| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6714 |
Name | SRC |
Synonymous | ASV|SRC1|c-SRC|p60-Src;v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian);SRC;v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
Definition | proto-oncogene c-Src|proto-oncogene tyrosine-protein kinase Src|protooncogene SRC, Rous sarcoma|tyrosine kinase pp60c-src|tyrosine-protein kinase SRC-1 |
Position | 20q12-q13 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
There is no record for SRC | |||
Transcription Factors [Top] |
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Regulation From TransFac database |
estradiol:ER-alpha(h) + Src(h) <==> estradiol:ER-alpha(h):Src(h) (binding) | estradiol:ER-beta-isoform1(h) + AR(h) + Src(h) <==> estradiol:ER-beta-isoform1(h):AR(h):Src(h) (binding) | estradiol:ER-alpha(h) + AR(h) + Src(h) <==> estradiol:ER-alpha(h):AR(h):Src(h) (binding) | Src(h) + STAT3(m) <==> Src(h):STAT3(m) (binding) | Src(h) + Sam68(m) <==> Src(h):Sam68(m) (binding) | arrestin1(m) + Src(h) <==> arrestin1(m):Src(h) (binding) | beta-arrestin1(v.s.) + Src(h) <==> beta-arrestin1(v.s.):Src(h) (binding) | beta-arrestin2(v.s.) + Src(h) <==> beta-arrestin2(v.s.):Src(h) (binding) | FAK1(m){pY397} + Src(h) <==> FAK1(m){pY397}:Src(h) (binding) | beta3-integrin(v.s.) + Src(h) <==> beta3-integrin(v.s.):Src(h) (binding) | alpha IIb-integrin(h):beta3-integrin(h) + Src(h) <==> alpha IIb-integrin(h):beta3-integrin(h):Src(h) (binding) | Src(h) + STAT1(h) <==> Src(h):STAT1(h) (binding) | ErbB1(h) + Src(h) <==> ErbB1(h):Src(h) (binding) | Src(h) + Pyk2-isoform1(h) <==> Src(h):Pyk2-isoform1(h) (binding) | Src(h) + ATP --Csk(h)--> Src(h){pY530} + ADP (phosphorylation) | Src(h) + ATP --> Src(h){pY419} + ADP (phosphorylation; automodification) | PLCgamma1(h) + Src(h) + G-gamma(h):G-beta(h) <==> PLCgamma1(h):Src(h):G-gamma(h):G-beta(h) (binding) | PLCgamma1(m.s.) + Src(h) + G-gamma(h):G-beta(h) <==> PLCgamma1(m.s.):Src(h):G-gamma(h):G-beta(h) (binding) | Src(h) + VDR(h) <==> Src(h):VDR(h) (binding) | crk(h) + Src(h) + Cas(h) + EGFR(h) + CD51(h):beta3-integrin(h) <==> crk(h):Src(h):Cas(h):EGFR(h):CD51(h):beta3-integrin(h) (binding) | Src(h) + CD51(h):beta3-integrin(h) + Cas(h) + EGFR(h){pY} <==> Src(h):CD51(h):beta3-integrin(h):Cas(h):EGFR(h){pY} (binding) | Cas(h) + EGFR(h) + CD51(h) + beta3-integrin(h) + Src(h) <==> Cas(h):EGFR(h):CD51(h):beta3-integrin(h):Src(h) (binding) | Src(h) + mDia2(h) <==> Src(h):mDia2(h) (binding) | Src(h) + mDia1(h) <==> Src(h):mDia1(h) (binding) | pde6g(m) + Src(h) <==> pde6g(m):Src(h) (binding) | Src(h) + DGK-alpha(h) <==> Src(h):DGK-alpha(h) (binding) | Src(h) + IKK-alpha(h) <==> Src(h):IKK-alpha(h) (binding) | Src(h) + IKK-beta(h) <==> Src(h):IKK-beta(h) (binding) | Src(h) + CIN85(m.s.) <==> Src(h):CIN85(m.s.) (binding) | Src(h) + CIN85(h) <==> Src(h):CIN85(h) (binding) | Src(h) + betaARK-1(m.s.) <==> Src(h):betaARK-1(m.s.) (binding) | CIN85(m.s.) + Src(h) + TNFR1(h) <==> CIN85(m.s.):Src(h):TNFR1(h) (binding) | Src(h) + ATP --> Src(h){pY} + ADP (phosphorylation; automodification) | Src(h) --> mGluR1(m.s.) (binding) | Src(h) --> SHP-2(m.s.) (binding) | Src(h) --> ERK2(h){pT185}{pY187} (increase of phosphorylation) | Src(h) --> ERK1(h){pT202} (increase of phosphorylation) | Src(h) --> AR(h) (binding) | Src(h) --> ER-beta(h) (binding) | Src(h) --> ER-alpha(h) (binding) | Src(h) + ATP --> Src(h){pY419} + ADP (phosphorylation) | Src(h) + ATP --> Src(h){p} + ADP (phosphorylation) | Src(h) --> STAT3(h){pS727} (increase of phosphorylation) | Src(h) + MNAR-isoform2(h) <==> Src(h):MNAR-isoform2(h) (binding) | AR(h) + Src(h) + MNAR-isoform2(h) <==> AR(h):Src(h):MNAR-isoform2(h) (binding) | Src(h) + paxillin(h) <==> Src(h):paxillin(h) (binding) | HCV-NS5A-1B(HCV1B) + Src(h) <==> HCV-NS5A-1B(HCV1B):Src(h) (binding) | ErbB2(h){pY1139}{pY1222} + Src(h) <==> ErbB2(h){pY1139}{pY1222}:Src(h) (binding) | Src(h) + ErbB3-isoform1(h){pY1276}{pY1289} <==> Src(h):ErbB3-isoform1(h){pY1276}{pY1289} (binding) | Src(h) + PKCalpha(h) <==> Src(h):PKCalpha(h) (binding) | Src(h) --> Src(h) (translocation) | ErbB1-p170(h){p} + Src(h) <==> ErbB1-p170(h){p}:Src(h) (binding) | ErbB2(h){p} + Src(h) <==> ErbB2(h){p}:Src(h) (binding) | ErbB1(h){pY} + Src(h) <==> ErbB1(h){pY}:Src(h) (binding) | ErbB1-p170(h){pY1016}{pY1092}{pY1110}{pY1125}{pY1172}{pY1197} + Src(h) <==> Src(h):ErbB1-p170(h){pY1016}{pY1092}{pY1110}{pY1125}{pY1172}{pY1197} (binding) | ErbB2(h){pY} + Src(h) <==> Src(h):ErbB2(h){pY} (binding) | Src(h) + CIP4(h) <==> Src(h):CIP4(h) (binding) | Src(h) + STAT5A(h) <==> Src(h):STAT5A(h) (binding) | Src(h) + STAT5B(h) <==> Src(h):STAT5B(h) (binding) | Src(h) + STAT3(h) <==> Src(h):STAT3(h) (binding) | Src(h) + 3 ATP --> Src(h){pY216}{pY419}{pY530} + 3 ADP (phosphorylation) | Src(h) + 2 ATP --> Src(h){pY419}{pY530} + 2 ADP (phosphorylation) | c-Cbl(h) + Src(h) <==> c-Cbl(h):Src(h) (binding) | Pyk2(h) + Src(h) <==> Pyk2(h):Src(h) (binding) | Src(h) + PSD-95alpha(r) <==> Src(h):PSD-95alpha(r) (binding) | Src(h) + NR2A(m) <==> Src(h):NR2A(m) (binding) | trkC(h) + Src(h) <==> trkC(h):Src(h) (binding) | Src(h) + trkC(m.s.) <==> Src(h):trkC(m.s.) (binding) | Src(h) + hnRNPK(h) <==> Src(h):hnRNPK(h) (binding) | trip6(m.s.) + Src(h) <==> trip6(m.s.):Src(h) (binding) | Src(h) + ATP --> Src(h){pY} + ADP (phosphorylation) | Src(h) + EGFR(h){pY} <==> Src(h):EGFR(h){pY} (binding) | Src(h) + PDGFR(h){pY} <==> Src(h):PDGFR(h){pY} (binding) | Src(h) + EGFR(h) <==> Src(h):EGFR(h) (binding) | Src(h) + Cas(m.s.) <==> Src(h):Cas(m.s.) (binding) | Src(h) + IGF-1R(h) <==> Src(h):IGF-1R(h) (binding) | IKK(h) + Src(h) <==> IKK(h):Src(h) (binding) | Src(h) + ATP --> Src(h){pY416} + ADP (phosphorylation) | Src(h) + Sam68(h) <==> Src(h):Sam68(h) (binding) | Src(h) --> AKT-1(h){pS473} (increase of phosphorylation) | STAT1(h){pY701} + Src(h) <==> STAT1(h){pY701}:Src(h) (binding) | Src(h) + 2 ATP --> Src(h){pY}2 + 2 ADP (phosphorylation) | SRC(h) --> Src(h) (expression). | Src(h){pY527} --ptpn21(r)--> Src(h) + p (dephosphorylation) | Src(h){pY419}{pY530} --PTP1B(h)--> Src(h) + 2 p (dephosphorylation) | Src(h){pY530} --PTP1B(h)--> Src(h) + p (dephosphorylation) | PSCDBP(m.s.) --> Src(h) (binding) | Syk(h) --> Src(h) (binding) | Fyn(m.s.) --> Src(h) (binding) | GP6(h) --> Src(h) (activation) | Grp(m.s.) --> Src(h) (activation) | Src(h){pY} --SHP-2(h)--> p + Src(h) (dephosphorylation) | Src(h) --> Src(h) (translocation) | dynamin1(r) + NTP --Src(h)--> dynamin1(r){pY} + NDP (phosphorylation) | beta-catenin(m) + ATP --Src(h)--> beta-catenin(m){pY654} + ADP (phosphorylation) | Sam68(m) + ATP --Src(h)--> Sam68(m){p} + ADP (phosphorylation) | STAT3(m) + ATP --Src(h)--> STAT3(m){pY705} + ADP (phosphorylation) | WOX1(h) + ATP --Src(h)--> WOX1(h){pY33} + ADP (phosphorylation) | GRP3(h) + ATP --Src(h)--> GRP3(h){pY} + ADP (phosphorylation) | EpoR(m) + ATP --Src(h)--> EpoR(m){pY} + ADP (phosphorylation) | EGFR(h) + ATP --Src(h)--> EGFR(h){pY} + ADP (phosphorylation) | IKK-beta(h) + 2 ATP --Src(h)--> IKK-beta(h){pY188}{pY189} + 2 ADP (phosphorylation) | betaARK-1(b) + ATP --Src(h)--> betaARK-1(b){pY} + ADP (phosphorylation) | Prap(h) + ATP --Src(h)--> Prap(h){pY} + ADP (phosphorylation) | ErbB1-p170(h) + ATP --Src(h)--> ErbB1-p170(h){pY869} + ADP (phosphorylation) | ErbB1-p170(h) + 7 ATP --Src(h)--> ErbB1-p170(h){pY915}{pY944}{pY1016}{pY1092}{pY1110}{pY1172}{pY1197} + 7 ADP (phosphorylation) | ErbB2(h) + ATP --Src(h)--> ErbB2(h){p} + ADP (phosphorylation) | p73alpha(h) + ATP --Src(h)--> p73alpha(h){pY28} + ADP (phosphorylation) | PLSCR1(h) + ATP --Src(h)--> PLSCR1(h){pY} + ADP (phosphorylation) | NR2A(r) + ATP --Src(h)--> NR2A(r){pY} + ADP (phosphorylation) | NR2B(r) + ATP --Src(h)--> NR2B(r){pY1472} + ADP (phosphorylation) | caveolin-1(m.s.) + ATP --Src(h)--> caveolin-1(m.s.){pY14} + ADP (phosphorylation) | Enolase(c) + ATP --Src(h)--> Enolase(c){p} + ADP (phosphorylation) | PDE4D4(r) + Src-isoform1(h) <==> PDE4D4(r):Src-isoform1(h) (binding) | PDE4D4(h) + Src-isoform1(h) <==> PDE4D4(h):Src-isoform1(h) (binding) | Shc-1-p66(m.s.) + Src-isoform1(h) <==> Shc-1-p66(m.s.):Src-isoform1(h) (binding) | Src-isoform1(h) + Shc-1-p52(m.s.) <==> Src-isoform1(h):Shc-1-p52(m.s.) (binding) | SRC(h) --> Src-isoform1(h) (expression). | SRC(h) --> Src-isoform2(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
2 | N-myristoyl glycine (By similarity). | Swiss-Prot 53.0 | 17 | Phosphoserine. | Swiss-Prot 53.0 | 69 | Phosphoserine. | Swiss-Prot 53.0 | 75 | Phosphoserine. | Swiss-Prot 53.0 | 419 | Phosphotyrosine (by autocatalysis). | Swiss-Prot 53.0 | 530 | Phosphotyrosine (by CSK). | Swiss-Prot 53.0 | 529 | Phosphotyrosine (Csk) | 3103926;12468645;12387813 | Phospho.ELM 6.0 | 215 | Phosphotyrosine (Src) | 12753909 | Phospho.ELM 6.0 | 418 | Phosphotyrosine (Src;PDGFR al) | 6273838;11278940;7578094;11804588;15489898;1708198 | Phospho.ELM 6.0 | 96 | Phosphoserine | 1713455 | Phospho.ELM 6.0 | 11 | Phosphoserine | 2136766 | Phospho.ELM 6.0 | 337 | Phosphotyrosine (Src) | 7578094 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr20 |
Promoter: 35406471 - 35408471 | Agilent_014791 |
chr20 |
Promoter: 35405002 - 35407002 | GoldenGate_Methylation_Cancer_Panel_I |
chr20 |
Promoter: 35406471 - 35408471 | GoldenGate_Methylation_Cancer_Panel_I |
chr20 |
Promoter: 35406471 - 35408471 | GSE27584 |
chr20 |
Promoter: 35406471 - 35408471 | Agilent_014791_44K |