| General information | Literature | Expression | Regulation | Variant | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6774 |
Name | STAT3 |
Synonym | APRF|HIES;signal transducer and activator of transcription 3 (acute-phase response factor);STAT3;signal transducer and activator of transcription 3 (acute-phase response factor) |
Definition | DNA-binding protein APRF|acute-phase response factor|signal transducer and activator of transcription 3 |
Position | 17q21.31 |
Gene Type | protein-coding |
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PAH Type |
Description |
PAH | Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway. |
PAH | Signal transducers and activators of transcription-3/pim1 axis plays a critical role in the pathogenesis of human pulmonary arterial hypertension. |
| More detail of all Human literatures about STAT3 | |
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Pathways and Diseases |
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Pathway | Signaling events mediated by TCPTP;PID Curated;200065 |
Pathway | Signaling events mediated by HDAC Class I;PID Curated;200070 |
Pathway | role of erbb2 in signal transduction and oncology;PID BioCarta;100147 |
Pathway | Inflammation mediated by chemokine and cytokine signaling pathway;PANTHER;P00031 |
Pathway | Signaling in Immune system;Reactome;REACT:6900 |
Pathway | ErbB1 downstream signaling;PID Curated;200113 |
Pathway | IL23-mediated signaling events;PID Curated;200131 |
Pathway | CXCR4-mediated signaling events;PID Curated;200083 |
Pathway | pdgf signaling pathway;PID BioCarta;100077 |
Pathway | IL12 signaling mediated by STAT4;PID Curated;200197 |
Pathway | IL12-mediated signaling events;PID Curated;200034 |
Pathway | Toxoplasmosis;KEGG PATHWAY;hsa05145 |
Pathway | Pancreatic cancer;KEGG PATHWAY;hsa05212 |
Pathway | Signaling by PDGF;Reactome;REACT:16888 |
Pathway | IL27-mediated signaling events;PID Curated;200023 |
Pathway | PDGF signaling pathway;PANTHER;P00047 |
Pathway | egf signaling pathway;PID BioCarta;100181 |
Pathway | EGF receptor (ErbB1) signaling pathway;PID Curated;200085 |
Pathway | Neurotrophic factor-mediated Trk receptor signaling;PID Curated;200128 |
Pathway | PDGFR-beta signaling pathway;PID Curated;200127 |
Pathway | EGF receptor signaling pathway;PANTHER;P00018 |
Pathway | IL2-mediated signaling events;PID Curated;200082 |
Pathway | Notch-mediated HES/HEY network;PID Curated;200196 |
Pathway | Ras Pathway;PANTHER;P04393 |
Pathway | Signalling by NGF;Reactome;REACT:11061 |
Pathway | IFN-gamma pathway;PID Curated;200110 |
Pathway | Adipocytokine signaling pathway;KEGG PATHWAY;hsa04920 |
Pathway | ErbB2/ErbB3 signaling events;PID Curated;200119 |
Pathway | bioactive peptide induced signaling pathway;PID BioCarta;100226 |
Pathway | Signaling events mediated by PTP1B;PID Curated;200033 |
Pathway | JAK/STAT signaling pathway;PANTHER;P00038 |
Pathway | Angiogenesis;PANTHER;P00005 |
Pathway | erk1/erk2 mapk signaling pathway;PID BioCarta;100170 |
Pathway | Pathways in cancer;KEGG PATHWAY;hsa05200 |
Pathway | Hepatitis C;KEGG PATHWAY;hsa05160 |
Pathway | Jak-STAT signaling pathway;KEGG PATHWAY;hsa04630 |
Pathway | tpo signaling pathway;PID BioCarta;100012 |
Pathway | il22 soluble receptor signaling pathway;PID BioCarta;100131 |
Pathway | Chemokine signaling pathway;KEGG PATHWAY;hsa04062 |
Pathway | il 6 signaling pathway;PID BioCarta;100126 |
Pathway | IL6-mediated signaling events;PID Curated;200124 |
Pathway | RAC1 signaling pathway;PID Curated;200190 |
Pathway | Interleukin signaling pathway;PANTHER;P00036 |
Pathway | Signaling events mediated by Stem cell factor receptor (c-Kit);PID Curated;200156 |
Pathway | stat3 signaling pathway;PID BioCarta;100028 |
Pathway | GMCSF-mediated signaling events;PID Curated;200015 |
Pathway | Acute myeloid leukemia;KEGG PATHWAY;hsa05221 |
Disease | Cancers;KEGG DISEASE |
Disease | Other well-defined immunodeficiency syndromes;KEGG DISEASE;H00107 |
Disease | Multiple sclerosis;NHGRI |
Disease | multiple sclerosis;GAD |
Disease | IMMUNE;GAD |
Disease | Immune system diseases;KEGG DISEASE |
Disease | Hyper-IgE recurrent infection syndrome;OMIM |
Disease | kidney cancer;GAD |
Disease | PHARMACOGENOMIC;GAD |
Disease | Oral cancer;KEGG DISEASE;H00016 |
Disease | Asthma;GAD |
Disease | Crohn's disease;GAD |
Disease | Head and neck cancers;KEGG DISEASE |
Disease | Crohn's disease;NHGRI |
Disease | Primary immunodeficiency;KEGG DISEASE |
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External Links |
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Links to Entrez Gene | 6774 |
Links to all GeneRIF Items | 6774 |
Links to iHOP | 6774 |
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Sequence Information |
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Nucleotide Sequence |
>6774 : length: 2310 atggcccaatggaatcagctacagcagcttgacacacggtacctggagcagctccatcag ctctacagtgacagcttcccaatggagctgcggcagtttctggccccttggattgagagt caagattgggcatatgcggccagcaaagaatcacatgccactttggtgtttcataatctc ctgggagagattgaccagcagtatagccgcttcctgcaagagtcgaatgttctctatcag cacaatctacgaagaatcaagcagtttcttcagagcaggtatcttgagaagccaatggag attgcccggattgtggcccggtgcctgtgggaagaatcacgccttctacagactgcagcc actgcggcccagcaagggggccaggccaaccaccccacagcagccgtggtgacggagaag cagcagatgctggagcagcaccttcaggatgtccggaagagagtgcaggatctagaacag aaaatgaaagtggtagagaatctccaggatgactttgatttcaactataaaaccctcaag agtcaaggagacatgcaagatctgaatggaaacaaccagtcagtgaccaggcagaagatg cagcagctggaacagatgctcactgcgctggaccagatgcggagaagcatcgtgagtgag ctggcggggcttttgtcagcgatggagtacgtgcagaaaactctcacggacgaggagctg gctgactggaagaggcggcaacagattgcctgcattggaggcccgcccaacatctgccta gatcggctagaaaactggataacgtcattagcagaatctcaacttcagacccgtcaacaa attaagaaactggaggagttgcagcaaaaagtttcctacaaaggggaccccattgtacag caccggccgatgctggaggagagaatcgtggagctgtttagaaacttaatgaaaagtgcc tttgtggtggagcggcagccctgcatgcccatgcatcctgaccggcccctcgtcatcaag accggcgtccagttcactactaaagtcaggttgctggtcaaattccctgagttgaattat cagcttaaaattaaagtgtgcattgacaaagactctggggacgttgcagctctcagagga tcccggaaatttaacattctgggcacaaacacaaaagtgatgaacatggaagaatccaac aacggcagcctctctgcagaattcaaacacttgaccctgagggagcagagatgtgggaat gggggccgagccaattgtgatgcttccctgattgtgactgaggagctgcacctgatcacc tttgagaccgaggtgtatcaccaaggcctcaagattgacctagagacccactccttgcca gttgtggtgatctccaacatctgtcagatgccaaatgcctgggcgtccatcctgtggtac aacatgctgaccaacaatcccaagaatgtaaacttttttaccaagcccccaattggaacc tgggatcaagtggccgaggtcctgagctggcagttctcctccaccaccaagcgaggactg agcatcgagcagctgactacactggcagagaaactcttgggacctggtgtgaattattca gggtgtcagatcacatgggctaaattttgcaaagaaaacatggctggcaagggcttctcc ttctgggtctggctggacaatatcattgaccttgtgaaaaagtacatcctggccctttgg aacgaagggtacatcatgggctttatcagtaaggagcgggagcgggccatcttgagcact aagcctccaggcaccttcctgctaagattcagtgaaagcagcaaagaaggaggcgtcact ttcacttgggtggagaaggacatcagcggtaagacccagatccagtccgtggaaccatac acaaagcagcagctgaacaacatgtcatttgctgaaatcatcatgggctataagatcatg gatgctaccaatatcctggtgtctccactggtctatctctatcctgacattcccaaggag gaggcattcggaaagtattgtcggccagagagccaggagcatcctgaagctgacccaggc gctgccccatacctgaagaccaagtttatctgtgtgacaccaacgacctgcagcaatacc attgacctgccgatgtccccccgcactttagattcattgatgcagtttggaaataatggt gaaggtgctgaaccctcagcaggagggcagtttgagtccctcacctttgacatggagttg acctcggagtgcgctacctcccccatgtga |
Protein Sequence |
>6774 : length: 769 MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGAAPYLKTKFICVTPTTCSNT IDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM |