General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information |
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Gene ID | 6772 |
Name | STAT1 |
Synonym | CANDF7|ISGF-3|STAT91;signal transducer and activator of transcription 1, 91kDa;STAT1;signal transducer and activator of transcription 1, 91kDa |
Definition | signal transducer and activator of transcription 1-alpha/beta|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84 |
Position | 2q32.2 |
Gene Type | protein-coding |
PAH Type |
Description |
PAH | "Pulmonary arterial hypertension (PAH) may be idiopathic, familial or associated with various disease processes. The vascular lesions common to all are the plexiform lesions. It is well documented that the plexiform lesions are angioproliferative, but what leads to this angioproliferation is not so clear. Here, we consider the association of viruses, including HIV, human herpesvirus-8, hepatitis B and hepatitis C, with angioproliferation and the development of PAH. The pathogenesis of viral infections often involves proangiogenic and prosurvival signals, similar to the signals found in the phenotypically abnormal endothelial cells of PAH. However, viral infections alone are unlikely to lead to PAH because - much like the viral induction of cancers - additional cofactors, including genetic predisposition, are undoubtedly required for the development of disease. In this article, we also discuss how a dysregulated immune system, in conjunction with a viral infection, could cause PAH. Both autoimmune diseases and viruses are associated with defects in the immune regulatory system, primarily in the T-cell system. These T-cell defects may be a common pathway for the formation of plexiform lesions. Regardless of the route by which viruses may lead to PAH, it is important to recognize their role in this rare disease. Studies of viral pathways in angioproliferation - both in vitro and in animal models - may lead to novel therapeutic targets in PAH." |
More detail of all Human literatures about STAT1 | |
Pathways and Diseases |
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Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | ifn gamma signaling pathway;PID BioCarta;100138 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | IL23-mediated signaling events;PID Curated;200131 |
Pathway | Interferon-gamma signaling pathway;PANTHER;P00035 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | IL12-mediated signaling events;PID Curated;200034 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | Glucocorticoid receptor regulatory network;PID Curated;200077 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | TNF receptor signaling pathway;PID Curated;200086 |
Pathway | mapkinase signaling pathway;PID BioCarta;100113 |
Pathway | EPO signaling pathway;PID Curated;200157 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | ifn alpha signaling pathway;PID BioCarta;100139 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | inhibition of cellular proliferation by gleevec;PID BioCarta;100154 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | p38 mapk signaling pathway;PID BioCarta;100085 |
Pathway | JAK/STAT signaling pathway;PANTHER;P00038 |
Pathway | Leishmaniasis;KEGG PATHWAY;hsa05140 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | Toll-like receptor signaling pathway;KEGG PATHWAY;hsa04620 |
Pathway | tpo signaling pathway;PID BioCarta;100012 |
Pathway | il22 soluble receptor signaling pathway;PID BioCarta;100131 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | Oxidative stress response;PANTHER;P00046 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | p53 pathway feedback loops 2;PANTHER;P04398 |
Pathway | IL27-mediated signaling events;PID Curated;200023 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Pathway | FGF signaling pathway;PID Curated;200189 |
Disease | Mycobacterial infection, atypical, familial disseminated;OMIM |
Disease | STAT1 deficiency, complete;OMIM |
Disease | Primary immunodeficiency;KEGG DISEASE |
Disease | Immune system diseases;KEGG DISEASE |
Disease | IFN-gamma/IL-12 axis;KEGG DISEASE;H00089 |
External Links |
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Links to Entrez Gene | 6772 |
Links to all GeneRIF Items | 6772 |
Links to iHOP | 6772 |
Sequence Information |
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Nucleotide Sequence |
>6772 : length: 2253 atgtctcagtggtacgaacttcagcagcttgactcaaaattcctggagcaggttcaccag ctttatgatgacagttttcccatggaaatcagacagtacctggcacagtggttagaaaag caagactgggagcacgctgccaatgatgtttcatttgccaccatccgttttcatgacctc ctgtcacagctggatgatcaatatagtcgcttttctttggagaataacttcttgctacag cataacataaggaaaagcaagcgtaatcttcaggataattttcaggaagacccaatccag atgtctatgatcatttacagctgtctgaaggaagaaaggaaaattctggaaaacgcccag agatttaatcaggctcagtcggggaatattcagagcacagtgatgttagacaaacagaaa gagcttgacagtaaagtcagaaatgtgaaggacaaggttatgtgtatagagcatgaaatc aagagcctggaagatttacaagatgaatatgacttcaaatgcaaaaccttgcagaacaga gaacacgagaccaatggtgtggcaaagagtgatcagaaacaagaacagctgttactcaag aagatgtatttaatgcttgacaataagagaaaggaagtagttcacaaaataatagagttg ctgaatgtcactgaacttacccagaatgccctgattaatgatgaactagtggagtggaag cggagacagcagagcgcctgtattggggggccgcccaatgcttgcttggatcagctgcag aactggttcactatagttgcggagagtctgcagcaagttcggcagcagcttaaaaagttg gaggaattggaacagaaatacacctacgaacatgaccctatcacaaaaaacaaacaagtg ttatgggaccgcaccttcagtcttttccagcagctcattcagagctcgtttgtggtggaa agacagccctgcatgccaacgcaccctcagaggccgctggtcttgaagacaggggtccag ttcactgtgaagttgagactgttggtgaaattgcaagagctgaattataatttgaaagtc aaagtcttatttgataaagatgtgaatgagagaaatacagtaaaaggatttaggaagttc aacattttgggcacgcacacaaaagtgatgaacatggaggagtccaccaatggcagtctg gcggctgaatttcggcacctgcaattgaaagaacagaaaaatgctggcaccagaacgaat gagggtcctctcatcgttactgaagagcttcactcccttagttttgaaacccaattgtgc cagcctggtttggtaattgacctcgagacgacctctctgcccgttgtggtgatctccaac gtcagccagctcccgagcggttgggcctccatcctttggtacaacatgctggtggcggaa cccaggaatctgtccttcttcctgactccaccatgtgcacgatgggctcagctttcagaa gtgctgagttggcagttttcttctgtcaccaaaagaggtctcaatgtggaccagctgaac atgttgggagagaagcttcttggtcctaacgccagccccgatggtctcattccgtggacg aggttttgtaaggaaaatataaatgataaaaattttcccttctggctttggattgaaagc atcctagaactcattaaaaaacacctgctccctctctggaatgatgggtgcatcatgggc ttcatcagcaaggagcgagagcgtgccctgttgaaggaccagcagccggggaccttcctg ctgcggttcagtgagagctcccgggaaggggccatcacattcacatgggtggagcggtcc cagaacggaggcgaacctgacttccatgcggttgaaccctacacgaagaaagaactttct gctgttactttccctgacatcattcgcaattacaaagtcatggctgctgagaatattcct gagaatcccctgaagtatctgtatccaaatattgacaaagaccatgcctttggaaagtat tactccaggccaaaggaagcaccagagccaatggaacttgatggccctaaaggaactgga tatatcaagactgagttgatttctgtgtctgaagttcacccttctagacttcagaccaca gacaacctgctccccatgtctcctgaggagtttgacgaggtgtctcggatagtgggctct gtagaattcgacagtatgatgaacacagtatag |
Protein Sequence |
>6772 : length: 750 MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV |