaca catagggcccaagaaatgttgcagaatcagtttattggtgaggacacccggctgaatatt aattccagtcctgatgagcatgagcctttactgagacgagagcaacaagctggccatgat gaaggtgttctggatcgtcttgtggacaggagggaacggccactagaaggtggccgaact aattccaataacaacaacagcaatccatgttcagaacaagatgttcttgcacagggtgtt ccaagcacagcagcagatcctgggccatcaaagcccagaagagcacagaggcctaattct ctggatctttcagccacaaatgtcctggatggcagcagtatacagataggtgagtcaaca caagatggcaaatcaggatcaggtgaaaagatcaagaaacgtgtgaaaactccctattct cttaagcggtggcgcccctccacctgggtcatctccactgaatcgctggactgtgaagtc aacaataatggcagtaacagggcagttcattccaaatccagcactgctgtttaccttgca gaaggaggcactgctacaaccatggtgtctaaagatataggaatgaactgtctgtga |
Protein Sequence |
>659 : length: 1038 MTSSLQRPWRVPWLPWTILLVSTAAASQNQERLCAFKDPYQQDLGIGESRISHENGTILC SKGSTCYGLWEKSKGDINLVKQGCWSHIGDPQECHYEECVVTTTPPSIQNGTYRFCCCST DLCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALASVSVLAVLIVALCFGYRMLTGDRK QGLHSMNMMEAAASEPSLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNF INEKNIYRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVS SCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTG NRLVRPGEEDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEIFMRC TDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETI EDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKI GPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSSTPLTIGEKNRNSINYERQQAQARIPS PETSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETNLHTTNVAQSIGPTPVCLQLTE EDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQ QDFTQTANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKNSTKEPRLKFGSKHKSN LKQVETGVAKMNTINAAEPHVVTVTMNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVT HRAQEMLQNQFIGEDTRLNINSSPDEHEPLLRREQQAGHDEGVLDRLVDRRERPLEGGRT NSNNNNSNPCSEQDVLAQGVPSTAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGEST QDGKSGSGEKIKKRVKTPYSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLA EGGTATTMVSKDIGMNCL |