| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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Gene ID | 6772 |
Name | STAT1 |
Synonymous | CANDF7|ISGF-3|STAT91;signal transducer and activator of transcription 1, 91kDa;STAT1;signal transducer and activator of transcription 1, 91kDa |
Definition | signal transducer and activator of transcription 1-alpha/beta|signal transducer and activator of transcription-1|transcription factor ISGF-3 components p91/p84 |
Position | 2q32.2 |
Gene Type | protein-coding |
Gene Regulation: | ENCODE RegulomeDB Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
ENCODE RegulomeDB [Top] | |||
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Link to UCSC genome |
Matched SNP location |
dbSNP ID |
Regulatory information |
chr2:191829084-191885686 | chr2:191838204-191838204 | rs6718902 | Single_Nucleotides|eQTL|GLS, Motifs|PWM|Nkx2-3, Chromatin_Structure|DNase-seq|Hmveclly, Chromatin_Structure|DNase-seq|Hmvecdneo, Chromatin_Structure|FAIRE|Gm12891, Protein_Binding|ChIP-seq|POLR2A | chr2:191829084-191885686 | chr2:191838514-191838514 | rs13395505 | Single_Nucleotides|eQTL|GLS, Chromatin_Structure|DNase-seq|Hmvecdlyneo, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A | chr2:191829084-191885686 | chr2:191839976-191839976 | rs1914408 | Single_Nucleotides|eQTL|GLS, Motifs|PWM|HES1, Chromatin_Structure|DNase-seq|Be2c, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A | chr2:191829084-191885686 | chr2:191855521-191855521 | rs7562024 | Single_Nucleotides|eQTL|GLS, Protein_Binding|ChIP-seq|POLR2A | chr2:191829084-191885686 | chr2:191860529-191860529 | rs10167514 | Single_Nucleotides|eQTL|GLS, Protein_Binding|ChIP-seq|POLR2A, Protein_Binding|ChIP-seq|POLR2A |
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Transcription Factors [Top] |
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Regulation From TransFac database |
STAT1beta(h) --> IRF1(h) (DNA binding). | STAT1alpha(h) + STAT1beta(h) <==> STAT1alpha(h):STAT1beta(h) (binding). | STAT1beta(h) + STAT2(h) <==> STAT1beta(h):STAT2(h) (binding) | STAT1alpha(m) + STAT1beta(h) <==> STAT1beta(h):STAT1alpha(m) (binding). | STAT1beta(h) --> CCL2(h) (DNA binding; transactivation). | STAT1beta(h) --> protein remnants (degradation) | brca1(h) + STAT1beta(h) <==> brca1(h):STAT1beta(h) (binding) | STAT1beta(h) + RON(h) <==> STAT1beta(h):RON(h) (binding) | ErbB1(h) + STAT1beta(h) <==> ErbB1(h):STAT1beta(h) (binding) | STAT1beta(h) + ATP --> STAT1beta(h){pY} + ADP (phosphorylation) | STAT1beta(h) + CaMKII-gamma(h) <==> STAT1beta(h):CaMKII-gamma(h) (binding) | STAT1beta(h) --> Cxcl9(m) (DNA binding). | STAT1beta(h) + ATP --> STAT1beta(h){pY701} + ADP (phosphorylation) | STAT1(h) --> STAT1beta(h) (expression). | IFNgamma(m.s.) --> STAT1beta(h) (increase of abundance) | IFNbeta(h) --> STAT1beta(h) (increase of abundance) | PDGFRbeta(h) + STAT1alpha(h) <==> PDGFRbeta(h):STAT1alpha(h) (binding) | STAT1alpha(h) --> IRF1(h) (DNA binding; transactivation). | c-Kit(h) + STAT1alpha(h) <==> c-Kit(h):STAT1alpha(h) (binding) | STAT1alpha(h) + ATP --c-Kit(h)--> STAT1alpha(h){pY} + ADP (phosphorylation) | STAT1alpha(m) + STAT1alpha(h) <==> STAT1alpha(m):STAT1alpha(h) (binding). | STAT1alpha(h) + STAT2(h) <==> STAT1alpha(h):STAT2(h) (binding) | STAT1alpha(h) + STAT1beta(h) <==> STAT1alpha(h):STAT1beta(h) (binding). | STAT1alpha(h) + ATP --> STAT1alpha(h){pS727} + ADP (phosphorylation) | STAT1alpha(h) + STAT1alpha(h) <==> STAT1alpha(h):STAT1alpha(h) (binding). | STAT1alpha(h) --> CYBB(h) (DNA binding; transactivation). | STAT1alpha(h) + NTP --Bmx(m)--> STAT1alpha(h){pY} + NDP (phosphorylation) | STAT1alpha(h) + NTP --Jak2(m)--> STAT1alpha(h){pY} + NDP (phosphorylation) | STAT1alpha(h) --> CCL2(h) (DNA binding; transactivation). | STAT1alpha(h) --> Irf1(r) (DNA binding; transactivation). | STAT1alpha(h) + ATP --> STAT1alpha(h){pY} + ADP (phosphorylation) | STAT1alpha(h) --> protein remnants (degradation) | brca1(h) + STAT1alpha(h) <==> brca1(h):STAT1alpha(h) (binding) | STAT1alpha(h) + brca1(h) <==> STAT1alpha(h):brca1(h) (binding) | STAT1alpha(h) + RON(h) <==> STAT1alpha(h):RON(h) (binding) | ErbB1(h) + STAT1alpha(h) <==> ErbB1(h):STAT1alpha(h) (binding) | STAT1alpha(h) --> CD40(h) (DNA binding). | STAT1alpha(h) --> CD86(h) (DNA binding). | STAT1alpha(h) --> S100A10(h) (DNA binding). | STAT1alpha(h) --> HLA-E(h) (DNA binding). | STAT1alpha(h) --> FCGR1C(h) (DNA binding). | STAT1alpha(h) --> Tap1(h) (DNA binding). | PIAS1(m.s.) + STAT1alpha(h) <==> PIAS1(m.s.):STAT1alpha(h) (binding) | STAT1alpha(h) + 2 ATP --> STAT1alpha(h){pY701}{pS727} + 2 ADP (phosphorylation) | p300(h) + STAT1alpha(h) <==> p300(h):STAT1alpha(h) (binding) | STAT1alpha(h) + ATP --> STAT1alpha(h){pY701} + ADP (phosphorylation) | STAT1alpha(h) + CaMKII(h) <==> STAT1alpha(h):CaMKII(h) (binding) | STAT1alpha(h) + CaMKII-gamma(h) <==> STAT1alpha(h):CaMKII-gamma(h) (binding) | STAT1alpha(h) + ATP --CaMKII(h)--> STAT1alpha(h){pS727} + ADP (phosphorylation) | STAT1alpha(h) --> Cxcl9(m) (DNA binding). | STAT1alpha(h) --> PRF1(h) (DNA binding). | STAT1alpha(h) + IFNGR(h){pY457} <==> STAT1alpha(h):IFNGR(h){pY457} (binding) | STAT1alpha(h) --> STAT1alpha(h) (translocation) | STAT1alpha(h) --> STAT1alpha(h) (translocation) | ERK2(h) + STAT1alpha(h) <==> ERK2(h):STAT1alpha(h) (binding) | STAT1(h) --> STAT1alpha(h) (expression). | IFNgamma(m.s.) --> STAT1alpha(h) (increase of abundance) | IFNbeta(h) --> STAT1alpha(h) (increase of abundance) | STAT1alpha(h) --> STAT1alpha(h) (translocation) | STAT1alpha(h) --> STAT1alpha(h) (translocation) | IFNbeta(h) --> STAT1alpha(h) (increase of abundance) | STAT1(h) --> IL-2Ralpha(m) (DNA binding). | STAT1(h) --> IL-2Ralpha(h) (DNA binding). | STAT1(h) --> A2-Mag(r) (DNA binding). | STAT1(h) --> FOS(h) (DNA binding; transactivation). | STAT1(h) --> FCGR1A(h) (DNA binding). | STAT1(h) --> CDKN1A(h) (DNA binding; transactivation). | STAT1(h) --Caspase-3(h)--> protein remnants (processing) | STAT1(h) + ATP --p38alpha(h)--> STAT1(h){pS727} + ADP (phosphorylation) | STAT1(h) + ATP --p38beta2(h)--> STAT1(h){pS727} + ADP (phosphorylation) | STAT1(h) + ATP --protein tyrosine kinases(v.s.)--> STAT1(h){pY701} + ADP (phosphorylation) | STAT1(h) + ATP --Jak2(r)--> STAT1(h){pY} + ADP (phosphorylation) | RACK1(h) + STAT1(h) <==> RACK1(h):STAT1(h) (binding) | STAT1(h) --> CIITA(h) (DNA binding; transactivation). | 2 STAT1(h) <==> STAT1(h):STAT1(h) (binding) | STAT1(h) + STAT3(h) <==> STAT1(h):STAT3(h) (binding) | STAT1(h) + ATP --Jak2(m)--> STAT1(h){p} + ADP (phosphorylation) | Fes(h) + STAT1(h) <==> Fes(h):STAT1(h) (binding) | STAT1(h) --> c-myc(h) (DNA binding; transactivation). | RelA-p65(h) + STAT1(h) + CBP(m) <==> STAT1(h):RelA-p65(h):CBP(m) (assembly; binding; interaction) | STAT1(h) --> Cxcl9(m) (DNA binding; transactivation). | ErbB1(h) + STAT1(h) <==> ErbB1(h):STAT1(h) (binding) | Src(h) + STAT1(h) <==> Src(h):STAT1(h) (binding) | STAT1(h) --> CCND1(h) (DNA binding; transactivation). | STAT1(h) --> TRH(h) (DNA binding; transactivation). | STAT1(h) --> IRF1(h) (DNA binding; transactivation). | STAT1(h) --> PIM1(h) (DNA binding; transactivation). | STAT1(h) --> IFP 53(h) (DNA binding; transactivation). | STAT1(h) --> SOAT1(h) (DNA binding; transactivation). | uPAR(h) + STAT1(h) <==> uPAR(h):STAT1(h) (binding) | STAT1(h) + ATP --> STAT1(h){p} + ADP (phosphorylation) | STAT1(h) + c-Jun(h) <==> STAT1(h):c-Jun(h) (binding) [re. | STAT1(h) + sumo1(m.s.) --> STAT1(h){sumo} (sumoylation) | STAT1(h) + sumo1(h) --> STAT1(h){sumo} (sumoylation) | HSF1(h) + STAT1(h) <==> HSF1(h):STAT1(h) (binding) | Chk2(h) + STAT1(h) <==> Chk2(h):STAT1(h) (binding) | NFBD1(h) + STAT1(h) <==> NFBD1(h):STAT1(h) (binding) | 53BP1(h) + STAT1(h) <==> 53BP1(h):STAT1(h) (binding) | STAT1(h) --> ATM(h){pS1981} (increase of abundance) | GRP58(h) + Hsp90(h) + STAT1(h) + caveolin-1(h) + STAT3(h) <==> GRP58(h):Hsp90(h):STAT1(h):caveolin-1(h):STAT3(h) (binding) | STAT1(h) --> STAT1(h) (translocation) | irf1(h) + STAT1(h) <==> irf1(h):STAT1(h) (binding) | STAT1(h) --> Mt1(m) (DNA binding). | STAT1(h) --> OPRM1(h) (DNA binding). | STAT1(h) --> PSMB9(h) (DNA binding). | STAT1(h) + ATP --> STAT1(h){pY701} + ADP (phosphorylation) | ErbB1-p170(h){pY998}{pY1016} + STAT1(h) <==> ErbB1-p170(h){pY998}{pY1016}:STAT1(h) (binding) | ErbB2(h){pY1221}{pY1222} + STAT1(h) <==> ErbB2(h){pY1221}{pY1222}:STAT1(h) (binding) | ErbB3-isoform1(h){pY1262} + STAT1(h) <==> ErbB3-isoform1(h){pY1262}:STAT1(h) (binding) | ErbB4(h) + STAT1(h) <==> ErbB4(h):STAT1(h) (binding) | HCV-core(HCV) + STAT1(h) <==> HCV-core(HCV):STAT1(h) (binding) | STAT2(h) + STAT1(h) <==> STAT2(h):STAT1(h) (binding) | HCV-NS5A-1B-Japanese(HCV1BJapan) + STAT1(h) <==> HCV-NS5A-1B-Japanese(HCV1BJapan):STAT1(h) (binding) | STAT1(h) --> VIP(h) (DNA binding). | STAT1(h) --> GLOB-AG(h) (DNA binding). | STAT1(h) --> NOS2(h) (DNA binding; transactivation). | STAT1(h) --> MUC1(h) (DNA binding; transactivation). | STAT1(h) --> IL6ST(h) (DNA binding; transactivation). | STAT1(h) --> Tcfap2a(m) (DNA binding). | Jak1(h) + STAT1(h) <==> Jak1(h):STAT1(h) (binding) | STAT1(h) + ATP --> STAT1(h){pY} + ADP (phosphorylation) | STAT1(h) + STAT2(h) <==> STAT2(h):STAT1(h) (binding) | STAT1(h) + LPLUNC3(h) <==> STAT1(h):LPLUNC3(h) (binding) | RBTN2(h) + STAT1(h) <==> RBTN2(h):STAT1(h) (binding) | STAT1(h) + eif1ad(h) <==> STAT1(h):eif1ad(h) (binding) | STAT1(h) --> CCL19(h) (DNA binding). | STAT1(h) + STAT5(h) <==> STAT1(h):STAT5(h) (binding) | STAT1(h) --> Ly6a(m) (DNA binding). | STAT1(h) --> ICAM1(h) (DNA binding). | STAT1(h) --> INDO(h) (DNA binding). | STAT1(h) --> IFNG(h) (DNA binding). | STAT1(h) --> CD86(h) (DNA binding). | STAT1(h) --> MYD88(h) (DNA binding). | STAT1(h) --> IL21(h) (DNA binding). | STAT1(h) --> AGT(h) (DNA binding). | STAT1(h) --> FCER2(h) (DNA binding). | STAT1(h) --> Klf4(m) (DNA binding). | STAT1(h) --> NOX1(h) (DNA binding). | STAT1(h) --> MVP(h) (DNA binding). | STAT1(h) --> Tap1(h) (DNA binding). | STAT1(h) --> BIRC4BP(h) (DNA binding). | STAT1(h) --> Irf1(m) (DNA binding). | STAT1(h) --> FCGR1C(h) (DNA binding). | STAT1(h) + 2 ATP --> STAT1(h){pY701}{pS727} + 2 ADP (phosphorylation) | STAT1(h) + ATP --> STAT1(h){pS727} + ADP (phosphorylation) | STAT1(h) --> BACE1(h) (transactivation) | STAT1(h) --> Asp2(h) (increase of abundance) | STAT1(h) + PKCdelta(h) <==> STAT1(h):PKCdelta(h) (binding) | STAT1(h) + Src(h){pY} <==> STAT1(h):Src(h){pY} (binding) | Jak2(h) + STAT1(h) <==> Jak2(h):STAT1(h) (binding) | STAT1(h) + Jak1(h){pY} <==> STAT1(h):Jak1(h){pY} (binding) | STAT1(h) + Jak2(h){pY} <==> STAT1(h):Jak2(h){pY} (binding) | STAT1(h) --> c-myc(m) (DNA binding). | STAT1(h) --> IL1B(h) (DNA binding). | STAT1(h) --> MSR1(h) (DNA binding). | STAT1(h) --> IVL(h) (DNA binding). | STAT1(h) --> FCGRT(h) (DNA binding). | STAT1(h) + ATP --PKCdelta(h)--> STAT1(h){pS727} + ADP (phosphorylation) | STAT1(h) --> S100P(h) (DNA binding). | IL-22(h) --> STAT1(h) (activation; phosphorylation) | IL-17A(h) --> STAT1(h) (activation; phosphorylation) | AT2(h) --> STAT1(h) (activation) | STAT1(h) --> STAT1(h) (expression). | p53(h) --/ STAT1(h) (decrease of abundance) | STAT1(h) --> STAT1(h) (translocation) | HCV-NS4A(HCV):HCV-NS3(HCV) --/ STAT1(h) (decrease of abundance) | HCV-E1(HCV) --/ STAT1(h) (decrease of abundance) | HCV-E2(HCV) --/ STAT1(h) (decrease of abundance) | IFNgamma(m.s.) --> STAT1(h) (increase of abundance) | IFNbeta(h) --> STAT1(h) (increase of abundance) | IFNgamma(h) --> STAT1(h) (increase of abundance) | IFNalpha(m.s.) --> STAT1(h) (increase of abundance) | STAT1(h){pY701} --TC-PTP(h)--> STAT1(h) + p (dephosphorylation) | IFN-lambda(m.s.) --> STAT1(h) (increase of abundance) | IFNalpha(m) --> STAT1(h) (increase of abundance) | IFNbeta(m.s.) --> STAT1(h) (increase of abundance) | IFNalpha2a(h) --> STAT1(h) (increase of abundance) |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
701 | Phosphotyrosine (by JAK). | Swiss-Prot 53.0 | 727 | Phosphoserine. | Swiss-Prot 53.0 | 727 | Phosphoserine | 95354205 | Phospho.ELM 6.0 | 701 | Phosphotyrosine (Src;EGFR;JAK) | 7592750;15322115;11438544;10748192 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
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chr2 |
Promoter: 191586681 - 191588681 | Agilent_014791 |
chr2 |
Promoter: 191586681 - 191588681 | GSE27584 |
chr2 |
Promoter: 191586681 - 191588681 | GSE27584 |
chr2 |
Promoter: 191586681 - 191588681 | Agilent_014791_44K |
chr2 |
Promoter: 191586681 - 191588681 | Agilent_014791 |
chr2 |
Promoter: 191586681 - 191588681 | PMID:16242928 |
chr2 |
Promoter: 191586681 - 191588681 | PMID:16242928 |
chr2 |
Promoter: 191586681 - 191588681 | PMID:16449678 |
chr2 |
Promoter: 191586681 - 191588681 | PMID:16449678 |