| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6714 |
Name | SRC |
Synonym | ASV|SRC1|c-SRC|p60-Src;v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian);SRC;v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
Definition | proto-oncogene c-Src|proto-oncogene tyrosine-protein kinase Src|protooncogene SRC, Rous sarcoma|tyrosine kinase pp60c-src|tyrosine-protein kinase SRC-1 |
Position | 20q12-q13 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | CONCLUSIONS: We suggest that dual inhibition of PDGF receptor and Src kinases potently inhibits mitogenic and motogenic responses to growth factors in PASMCs and pulmonary vascular remodeling in vivo so that dual inhibition may represent an alternative therapeutic approach for pulmonary arterial hypertension. |
| More detail of all Human literatures about SRC | |
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Pathways and Diseases |
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Pathway | S1P3 pathway;PID Curated;200035 |
Pathway | Regulation of p38-alpha and p38-beta;PID Curated;200054 |
Pathway | Axon guidance;Reactome;REACT:18266 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | sprouty regulation of tyrosine kinase signals;PID BioCarta;100029 |
Pathway | Bacterial invasion of epithelial cells;KEGG PATHWAY;hsa05100 |
Pathway | Adherens junction;KEGG PATHWAY;hsa04520 |
Pathway | Signaling by EGFR;Reactome;REACT:9417 |
Pathway | EPHB forward signaling;PID Curated;200041 |
Pathway | Syndecan-3-mediated signaling events;PID Curated;200170 |
Pathway | regulation of splicing through sam68;PID BioCarta;100036 |
Pathway | Glypican 1 network;PID Curated;200021 |
Pathway | EPHA2 forward signaling;PID Curated;200185 |
Pathway | Endothelins;PID Curated;200004 |
Pathway | Cadherin signaling pathway;PANTHER;P00012 |
Pathway | how progesterone initiates the oocyte maturation;PID BioCarta;100104 |
Pathway | E-cadherin signaling in the nascent adherens junction;PID Curated;200105 |
Pathway | EPHA forward signaling;PID Curated;200121 |
Pathway | erk1/erk2 mapk signaling pathway;PID BioCarta;100170 |
Pathway | Paxillin-independent events mediated by a4b1 and a4b7;PID Curated;200178 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | ADP signalling through P2Y purinoceptor 1;PID Reactome;500292 |
Pathway | Interactions of the immunoglobulin superfamily (IgSF) member proteins;Reactome;REACT:23853 |
Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | Class I PI3K signaling events mediated by Akt;PID Curated;200169 |
Pathway | roles of beta arrestin dependent recruitment of src kinases in gpcr signaling;PID BioCarta;100230 |
Pathway | p38MAPK events;PID Reactome;500627 |
Pathway | Signaling events mediated by PRL;PID Curated;200006 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | Recycling pathway of L1;PID Reactome;500098 |
Pathway | Membrane Trafficking;Reactome;REACT:11123 |
Pathway | cbl mediated ligand-induced downregulation of egf receptors pathway;PID BioCarta;100216 |
Pathway | CXCR3-mediated signaling events;PID Curated;200150 |
Pathway | cell to cell adhesion signaling;PID BioCarta;100208 |
Pathway | pelp1 modulation of estrogen receptor activity;PID BioCarta;100076 |
Pathway | ucalpain and friends in cell spread;PID BioCarta;100008 |
Pathway | Epithelial cell signaling in Helicobacter pylori infection;KEGG PATHWAY;hsa05120 |
Pathway | Thromboxane A2 receptor signaling;PID Curated;200069 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | phospholipids as signalling intermediaries;PID BioCarta;100183 |
Pathway | c-src mediated regulation of Cx43 function and closure of gap junctions;PID Reactome;500026 |
Pathway | Gab1 signalosome;PID Reactome;500514 |
Pathway | Integrin alphaIIbbeta3 signaling;PID Reactome;500005 |
Pathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis;PID BioCarta;100255 |
Pathway | amb2 Integrin signaling;PID Curated;200108 |
Pathway | agrin in postsynaptic differentiation;PID BioCarta;100252 |
Pathway | Cell junction organization;Reactome;REACT:20676 |
Pathway | Ephrin B reverse signaling;PID Curated;200173 |
Pathway | Alpha-synuclein signaling;PID Curated;200187 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | E-cadherin signaling in keratinocytes;PID Curated;200125 |
Pathway | Integrin cell surface interactions;Reactome;REACT:13552 |
Pathway | Class I PI3K signaling events;PID Curated;200098 |
Pathway | Trk receptor signaling mediated by PI3K and PLC-gamma;PID Curated;200183 |
Pathway | Nongenotropic Androgen signaling;PID Curated;200145 |
Pathway | Nectin adhesion pathway;PID Curated;200053 |
Pathway | Signaling by EGFR;PID Reactome;500510 |
Pathway | Netrin mediated repulsion signals;PID Reactome;500090 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | CDC42 signaling events;PID Curated;200057 |
Pathway | Regulation of Androgen receptor activity;PID Curated;200102 |
Pathway | gamma-aminobutyric acid receptor life cycle pathway;PID BioCarta;100158 |
Pathway | angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling;PID BioCarta;100236 |
Pathway | Integrin signalling pathway;PANTHER;P00034 |
Pathway | NCAM signaling for neurite out-growth;PID Reactome;500079 |
Pathway | Hemostasis;Reactome;REACT:604 |
Pathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia;PID BioCarta;100184 |
Pathway | FAS (CD95) signaling pathway;PID Curated;200067 |
Pathway | Down-stream signal transduction;PID Reactome;500509 |
Pathway | Internalization of ErbB1;PID Curated;200146 |
Pathway | vegf hypoxia and angiogenesis;PID BioCarta;100006 |
Pathway | Endocytosis;KEGG PATHWAY;hsa04144 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | Signaling events regulated by Ret tyrosine kinase;PID Curated;200058 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met);PID Curated;200032 |
Pathway | LPA receptor mediated events;PID Curated;200011 |
Pathway | calcium signaling by hbx of hepatitis b virus;PID BioCarta;100150 |
Pathway | Focal adhesion;KEGG PATHWAY;hsa04510 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | SHC-mediated cascade;PID Reactome;500250 |
Pathway | Signaling events mediated by focal adhesion kinase;PID Curated;200192 |
Pathway | Syndecan-2-mediated signaling events;PID Curated;200164 |
Pathway | Atypical NF-kappaB pathway;PID Curated;200017 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | Signaling events mediated by VEGFR1 and VEGFR2;PID Curated;200161 |
Pathway | Parkinson disease;PANTHER;P00049 |
Pathway | VEGF signaling pathway;KEGG PATHWAY;hsa04370 |
Pathway | ErbB signaling pathway;KEGG PATHWAY;hsa04012 |
Pathway | Plasma membrane estrogen receptor signaling;PID Curated;200029 |
Pathway | links between pyk2 and map kinases;PID BioCarta;100057 |
Pathway | GnRH signaling pathway;KEGG PATHWAY;hsa04912 |
Pathway | Gap junction;KEGG PATHWAY;hsa04540 |
Pathway | Integrins in angiogenesis;PID Curated;200109 |
Pathway | integrin signaling pathway;PID BioCarta;100123 |
Pathway | Arf6 signaling events;PID Curated;200060 |
Pathway | Tight junction;KEGG PATHWAY;hsa04530 |
Pathway | Signaling by FGFR;Reactome;REACT:9470 |
Pathway | FGF signaling pathway;PID Curated;200189 |
Pathway | Netrin-mediated signaling;PID Curated;200074 |
Disease | Colon cancer, advanced;OMIM |
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External Links |
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Links to Entrez Gene | 6714 |
Links to all GeneRIF Items | 6714 |
Links to iHOP | 6714 |
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Sequence Information |
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Nucleotide Sequence |
>6714 : length: 1611 atgggtagcaacaagagcaagcccaaggatgccagccagcggcgccgcagcctggagccc gccgagaacgtgcacggcgctggcgggggcgctttccccgcctcgcagacccccagcaag ccagcctcggccgacggccaccgcggccccagcgcggccttcgcccccgcggccgccgag cccaagctgttcggaggcttcaactcctcggacaccgtcacctccccgcagagggcgggc ccgctggccggtggagtgaccacctttgtggccctctatgactatgagtctaggacggag acagacctgtccttcaagaaaggcgagcggctccagattgtcaacaacacagagggagac tggtggctggcccactcgctcagcacaggacagacaggctacatccccagcaactacgtg gcgccctccgactccatccaggctgaggagtggtattttggcaagatcaccagacgggag tcagagcggttactgctcaatgcagagaacccgagagggaccttcctcgtgcgagaaagt gagaccacgaaaggtgcctactgcctctcagtgtctgacttcgacaacgccaagggcctc aacgtgaagcactacaagatccgcaagctggacagcggcggcttctacatcacctcccgc acccagttcaacagcctgcagcagctggtggcctactactccaaacacgccgatggcctg tgccaccgcctcaccaccgtgtgccccacgtccaagccgcagactcagggcctggccaag gatgcctgggagatccctcgggagtcgctgcggctggaggtcaagctgggccagggctgc tttggcgaggtgtggatggggacctggaacggtaccaccagggtggccatcaaaaccctg aagcctggcacgatgtctccagaggccttcctgcaggaggcccaggtcatgaagaagctg aggcatgagaagctggtgcagttgtatgctgtggtttcagaggagcccatttacatcgtc acggagtacatgagcaaggggagtttgctggactttctcaagggggagacaggcaagtac ctgcggctgcctcagctggtggacatggctgctcagatcgcctcaggcatggcgtacgtg gagcggatgaactacgtccaccgggaccttcgtgcagccaacatcctggtgggagagaac ctggtgtgcaaagtggccgactttgggctggctcggctcattgaagacaatgagtacacg gcgcggcaaggtgccaaattccccatcaagtggacggctccagaagctgccctctatggc cgcttcaccatcaagtcggacgtgtggtccttcgggatcctgctgactgagctcaccaca aagggacgggtgccctaccctgggatggtgaaccgcgaggtgctggaccaggtggagcgg ggctaccggatgccctgcccgccggagtgtcccgagtccctgcacgacctcatgtgccag tgctggcggaaggagcctgaggagcggcccaccttcgagtacctgcaggccttcctggag gactacttcacgtccaccgagccccagtaccagcccggggagaacctctag |
Protein Sequence |
>6714 : length: 536 MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL |